Despite growing interest in controlled-release N fertilizers (CRNFs) because of their potential for enhancing nitrogen use efficiency (NUE) and economic returns, their comprehensive impact on machine-transplanted rice remains to be understudied. To address this gap, here, we present a two-year field experiment that assessed the impact of CRNF using mechanical deep placement fertilization (DPF) on rice cultivation. The study involved three CRNF types (bulk blending fertilizer (BBF), polymer-coated urea (PCU), and sulfur-coated urea (SCU)) and two fertilization methods (DPF and broadcast application), with a high-yield split fertilization of urea as a control (CK). The results showed that DPF, especially with SCU, greatly enhanced soil NH₄⁺-N concentrations, NUE, rice yield, and economic benefits compared to broadcast application. BBF consistently exhibited superior NUE and notable economic benefits, regardless of the application method used. Conversely, single-time application of PCU was less favorable for rice growth. In conclusion, for optimal economic benefits and NUE, DPF combined with single-time application of SCU is recommended. However, if deep application is not feasible and only broadcasting is possible in rice cultivation, BBF emerges as the ideal choice for both high NUE and significant economic returns. This research offers insights for improved nitrogen management in machine-transplanted rice, effectively optimizing yield, NUE, and profitability.