Background and Objectives: This study aimed to examine the function of various inflammation parameters and their interactions in the pathology of Bipolar disorder (BD) and to assess whether they could be biomarkers in the relationship between criminal behavior and BD. Materials and Methods: Overall, 1029 participants, including 343 patients with BD who have committed offenses, 343 nonoffending patients with BD, and 343 healthy controls, were included in this retrospective study. Neutrophil, lymphocyte, monocyte, and platelet counts; high-density lipoprotein (HDL-c) levels; systemic immune-inflammatory index (SII), systemic inflammatory response index (SIRI), neutrophil to high-density lipoprotein ratio (NHR), lymphocyte to high-density lipoprotein ratio (LHR), monocyte to high-density lipoprotein ratio (MHR), platelet to high-density lipoprotein ratio (PHR) were measured. Results: Significant differences were observed between the groups in terms of SII, SIRI, NHR, LHR, MHR, PHR, neutrophil, and monocyte values (p < 0.001). The lymphocyte counts were significantly higher in the patients with BD who committed offenses (p = 0.04). The platelet counts were significantly lower in the patients with BD who committed offenses compared to nonoffending patients with BD (p = 0.015). The HDL-c levels were significantly lower in the patients with BD who have committed offenses than those of nonoffending patients with BD (p < 0.001). Bipolar disorder, not receiving active psychiatric treatment, having a diagnosis of bipolar manic episodes, and having low platelet and HDL values constitute a risk of involvement in crime. Conclusions: The present study emphasizes the role of systemic inflammation in the pathophysiology of patients with BD with and without criminal offenses and the relationship between inflammation and criminal behavior.

Aim of the study: The purpose of the study is to investigate the cyberchondria attitudes, health anxiety and their correlation with each other in Fibromyalgia Syndrome (FMS) patients.Subject or material and methods: 68 patients diagnosed with FMS according to the American College of Rheumatology (ACR) 2010 diagnostic criteria and 68 healthy individuals with similar sociodemographic characteristics and meeting the study criteria were included in the study. Sociodemographic Data Form, Cyberchondria Severity Scale (CSS), Fibromyalgia Impact Questionnaire (FIQ), and Health Anxiety Inventory-Short Version (HAI) were administered to all participants.Results: The sub-dimensions of the CSS total, distress, excessiveness, reassurance, and mistrust of medical professional and the HAI body sub-dimension and total score of the patient group were found to be significantly higher than the scores of the control group (p<0.001). There is a significant positive correlation between HAI total score and FIQ score (p= 0.018) (r=.285). A positive and significant relationship was found between the CSS-total score and the HAI sub-dimensions and total score (p= 0.002, r=.377).Discussion: Our study shows that health anxiety and cyberchondria are high in patients with FMS and that disease severity and health anxiety increase in direct proportion. Due to these results, it may be wise to periodically check the cyberchondria and health anxiety levels of these patients and to include psychiatric view in the treatment of the patients.Conclusions: Doctors can refer patients who have health concerns and who have comorbid psychiatric symptoms for psychoeducation, as well as protect patients from uncontrolled anxiety by referring them only to reliable and accurate online sites.

Anger rumination,non-suicidal self-injury,rumination,suicide

The aim of this study was to compare the complete blood cell count parameters of patients with methamphetamine and synthetic cannabis use disorder (MCUD), a condition that has recently exhibited a gradual increase in prevalence, with those of healthy subjects. In total, 76 patients diagnosed with MCUD and 78 healthy controls were included in the study. Venous blood samples were collected from all participants at presentation for laboratory examination. The rate of mono- and poly-substance users in the patient group was 14.5% and 85.5%, respectively. The average duration of methamphetamine (METH) use in the patient group is 3.0 ± 1.9 years. White blood cell (P < .001), PLT (P = .005), monocyte count (P < .001), basophil count (P < .001), neutrophil count (P < .001), lymphocyte count (P < .001) basophil/lymphocyte ratio (BLR) (P = .04), SII (P = .006), and SIRI (P = .001) values were significantly higher. In contrast Hgb (P = .043), Hct (P = .002), monocyte percentage (P = .004), and RBC (P = .021) values were significantly lower in the MCUD group compared to the control group. There was a significant positive correlation between neutrophil/lymphocyte ratio and platelet/lymphocyte ratio (r = .552 P < .001) and between systemic immune inflammatory index (SII) and systemic inflammation response index (SIRI) (r = 0.580 P < .001). Methamphetamine and cannabis may affect the levels of inflammatory markers and SII and SIRI values through various mechanisms. To the best of our knowledge, this is the first study in the relevant literature, which investigated SII and SIRI values in patients with MCUD, therefore, the results can contribute to the future development of immune system-related markers in this field.

Depression,arterial stiffness,cardiovascular risk,elastic modulus,intimamedia thickness

Obsessive‒compulsive personality disorder (OCPD) is characterized by a rigid need for control, orderliness, and perfectionism, often impairing functionality. Traits such as striving for an "ideal" figure can lead to orthorexic tendencies, characterized by an obsessive focus on healthy eating, which can result in significant social, psychological, and physical complications. This study investigates the presence of orthorexic tendencies in individuals with OCPD and examines whether these tendencies are predicted by metacognition and perfectionism, with a focus on the mediating role of metacognition. The study included 73 patients diagnosed with OCPD through the DSM-5 Structured Clinical Interview (SCID-5-PD) and 73 healthy controls matched by age, sex, and education level. Perfectionism, orthorexia, and metacognition were assessed via the Frost Multidimensional Perfectionism Scale (FMPS), Meta-Cognition Questionnaire-30 (MCQ-30), and ORTO-11 scale. Pearson correlation, linear regression, and mediation analyses were conducted to explore these relationships. OCPD patients had lower BMIs and higher scores for perfectionism, orthorexia, and metacognitive activity than did the control group. A negative correlation was found between the FMPS and ORTO-11 scores. MCQ scores were positively correlated with FMPS scores and negatively correlated with ORTO-11 scores. In the mediation analysis, metacognition was found to have a partial mediating effect on the relationship between perfectionism and orthorexia. Perfectionism and dysfunctional metacognition significantly contribute to orthorexic tendencies in individuals with OCPD. These findings suggest that metacognitive therapy may effectively address and reduce orthorexic behaviors in this population.