This page has only limited features, please log in for full access.
Sedentary behavior (SB) is influenced by variations in social, cultural and economic contexts. This study assesses the test–retest reliability and validity of the Youth Leisure-time Sedentary Behavior Questionnaire (YLSBQ), a self-report tool that examines total and domain-specific SB in a cohort of young adults from Colombia. A cross-sectional validation study was conducted among 447 Colombian college students (52.8% men; mean (± standard deviation) age of 19.55 ± 2.54 years). To assess the reliability of the YLSBQ, Kappa statistics (k) were used. A confirmatory factor analysis (CFA) was conducted to determine validity. The Cronbach alpha for the 12 behaviors of the YLSBQ showed a good-to-excellent internal consistency (0.867, ranging from 0.715–0.935). Intraclass correlation coefficient (ICC) indicated that 10 items (83.0%) and two items (17.0%) showed excellent and good reliability, respectively. Furthermore, ICC between the total sedentary time was 0.926 (95% confidence interval [CI] = 0.912 − 0.939), which was interpreted as excellent. The goodness-of-fit tests provided evidence that overall, a four-factor solution was an adequate fit with the time scores. In conclusion, the YLSBQ could be considered a reliable, valid and usable tool for the assessment of SB in young adults in a Latin American country. We found that the psychometric properties of the questionnaire were similar to those of the original Spanish validation study.
Miguel Atencio-Osorio; Hugo Carrillo-Arango; María Correa-Rodríguez; Diego Rivera; José Castro-Piñero; Robinson Ramírez-Vélez. Youth Leisure-Time Sedentary Behavior Questionnaire (YLSBQ): Reliability and Validity in Colombian University Students. International Journal of Environmental Research and Public Health 2021, 18, 7895 .
AMA StyleMiguel Atencio-Osorio, Hugo Carrillo-Arango, María Correa-Rodríguez, Diego Rivera, José Castro-Piñero, Robinson Ramírez-Vélez. Youth Leisure-Time Sedentary Behavior Questionnaire (YLSBQ): Reliability and Validity in Colombian University Students. International Journal of Environmental Research and Public Health. 2021; 18 (15):7895.
Chicago/Turabian StyleMiguel Atencio-Osorio; Hugo Carrillo-Arango; María Correa-Rodríguez; Diego Rivera; José Castro-Piñero; Robinson Ramírez-Vélez. 2021. "Youth Leisure-Time Sedentary Behavior Questionnaire (YLSBQ): Reliability and Validity in Colombian University Students." International Journal of Environmental Research and Public Health 18, no. 15: 7895.
Systemic lupus erythematosus (SLE) is an autoimmune disorder characterized by the formation of antigen–antibody complexes which trigger an immune response. We investigate certain autoantibodies including nucleosome, double-stranded DNA (dsDNA), Smith, ribonucleoprotein, and Sjögren’s syndrome-related antigens, and examine their associations with disease activity, damage accrual, and SLE-related clinical and serological manifestations in patients with SLE. We conducted a cross-sectional study with a total 293 patients (90.4% female, mean age 46.87±12.94 years) and used the Systemic Lupus Erythematosus Disease Activity Index 2000 and Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index (SDI) to evaluate disease activity and disease-related damage, respectively. Systemic Lupus Erythematosus Disease Activity Index scores were significantly higher in anti-nucleosome-positive (3.87±2.72 vs 2.52±2.76, p=0.004) and anti-dsDNA-positive (3.08±2.91 vs 2.04±2.48, p=0.010) patients compared with patients without these antibodies. SDI scores were also significantly higher in anti-nucleosome-positive patients (1.61±1.99 vs 0.89±1.06, p=0.004). The presence of antinucleosome (p=0.019) and anti-dsDNA antibodies (p=0.001) both correlated significantly with the incidence of nephritis; anti-La antibodies were associated with arthritis (p=0.022), and we also observed a relationship between the presence of antinucleosome antibodies and leukopenia (p=0.011). Patients with antinucleosome or anti-dsDNA antibodies had a higher disease activity and were likely to have nephritis. Antinucleosome was also associated with more damage accrual. A greater understanding of these autoantibodies could lead to the development of new approaches to more accurate assessments of SLE.
