Background: As the most widespread eating disorder in the world now, binge eating disorder (BED) is a mental condition characterized by recurrent periods of excessive food consumption and an inability to regulate one’s portion sizes. The utilization of a bupropion–naltrexone (NB) combination has been suggested as a potential therapeutic approach for BED. Assessing the effectiveness of NB in the treatment of BED and its accompanying obesity is the purpose of this research. Methods: A comprehensive search was conducted in order to obtain any pertinent articles. PubMed, Scopus, Web of Science, and Cochrane Clinical Trials were consulted against in the databases that were searched. In our final meta-analysis, we incorporated interventional or observational studies that documented the effects of NB therapy for binge eating in adults. We also examined the difference in the mean change between the NB and placebo groups, as well as the disparity in outcomes before and after treatment. Results: This study shows that the use of an NB combination is associated with a statistically significant reduction in the weight, BMI, and Binge Eating Scale (BES) of the patients compared to their weight before treatment with MD: −8.52 (95% CI: −10.01–−6.94, p < 0.00001), MD: −4.95 (95%CI: −9.72–−0.17, p = 0.04), and MD: −7.66 (95%CI: −14.36–0.96, p = 0.02), respectively. The absolute mean change was statistically significantly higher in the drug combination group compared to the placebo group. Conclusions: NB showed efficacy in the improvement of the weight and psychiatric symptoms associated with BED and this provides a promising treatment option.

We conducted a comprehensive systematic review and meta-analysis of RCTs and observational studies comparing the effectiveness and safety of tirofiban as an adjunct to endovascular thrombectomy (EVT) in patients with large vessel occlusion (LVO) ischemic stroke. We performed electronic searches across Medline through PubMed, Cochrane Central Register of Controlled Trials, Scopus, and Web of Science from inception to October 2024. Statistical analysis was conducted using RevMan software (version 5.4.1). Odds ratios (OR) were used for dichotomous outcomes and mean differences (MD) for continuous outcomes under 95% confidence intervals (CI). A total of 30 studies (28 cohort studies and 2 RCTs) were included in the systematic review. Of these, 28 studies comprising 7,427 cases contributed data for the analysis of symptomatic intracranial hemorrhage (sICH). There was no significant difference between tirofiban and control groups even after doing subgroup analysis based on the route of tirofiban administration (OR 0.93, 95%CI = 0.78 to 1.11). The pooled data revealed no significant difference between both groups (OR 0.92, 95%CI = 0.62 to 1.35) regarding asymptomatic intracranial hemorrhage (AsICH). On doing subgroup analysis based on the route of tirofiban administration, only the tirofiban intravenous (IV)+ intraarterial (IA) group demonstrated a lower probability of having AsICH compared to the control group (OR 0.68, 95%CI= 0.49 to 0.94). Using tirofiban as an adjunct to EVT in patients with LVO stroke is demonstrated to be safe and effective, especially when using IV+IA dosing of tirofiban, which reduced the risk of AsICH, 3-month mortality and increased the incidence of good functional outcomes presented by modified Rankin score.