Ulcerative colitis (UC) is a non-specific chronic inflammatory disease with lesions located in the colon and rectum. The aim of this study was to evaluate the anti-inflammatory effects of exopolysaccharide-1 (EPS-1) isolated by L. helveticus KLDS1.8701 on UC. The anti-inflammatory effects of EPS-1 were studied using dextran sulphate sodium (DSS)-induced UC model. In vivo results showed that EPS-1 administration significantly ameliorated weight loss, colon shortening, disease activity index (DAI) score, myeloperoxidase (MPO) activity, and colon tissue damage. In addition, EPS-1 administration significantly decreased the levels of pro-inflammatory cytokines and increased levels of anti-inflammatory cytokines. Meanwhile, EPS-1 administration significantly up-regulated the expression of tight junction proteins and mucin. Furthermore, EPS-1 administration modulated gut microbiota composition caused by DSS and increased the short-chain fatty acids (SCFAs) levels. Collectively, our study showed the alleviative effects of EPS- isolated by L. helveticus KLDS1.8701 on DSS-induced UC via alleviating intestinal inflammation, improving mucosal barrier function, and modulating gut microbiota composition.

In response to the challenges of food spoilage and water pollution caused by pathogenic microorganisms, CeO₂/g-C₃N₄ nanocomposites were synthesized via one-step calcination using thiourea and urea as precursors. Steady-state photoluminescence (PL) spectroscopy analysis demonstrated that 8 wt% CeO₂/g-C₃N₄ exhibited superior electron–hole separation efficiency. Quantitative antimicrobial assays demonstrated that the nanocomposites displayed enhanced bactericidal activity against Escherichia coli, Ralstonia solanacearum, and Staphylococcus aureus. Electron paramagnetic resonance (EPR) spectroscopy analysis verified the generation of hydroxyl radicals (·OH) and superoxide radicals (·O₂⁻) during the photo-Fenton process utilizing CeO₂/g-C₃N₄ nanocomposites. Additionally, 8 wt% CeO₂/g-C₃N₄ nanocomposites demonstrated enhanced photocatalytic degradation of rhodamine B (RhB) and tetracycline hydrochloride (TC) under photo-Fenton conditions.