The stability of RNA is a critical factor in determining its functionality and degradation in the cell. In recent years, it has been shown that the stability of RNA depends on a complex interaction of external and internal factors. External conditions, such as temperature fluctuations, the level of acidity of the environment, the presence of various substances and ions, as well as the effects of oxidative stress, can change the structure of RNA and affect its stability. Internal factors, including the specific structural features of RNA and its interactions with protein molecules, also have a significant impact on the regulation of the stability of these molecules. In this article, we review the main factors influencing RNA stability, since understanding the factors influencing this extremely complex process is important not only for understanding the regulation of expression at the RNA level but also for developing new methods for isolating and stabilizing RNA in preparation for creating biobanks of genetic material. We reviewed a modern solution to this problem and formulated basic recommendations for RNA storage aimed at minimizing degradation and damage to the molecule.

В рамках научно-исследовательской работы проведены испытания двухкомпонентного набора деконтаминационных растворов «ДКР», обозначенных «ДКР-1» и «ДКР-2», с целью оценки их влияния на генетический материал возбудителя коронавирусной инфекции (SARS-CoV-2), а также разработки методических подходов в отношении уничтожения возбудителя коронавирусной инфекции (SARS-CoV-2). Экспертное исследование проведено на базе ФБУН «Ростовский научно-исследовательский институт микробиологии и паразитологии» Роспотребнадзора и ФИЦ ««Южный научный центр Российской академии наук».

Reactions and biological processes in biobetone represent the integration of biological and technological aspects, which opens up new prospects for research in the field of biomineral-ization of building materials. The object of the study is biobetone, in which various biological and molecular interactions of its constituent components occur. A detailed description of the methodology of the literature research was carried out and the current world research on the use of bioadditives in biobetone was systematized. A review was conducted of research in the field of biomineralization, biocementation and its pathways through which precipitation of calcium carbonate can occur. The hydrolysis of urea and the mechanism of self-healing of biobetone are considered. The problems of self-healing of biobetone have been identified and recommenda-tions for further research have been proposed.