María Correa-Rodríguez; Gabriela Pocovi-Gerardino; Jose Luis Callejas-Rubio; Raquel Ríos-Fernández; María Martín-Amada; María-Gracia Cruz-Caparrós; Blanca Rueda-Medina; Norberto Ortego-Centeno. Clinical and serological associations of autoantibodies in patients with systemic lupus erythematosus. Journal of Investigative Medicine 2021, 1 .
AMA StyleMaría Correa-Rodríguez, Gabriela Pocovi-Gerardino, Jose Luis Callejas-Rubio, Raquel Ríos-Fernández, María Martín-Amada, María-Gracia Cruz-Caparrós, Blanca Rueda-Medina, Norberto Ortego-Centeno. Clinical and serological associations of autoantibodies in patients with systemic lupus erythematosus. Journal of Investigative Medicine. 2021; ():1.
Chicago/Turabian StyleMaría Correa-Rodríguez; Gabriela Pocovi-Gerardino; Jose Luis Callejas-Rubio; Raquel Ríos-Fernández; María Martín-Amada; María-Gracia Cruz-Caparrós; Blanca Rueda-Medina; Norberto Ortego-Centeno. 2021. "Clinical and serological associations of autoantibodies in patients with systemic lupus erythematosus." Journal of Investigative Medicine , no. : 1.
A cross-sectional study was conducted to assess dietary intake in 92 FMS compared to 96 healthy control patients and to examine the potential associations between daily intake and pain and the severity of symptoms in women with FMS. The tender point count (TPC), the Visual Analog Scale (VAS), and the Revised Fibromyalgia Impact Questionnaire (FIQR) were assessed. FIQ-R correlated negatively with phosphorus ( r = −.230, p = .028), iron ( r = −.320, p = 0.002), zinc ( r = −.238, p = .023), vitamin B1 ( r = −.218, p = .038), vitamin B6 ( r = −.123, p = .012), folic acid ( r = −.250, p = .017), and vitamin C ( r = −.217, p = .039). A negative correlation was also found between VAS pain and the intake of vitamin B6 ( r = −.322, p = .002). Lower intakes of certain micronutrients correlated with higher scores in FIQ-R and a lower intake of vitamin B6 correlated with higher scores in VAS pain, supporting the potential relevance of these micronutrients in the severity of symptoms and in levels of global pain in FMS women.
María Correa-Rodríguez; Blanca Rueda-Medina; Antonio Casas-Barragán; Rosa María Tapia-Haro; Francisco Molina; María Encarnación Aguilar-Ferrándiz. Dietary Intake Assessment, Severity of Symptoms, and Pain in Women with Fibromyalgia. Clinical Nursing Research 2021, 1 .
AMA StyleMaría Correa-Rodríguez, Blanca Rueda-Medina, Antonio Casas-Barragán, Rosa María Tapia-Haro, Francisco Molina, María Encarnación Aguilar-Ferrándiz. Dietary Intake Assessment, Severity of Symptoms, and Pain in Women with Fibromyalgia. Clinical Nursing Research. 2021; ():1.
Chicago/Turabian StyleMaría Correa-Rodríguez; Blanca Rueda-Medina; Antonio Casas-Barragán; Rosa María Tapia-Haro; Francisco Molina; María Encarnación Aguilar-Ferrándiz. 2021. "Dietary Intake Assessment, Severity of Symptoms, and Pain in Women with Fibromyalgia." Clinical Nursing Research , no. : 1.
We aimed to determine the reference values to define an age-specific normal range of controlled attenuation parameter (CAP, a measure of liver steatosis) and liver stiffness measurement (LSM) values assessed by ultrasound-based transient elastography in adolescents without underlying liver disease. A total of 462 participants were included in this cross-sectional study using data from NHANES 2017–2018. LSM and CAP were carried out using the FibroScan® M-probe. Anthropometric, metabolic and hematological parameters were measured. The median CAP was 199.0 dB/m (150.0–245.0 dB/m, 10th to 90th percentiles) and the median LSM was 4.7 kPa (3.4–6.3 kPa, 10th to 90th percentiles) for ages 12–19.9 years. Regression analyses show that the CAP and LSM were not positively correlated with age (boys CAP R2 = 0.001, p = 0.576 and LSM R2 = 0.012, p = 0.096; girls CAP R2 = 0.011, p = 0.113 and LSM R2 = 0.006, p = 0.236). Finally, CAP was positively associated with LSM in girls (β = 0.189, p = 0.005) but not in boys (β = −0.083, p = 0.202). The reference values indicated here for LSM and CAP will help in the screening of adolescents between ages 12 and 19.9 years and might serve as a useful method for identifying those youth at high risk of nonalcoholic fatty liver disease.
