The basins of the Indus and Ganges rivers cover 2.20 million km² and are inhabited by more than a billion people. The region is under extreme pressures of population and poverty, unregulated utilization of the resources and low levels of productivity. The needs are: (1) development policies that are regionally differentiated to ensure resource sustainability and high productivity; (2) immediate development and implementation of policies for sound groundwater management and energy use; (3) improvement of the fragile food security and to broaden its base; and (4) policy changes to address land fragmentation and improved infrastructure. Meeting these needs will help to improve productivity, reduce rural poverty and improve overall human development.

Climate change (CC) and land-use change (LUC) will alter a basin’s hydrological processes and water balance. Quantifying their significance is imperative in formulating appropriate countermeasures and management plans. This study assesses projected changes in hydrological variables under CC and LUC scenarios to provide multi-dimensional insight into water balance relevant to an agricultural watershed in Northeast Thailand. The soil and water assessment tool (SWAT) is utilized to simulate hydrological variables (evapotranspiration, soil moisture, surface runoff, and water yield) for the baseline (1981–2010) and the near-future (2021–2050) after calibrating the model. CC projections considering the CMIP6 model ensemble for the high-emission scenario (SSP5-8.5) show the annual rainfall may not change significantly (0.5% increase compared to baseline). However, the surface runoff will likely increase by 33% due to the projected increase in rainfall intensity and extremes. The increase in urban areas due to LUC for the business as usual (BAU) scenario is also expected to boost surface runoff by 38–87%. Similarly, the LUC scenario with forest expansion will increase evapotranspiration by up to 1.3%. While CC is anticipated to raise water yield by 11%, LUC may reduce it by 6%. Under the combined scenario, the yield is expected to increase by 8%, indicating CC as the dominating driver. The results show that although CC governs the runoff from the basin, land-use change will also impact flows at a monthly scale. Importantly, soil moisture in the future will decrease (8–9%) under both stressors, which will reverberate in the basin’s agricultural livelihood and socioeconomic settings unless the appropriate adaptation measures are implemented.