Iris Quasar Grunwald

Prof. Dr. Iris Quasar Grunwald


Research Focus & Metrics

Academic Career Length

8Years (2019-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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19 June 2019 in Cerebrovascular Diseases
Verified
Journal Article
Open access
PDF file
IGIris Quasar Grunwald
Iris Quasar Grunwald
JKJohann Kulikovski
Johann Kulikovski
WRWolfgang Reith
Wolfgang Reith
SGStephen Gerry
Stephen Gerry
RNRafael Namias
Rafael Namias
KFKlaus Fassbender
Klaus Fassbender
Computed tomography angiography (CTA) collateral scoring can identify patients most likely to benefit from mechanical thrombectomy and those more likely to have good outcomes and ranges from 0 (no collaterals) to 3 (complete collaterals). In this study, we used a machine learning approach to categorise the degree of collateral flow in 98 patients who were eligible for mechanical thrombectomy and generate an e-CTA collateral score (CTA-CS) for each patient (e-STROKE SUITE, Brainomix Ltd., Oxford, UK). Three experienced neuroradiologists (NRs) independently estimated the CTA-CS, first without and then with knowledge of the e-CTA output, before finally agreeing on a consensus score. Addition of the e-CTA improved the intraclass correlation coefficient (ICC) between NRs from 0.58 (0.46–0.67) to 0.77 (0.66–0.85, p = 0.003). Automated e-CTA, without NR input, agreed with the consensus score in 90% of scans with the remaining 10% within 1 point of the consensus (ICC 0.93, 0.90–0.95). Sensitivity and specificity for identifying favourable collateral flow (collateral score 2–3) were 0.99 (0.93–1.00) and 0.94 (0.70–1.00), respectively. e-CTA correlated with the Alberta Stroke Programme Early CT Score (Spearman correlation 0.46, p < 0.001) highlighting the value of good collateral flow in maintaining tissue viability prior to reperfusion. In conclusion, ­e-CTA provides a real-time and fully automated approach to collateral scoring with the potential to improve consistency of image interpretation and to independently quantify collateral scores even without expert rater input.

1 April 2023 in Cardiovascular Revascularization Medicine
Verified
Journal Article
Open access
IGIris Quasar Grunwald
Iris Quasar Grunwald
KMKlaus Mathias
Klaus Mathias
SBStefan Bertog
Stefan Bertog
KSKenneth V. Snyder
Kenneth V. Snyder
HSHorst Sievert
Horst Sievert
NHNelson L. Hopkins
Nelson L. Hopkins
Today, endovascular treatment (EVT) is the therapy of choice for strokes due to acute large vessel occlusion, irrespective of prior thrombolysis. This necessitates fast, coordinated multi-specialty collaboration. Currently, in most countries, the number of physicians and centres with expertise in EVT is limited. Thus, only a small proportion of eligible patients receive this potentially life-saving therapy, often after significant delays. Hence, there is an unmet need to train a sufficient number of physicians and centres in acute stroke intervention in order to allow widespread and timely access to EVT. To provide multi-specialty training guidelines for competency, accreditation and certification of centres and physicians in EVT for acute large vessel occlusion strokes. The World Federation for Interventional Stroke Treatment (WIST) consists of experts in the field of endovascular stroke treatment. This interdisciplinary working group developed competency - rather than time-based - guidelines for operator training, taking into consideration trainees' previous skillsets and experience. Existing training concepts from mostly single specialty organizations were analysed and incorporated. The WIST establishes an individualized approach to acquiring clinical knowledge and procedural skills to meet the competency requirements for certification of interventionalists of various disciplines and stroke centres in EVT. WIST guidelines encourage acquisition of skills using innovative training methods such as structured supervised high-fidelity simulation and procedural performance on human perfused cadaveric models. WIST multispecialty guidelines outline competency and quality standards for physicians and centres to perform safe and effective EVT. The role of quality control and quality assurance is highlighted. The World Federation for Interventional Stroke Treatment (WIST) establishes an individualized approach to acquiring clinical knowledge and procedural skills to meet the competency requirements for certification of interventionalists of various disciplines and stroke centres in endovascular treatment (EVT). WIST guidelines encourage acquisition of skills using innovative training methods such as structured supervised high-fidelity simulation and procedural performance on human perfused cadaveric models. WIST multispecialty guidelines outline competency and quality standards for physicians and centers to perform safe and effective EVT. The role of quality control and quality assurance is highlighted. The WIST 2023 Guidelines are published simultaneously in Europe (Adv Interv Cardiol 2023).

6 May 2025 in Medicina
Verified
Journal Article
Open access
PDF file
Anna PodlasekAnna Podlasek
Anna Podlasek
Ivo PetrovIvo Petrov
Ivo Petrov
ZSZoran Stankov
Zoran Stankov
KSKenneth Snyder
Kenneth Snyder
CACarlos Alejandro Alvarez
Carlos Alejandro Alvarez
IGIris Quasar Grunwald
Iris Quasar Grunwald
Background and Objectives: Thermography is a non-invasive diagnostic technique that measures skin surface temperatures to reflect normal or abnormal physiology. This review explores the clinical utility of thermography in diagnosing and monitoring stroke, with an emphasis on its clinical applications. Materials and Methods: This systematic review followed PRISMA guidelines, with a protocol published prior to analysis. Three databases were screened up to end of 2024. Article selection was conducted in two stages: title and abstract screening using Rayyan®, followed by full-text eligibility assessment. Discrepancies were resolved through consensus. Risk of bias assessment was performed with ROBINS-I. Narrative synthesis was planned in addition to descriptive statistics. Results: A total of 20 studies were included after screening 277 records. Thermography emerged as a promising tool for stroke patients in both the acute and chronic phases. In the acute phase, it demonstrated potential in detecting early signs of carotid occlusive disease by identifying temperature differences in the forehead or neck regions. Additionally, thermography contributed to the differential diagnosis of Wallenberg syndrome. In the chronic phase, it exhibited clinical utility in monitoring rehabilitation progress. Conclusions: Thermography shows promise as a non-invasive tool for stroke assessment and monitoring. While preliminary studies suggest physiological relevance, its clinical utility remains investigational and requires further validation.

1 January 2023 in Advances in Interventional Cardiology
Verified
Journal Article
Open access
IGIris Quasar Grunwald
Iris Quasar Grunwald
KMKlaus Mathias
Klaus Mathias
SBStefan Bertog
Stefan Bertog
KSKenneth V. Snyder
Kenneth V. Snyder
HSHorst Sievert
Horst Sievert
NHNelson L. Hopkins
Nelson L. Hopkins
Introduction: Today, endovascular treatment (EVT) is the therapy of choice for strokes due to acute large vessel occlusion, irrespective of prior thrombolysis. This necessitates fast, coordinated multi-specialty collaboration. Currently, in most countries, the number of physicians and centres...

26 January 2024 in Clinical Radiology
Verified
Journal Article
Closed access
IGIris Quasar Grunwald
Iris Quasar Grunwald
PMP. Musialek
P. Musialek
APA. Podlasek
A. Podlasek
HSH. Sievert
H. Sievert
KMK. Mathias
K. Mathias
LHL.N. Hopkins
L.N. Hopkins

17 September 2024
Verified
Book Chapter
Closed access
PDF file
TYTeodora Yaneva-Sirakova
Teodora Yaneva-Sirakova
Anna PodlasekAnna Podlasek
Anna Podlasek
IPIvo Petrov
Ivo Petrov
IGIris Quasar Grunwald
Iris Quasar Grunwald