Robinson Ramírez-Vélez; Antonio García-Hermoso; María Correa-Rodríguez; Mikel Izquierdo. Defining values for controlled attenuation parameter and liver stiffness in youth without liver disease. Pediatric Research 2021, 1 -9.
AMA StyleRobinson Ramírez-Vélez, Antonio García-Hermoso, María Correa-Rodríguez, Mikel Izquierdo. Defining values for controlled attenuation parameter and liver stiffness in youth without liver disease. Pediatric Research. 2021; ():1-9.
Chicago/Turabian StyleRobinson Ramírez-Vélez; Antonio García-Hermoso; María Correa-Rodríguez; Mikel Izquierdo. 2021. "Defining values for controlled attenuation parameter and liver stiffness in youth without liver disease." Pediatric Research , no. : 1-9.
Osteoporosis is a common comorbidity in patients with systemic lupus erythematosus (SLE), but the potential contribution of disease-associated factors to bone status in SLE is not well known because the reported risk factors from different studies differ greatly. We aimed to examine frequency of reduced bone mass in women with SLE, and determine their potential associations with disease activity, damage accrual and SLE-related clinical markers. A cross-sectional study including 121 Caucasian pre-menopausal and postmenopausal women was conducted (mean age 49.2 ± 12.4 years). The SLE Disease Activity Index (SLEDAI-2 K) and the SDI Damage Index were used to assess disease activity and disease-related damage, respectively. Bone mineral density (BMD) of the left femoral neck and lumbar spine (L2–L4) were measured by dual-energy X-ray absorptiometry. Ten patients (8.3%) had osteoporosis, 63 (52.1%) patients had osteopenia and 6.8% of women had history of previous fracture. Patients with low bone mass had a significantly higher mean SDI (1.3 ± 1.2 versus 0.7 ± 1.0 p = 0.003). T-score at lumbar spine was inversely correlated with SDI score (r = -0.222, p = 0.014) and complement C3 level ( r = −0.206, p = .024). SDI scores were significantly different between patients with osteoporosis, osteopenia, and normal BMD after adjusting for covariates ( p = .004). There is a high prevalence of low BMD in Caucasian women with SLE, and this status was associated with higher damage accrual scores, supporting that disease damage may itself be a major contributor to the low BMD. Women with SLE with organ damage require regular bone status monitoring to prevent further musculoskeletal damage.
María Correa-Rodríguez; Gabriela Pocovi-Gerardino; José-Luis Callejas-Rubio; Raquel Ríos-Fernández; Blanca Rueda-Medina; Norberto Ortego-Centeno. Disease Damage Accrual and Low Bone Mineral Density in Female Patients with Systemic Lupus Erythematosus. Biological Research For Nursing 2021, 1 .
AMA StyleMaría Correa-Rodríguez, Gabriela Pocovi-Gerardino, José-Luis Callejas-Rubio, Raquel Ríos-Fernández, Blanca Rueda-Medina, Norberto Ortego-Centeno. Disease Damage Accrual and Low Bone Mineral Density in Female Patients with Systemic Lupus Erythematosus. Biological Research For Nursing. 2021; ():1.
Chicago/Turabian StyleMaría Correa-Rodríguez; Gabriela Pocovi-Gerardino; José-Luis Callejas-Rubio; Raquel Ríos-Fernández; Blanca Rueda-Medina; Norberto Ortego-Centeno. 2021. "Disease Damage Accrual and Low Bone Mineral Density in Female Patients with Systemic Lupus Erythematosus." Biological Research For Nursing , no. : 1.
