This study examines how innovative work behavior (IWB) is affected by job insecurity (JI). The study also explores knowledge-hiding behavior (KHB) and team anti-citizenship behavior (TAB) as mediators. Data were collected from employees working in Egypt’s five-star hotels and category (A) travel agencies. There were 457 valid responses and they were analyzed using PLS-SEM. The findings demonstrated that there is a negative relationship between job insecurity and employee innovative work behavior. There were positive relationships between job insecurity with knowledge-hiding behavior and team anti-citizenship behavior. The findings also revealed a negative relationship between knowledge-hiding behavior and team anti-citizenship behavior with employee innovative work behavior. In addition, findings revealed that knowledge-hiding behavior mediates the relationship between JI and IWB. Contrary to the hypothesized model of the study, team anti-citizenship behavior did not mediate the relationship between JI and IWB. This research contributes to the studies on JI, KHB, and TAB in terms of IWB, specifically in the hospitality and tourism context. It also includes suggestions for coping with JI, KHB, and TAB in hotel and tourism enterprises, which may promote IWB and the overall workplace environment.