Debriefing is the reflective process following the simulation experience. We aimed to compare the debriefing assessment and debriefing satisfaction perceived by nursing students who underwent different debriefing methods. An experimental study conducted on three groups (instructor-led debriefing, peer debriefing, and combined debriefing) was performed for 177 nursing students. Differences in the debriefing satisfaction were assessed using the Clinical Experience Simulation scale, the Visual Analogue scale, and the Debriefing Assessment for Simulation in Healthcare (DASH). VAS scores for satisfaction differed significantly between the instructor-led debriefing, peer debriefing, and combined debriefing groups. In the Clinical Experience Simulation scale, the combined debriefing group was significantly higher compared with instructor-led debriefing. The total score for DASH was significantly higher in the combined debriefing group compared with instructor-led debriefing, and in instructor-led debriefing compared with peer debriefing. Combining debriefing after a simulation session improves the debriefing satisfaction and the perceived debriefing assessment among nursing students. [J Nurs Educ. 2021;60(2):90-95.].
Blanca Rueda-Medina; Jacqueline Schmidt-Ríovalle; Emilio González-Jiménez; Ángel Fernández-Aparicio; María Encarnación Aguilar-Ferrándiz; María Correa-Rodríguez. Peer Debriefing Versus Instructor-Led Debriefing for Nursing Simulation. Journal of Nursing Education 2021, 60, 90 -95.
AMA StyleBlanca Rueda-Medina, Jacqueline Schmidt-Ríovalle, Emilio González-Jiménez, Ángel Fernández-Aparicio, María Encarnación Aguilar-Ferrándiz, María Correa-Rodríguez. Peer Debriefing Versus Instructor-Led Debriefing for Nursing Simulation. Journal of Nursing Education. 2021; 60 (2):90-95.
Chicago/Turabian StyleBlanca Rueda-Medina; Jacqueline Schmidt-Ríovalle; Emilio González-Jiménez; Ángel Fernández-Aparicio; María Encarnación Aguilar-Ferrándiz; María Correa-Rodríguez. 2021. "Peer Debriefing Versus Instructor-Led Debriefing for Nursing Simulation." Journal of Nursing Education 60, no. 2: 90-95.
Our aim was to analyse body core temperature and peripheral vascular microcirculation at skin hypothenar eminence of the hands and its relationship to symptoms in fibromyalgia syndrome (FMS). A total of 80 FMS women and 80 healthy women, matched on weight, were enrolled in this case–control study. Thermography and infrared thermometer were used for evaluating the hypothenar regions and core body temperature, respectively. The main outcome measures were pain pressure thresholds (PPTs) and clinical questionnaires. Significant associations were observed between overall impact [ β = 0.033; 95% confidence interval (95%CI) = 0.003, 0.062; p = 0.030], daytime dysfunction ( β = 0.203; 95%CI = 0.011, 0.395; p = 0.039) and reduced activity ( β = 0.045; 95%CI = 0.005, 0.085; p = 0.029) and core body temperature in FMS women. PPTs including greater trochanter dominant ( β = 0.254; 95%CI = 0.003, 0.504; p = 0.047), greater trochanter non-dominant ( β = 0.650; 95%CI = 0.141, 1.159; p = 0.013), as well as sleeping medication ( β = −0.242; 95%CI = −0.471, −0.013; p = 0.039) were also associated with hypothenar eminence temperature. Data highlighted that FMS women showed correlations among body core temperature and hand temperature with the clinical symptoms.
Antonio Casas-Barragán; Francisco Molina; Rosa María Tapia-Haro; María Carmen García-Ríos; María Correa-Rodríguez; María Encarnación Aguilar-Ferrándiz. Association of core body temperature and peripheral blood flow of the hands with pain intensity, pressure pain hypersensitivity, central sensitization, and fibromyalgia symptoms. Therapeutic Advances in Chronic Disease 2021, 12, 1 .
AMA StyleAntonio Casas-Barragán, Francisco Molina, Rosa María Tapia-Haro, María Carmen García-Ríos, María Correa-Rodríguez, María Encarnación Aguilar-Ferrándiz. Association of core body temperature and peripheral blood flow of the hands with pain intensity, pressure pain hypersensitivity, central sensitization, and fibromyalgia symptoms. Therapeutic Advances in Chronic Disease. 2021; 12 ():1.
Chicago/Turabian StyleAntonio Casas-Barragán; Francisco Molina; Rosa María Tapia-Haro; María Carmen García-Ríos; María Correa-Rodríguez; María Encarnación Aguilar-Ferrándiz. 2021. "Association of core body temperature and peripheral blood flow of the hands with pain intensity, pressure pain hypersensitivity, central sensitization, and fibromyalgia symptoms." Therapeutic Advances in Chronic Disease 12, no. : 1.
Vitamin D has immunosuppressive properties and is considered a therapeutic option, although there is controversy about the role of this vitamin in the pathogenesis of systemic lupus erythematosus (SLE). We aimed to determine the prevalence of vitamin D insufficiency and deficiency and their potential association with disease activity, damage accrual, SLE-related clinical manifestations, and cardiovascular risk factors in SLE patients. A cross-sectional study of 264 patients was conducted (89.4% females; mean age 46.7 ± 12.9 years). The SLE Disease Activity Index (SLEDAI-2 K) and the SDI Damage Index were used to assess disease activity and disease-related damage, respectively. The mean 25(OH)D value was 25.1 ± 13.0 ng/ml. Eleven patients (4.2%) had 25(OH)D <10 (deficiency) and 178 patients (70.6%) had 25(OH)D <30 (insufficiency). In the 25(OH)D deficiency group, SLEDAI was significantly higher than the insufficiency ( p = 0.001) and normal groups ( p < 0.001). Also, patients with vitamin D deficiency presented significantly higher SDI scores than patients with 25(OH)D insufficiency ( p = 0.033) and 25(OH)D normal levels ( p = 0.029). There is a high prevalence of both vitamin D deficiency and insufficiency in Caucasian SLE patients and this status was associated with higher SLEDAI and SDI scores, supporting the impact of vitamin D levels on disease activity and damage accrual in SLE patients. Longitudinal studies on the relationship between vitamin D status and disease activity and progression are therefore required.
María Correa-Rodríguez; Gabriela Pocovi-Gerardino; José-Luis Callejas-Rubio; Raquel Ríos-Fernández; María Martín-Amada; María-Gracia Cruz-Caparrós; Sara DelOlmo-Romero; Norberto Ortego-Centeno; Blanca Rueda-Medina. Vitamin D Levels are Associated with Disease Activity and Damage Accrual in Systemic Lupus Erythematosus Patients. Biological Research For Nursing 2020, 23, 455 -463.
AMA StyleMaría Correa-Rodríguez, Gabriela Pocovi-Gerardino, José-Luis Callejas-Rubio, Raquel Ríos-Fernández, María Martín-Amada, María-Gracia Cruz-Caparrós, Sara DelOlmo-Romero, Norberto Ortego-Centeno, Blanca Rueda-Medina. Vitamin D Levels are Associated with Disease Activity and Damage Accrual in Systemic Lupus Erythematosus Patients. Biological Research For Nursing. 2020; 23 (3):455-463.
Chicago/Turabian StyleMaría Correa-Rodríguez; Gabriela Pocovi-Gerardino; José-Luis Callejas-Rubio; Raquel Ríos-Fernández; María Martín-Amada; María-Gracia Cruz-Caparrós; Sara DelOlmo-Romero; Norberto Ortego-Centeno; Blanca Rueda-Medina. 2020. "Vitamin D Levels are Associated with Disease Activity and Damage Accrual in Systemic Lupus Erythematosus Patients." Biological Research For Nursing 23, no. 3: 455-463.
No prior studies have examined the reliability properties of the 16-item Mediterranean Diet Quality Index (KIDMED) questionnaire among young adults from a non-Mediterranean country. The objective of this study was to determine the psychometric properties in terms of the reliability and validity of the KIDMED questionnaire in young adults from Colombia. A cross-sectional validation study was conducted among 604 Colombian college students (47.51% men and 52.48% women; mean age of 21.60 ± 2.02 years). Kappa statistics were used to assess the reliability of the KIDMED questionnaire. A categorical principal components analysis was used to determine validity. Based on the KIDMED score, 58.4% of students had a good adherence to the Mediterranean diet (MedDiet). Good agreement in the general score of the questionnaire was observed (κ = 0.727, 95% confidence interval = 0.676 to 0.778, p < 0.001). A five-factor model was identified which explained almost 51.38% of the variability, showing the multidimensionality of the questionnaire. In conclusion, this study provides reasonable evidence for the reliability and validity of the KIDMED questionnaire for assessing adherence to MedDiet in college students within a Latin American country. The evaluation of the psychometric properties of this tool in early adulthood and in a non-Mediterranean country will be useful in clinical practice and epidemiological research, since practitioners and health researchers now have a valid and reliable short scale.
Miguel Alejandro Atencio-Osorio; Hugo Alejandro Carrillo-Arango; María Correa-Rodríguez; Andrés Felipe Ochoa-Muñoz; Robinson Ramírez-Vélez. Adherence to the Mediterranean Diet in College Students: Evaluation of Psychometric Properties of the KIDMED Questionnaire. Nutrients 2020, 12, 3897 .
AMA StyleMiguel Alejandro Atencio-Osorio, Hugo Alejandro Carrillo-Arango, María Correa-Rodríguez, Andrés Felipe Ochoa-Muñoz, Robinson Ramírez-Vélez. Adherence to the Mediterranean Diet in College Students: Evaluation of Psychometric Properties of the KIDMED Questionnaire. Nutrients. 2020; 12 (12):3897.
Chicago/Turabian StyleMiguel Alejandro Atencio-Osorio; Hugo Alejandro Carrillo-Arango; María Correa-Rodríguez; Andrés Felipe Ochoa-Muñoz; Robinson Ramírez-Vélez. 2020. "Adherence to the Mediterranean Diet in College Students: Evaluation of Psychometric Properties of the KIDMED Questionnaire." Nutrients 12, no. 12: 3897.
Background and aims The relationship between insulin resistance (IR) and hepatic steatosis (fatty liver) is well known; however, the extent to which the satiety hormone leptin acts as a confounder or mediator in this relationship is uncertain. We examined whether the association between IR and hepatic steatosis is mediated by leptin in Colombian adolescents with excess adiposity. Methods and results A total of 122 adolescents (mean age: 13.4 years; 68% girls) participated in the study. We assessed body composition, hepatic steatosis (as defined by the controlled attenuation parameter [CAP]), cardiometabolic risk factors (body mass index, waist circumference, body composition), biochemical variables (leptin, insulin, glucose, lipid profile, cardiometabolic Z-score, transaminases, etc.), and physical fitness (cardiorespiratory fitness and grip strength). Partial correlation, regression, and mediation analyses were conducted using the Barron and Kenny framework. Results Ninety-two youths (75.4%) had IR. Mediation analysis revealed a positive relationship between Homeostasis Model Assessment-IR (HOMA-IR) and CAP (β dir = 3.414, 95% confidence interval [CI]: 1.012 to 5.816, p < 0.001), which was attenuated when leptin was included in the model, thus indicating that leptin mediates this relationship (β ind = 1.074, 95% CI: 0.349 to 2.686, p < 0.001). The percentage of the total effect mediated by leptin was 21%. Regarding sex, the mediation effect of leptin remains significant among boys (βind = 0.962, 95% CI: 0.009 to 2.615, p < 0.001), but not in girls (β ind = 0.991, 95% CI: 1.263 to 5.483, p = 0.477). Conclusions The findings are clinically relevant to consider leptin levels as a surrogate marker of insulin sensitivity when assessing youths with excess adiposity and/or suspected Nonalcoholic hepatic steatosis or nonalcoholic fatty liver disease (NAFLD).
Robinson Ramírez-Vélez; Katherine González-Ruíz; Emilio González-Jiménez; Jacqueline Schmidt-RioValle; María Correa-Rodríguez; Antonio García-Hermoso; Sara Palomino-Echeverría; Mikel Izquierdo. Serum leptin as a mediator of the influence of insulin resistance on hepatic steatosis in youths with excess adiposity. Nutrition, Metabolism and Cardiovascular Diseases 2020, 31, 1308 -1316.
AMA StyleRobinson Ramírez-Vélez, Katherine González-Ruíz, Emilio González-Jiménez, Jacqueline Schmidt-RioValle, María Correa-Rodríguez, Antonio García-Hermoso, Sara Palomino-Echeverría, Mikel Izquierdo. Serum leptin as a mediator of the influence of insulin resistance on hepatic steatosis in youths with excess adiposity. Nutrition, Metabolism and Cardiovascular Diseases. 2020; 31 (4):1308-1316.
Chicago/Turabian StyleRobinson Ramírez-Vélez; Katherine González-Ruíz; Emilio González-Jiménez; Jacqueline Schmidt-RioValle; María Correa-Rodríguez; Antonio García-Hermoso; Sara Palomino-Echeverría; Mikel Izquierdo. 2020. "Serum leptin as a mediator of the influence of insulin resistance on hepatic steatosis in youths with excess adiposity." Nutrition, Metabolism and Cardiovascular Diseases 31, no. 4: 1308-1316.
Background Fibromyalgia (FM) is a complex syndrome of uncertain etiology, characterized by the presence of widespread pain. Both nitric oxide and enkephalinases modulate pain perception. Objectives The aim of this study was to evaluate the relationships among serum nitric oxide levels, oxytocinase activity and enkephalin-degrading aminopeptidase (EDA) activity with pain-related clinical manifestations in women with fibromyalgia. Methods We performed an observational case study in a population of fifty-eight women diagnosed with fibromyalgia. Serum nitric oxide levels were analyzed by an ozone chemiluminescence-based assay. Both serum oxytocinase and EDA activities were fluorometrically determined. Pain threshold and pain magnitude were evaluated using the Pain Matcher. The pressure pain thresholds were measured using a digital pressure algometer. We used a Visual Analog Scale, the Central Sensitization Inventory, the Revised Fibromyalgia Impact Questionnaire, and the Beck Anxiety Inventory to assess the global level of pain, the symptoms associated with the central sensitization syndrome, the severity of fibromyalgia, and the anxiety level, respectively. Results Multiple linear regression analysis adjusted by age, body mass index, and menopause status revealed significant associations between nitric oxide levels and dominant occiput pressure pain thresholds, non-dominant occiput pressure pain thresholds, and fibromyalgia effects. Significant associations of oxytocinase activity with the visual analog scale and dominant knee pressure pain thresholds were also found. Moreover, results showed a significant association between high EDA activity levels and dominant second rib pressure pain thresholds. Discussion Our data have shown significant relationships of serum nitric oxide levels and oxytocinase and EDA activities with some body pressure pain thresholds, the daily activity level, and the global intensity of pain in women with fibromyalgia. These results suggest that pain, which is the main symptom of this syndrome, may be related to alterations in nitric oxide levels and in oxytocinase and EDA activities in patients with fibromyalgia.
María Encarnación Aguilar-Ferrándiz; Antonio Casas-Barragán; Alma Rus; Rosa María Tapia-Haro; José Manuel Martínez-Martos; Francisco Molina; María Correa-Rodríguez. Associations Among Nitric Oxide and Enkephalinases With Fibromyalgia Symptoms. Nursing Research 2020, 70, E11 -E20.
AMA StyleMaría Encarnación Aguilar-Ferrándiz, Antonio Casas-Barragán, Alma Rus, Rosa María Tapia-Haro, José Manuel Martínez-Martos, Francisco Molina, María Correa-Rodríguez. Associations Among Nitric Oxide and Enkephalinases With Fibromyalgia Symptoms. Nursing Research. 2020; 70 (2):E11-E20.
Chicago/Turabian StyleMaría Encarnación Aguilar-Ferrándiz; Antonio Casas-Barragán; Alma Rus; Rosa María Tapia-Haro; José Manuel Martínez-Martos; Francisco Molina; María Correa-Rodríguez. 2020. "Associations Among Nitric Oxide and Enkephalinases With Fibromyalgia Symptoms." Nursing Research 70, no. 2: E11-E20.
Fibromyalgia syndrome is defined as a complex disease, characterized by chronic widespread musculoskeletal pain and other symptoms. The factors underlying physiopathology of fibromyalgia are not well understood, complicating its diagnosis and management. To evaluate the peripheral vascular blood flow of the skin of the hands and the core body temperature as indirect measures of sympathetic adrenergic activity of the nervous system and its relationship to nitric oxide levels (NO) in women with fibromyalgia compared with healthy controls. Forty-two women with fibromyalgia and 52 healthy women were enrolled in this observational pilot study. We used infrared thermography of the hands and an infrared dermal thermometer to evaluate the peripheral vascular blood flow and tympanic and axillary core body temperature, respectively. We measured NO levels using the ozone chemiluminescence-based method. Two-way analysis of covariance (ANCOVA) showed that the tympanic (P=0.002) and hand temperatures were significantly higher in the patients with fibromyalgia than in the controls (P≤0.001). Significant associations were also found between serum NO levels and minimum temperatures at the dorsal center of the dominant hand (β=-3.501; 95% confidence interval [CI] -6.805, ‑0.198; P= 0.038), maximum temperature (β=-5.594; 95% CI ‑10.106, ‑1.081; P=0.016), minimum temperature (β=-4.090; 95% CI ‑7.905, ‑0.275; P=0.036), and mean temperature (β=-5.519; 95% CI ‑9.933, ‑1.106; P=0.015) of the center of the palm of the non-dominant hand, maximum temperature at the thenar eminence of the dominant hand (β=-5.800; 95% CI ‑10.508, ‑1.092; P=0.017), and tympanic temperature (β=-9.321; 95% CI ‑17.974, ‑0.669; P=0.035) in the controls. Our findings indicate that the women with fibromyalgia showed higher tympanic core body and hand temperature than the healthy controls. Moreover, there were negative associations between hand peripheral vasodilation and NO in the healthy women but not in those with fibromyalgia, suggesting a dysfunction of sympathetic cutaneous neural control.
María Encarnación Aguilar-Ferrándiz; Antonio Casas-Barragán; Rosa Maria Tapia-Haro; Alma Rus; Francisco Molina; María Correa-Rodríguez. Evaluation of sympathetic adrenergic branch of cutaneous neural control throughout thermography and its relationship to nitric oxide levels in patients with fibromyalgia. Journal of Thermal Biology 2020, 95, 102813 .
AMA StyleMaría Encarnación Aguilar-Ferrándiz, Antonio Casas-Barragán, Rosa Maria Tapia-Haro, Alma Rus, Francisco Molina, María Correa-Rodríguez. Evaluation of sympathetic adrenergic branch of cutaneous neural control throughout thermography and its relationship to nitric oxide levels in patients with fibromyalgia. Journal of Thermal Biology. 2020; 95 ():102813.
Chicago/Turabian StyleMaría Encarnación Aguilar-Ferrándiz; Antonio Casas-Barragán; Rosa Maria Tapia-Haro; Alma Rus; Francisco Molina; María Correa-Rodríguez. 2020. "Evaluation of sympathetic adrenergic branch of cutaneous neural control throughout thermography and its relationship to nitric oxide levels in patients with fibromyalgia." Journal of Thermal Biology 95, no. : 102813.
Coronary heart disease is a public health problem and is one of the leading causes of loss of quality of life, disability, and death worldwide. The main procedure these patients undergo is cardiac catheterisation, which helps improve their quality of life, symptoms of myocardial ischemia, and ventricular function, thus helping increase the survival rate of sufferers. It can also, however, lead to physical consequences, including kidney failure, acute myocardial infarction, and stroke. The objective of this study was to analyse how coronary artery bypass grafting (CABG) influences quality of life. A systematic review and meta-analysis were conducted using the CINAHL, PubMed, Scopus, and Cuiden databases in June 2020. A total of 7537 subjects were included, 16 in the systematic review and 3 in the meta-analysis. The studies analysing quality of life using the SF questionnaire showed improvements in the quality of physical and mental appearance, and those using the NHP questionnaire showed score improvements and, in some cases, differences in quality of life between women and men. This operation seems to be a good choice for improving the quality of life of people with coronary pathologies, once the possible existing risks have been assessed.
Jacqueline Schmidt-RioValle; Moath Abu Ejheisheh; María José Membrive-Jiménez; Nora Suleiman-Martos; Luis Albendín-García; María Correa-Rodríguez; José Luis Gómez-Urquiza. Quality of Life After Coronary Artery Bypass Surgery: A Systematic Review and Meta-Analysis. International Journal of Environmental Research and Public Health 2020, 17, 8439 .
AMA StyleJacqueline Schmidt-RioValle, Moath Abu Ejheisheh, María José Membrive-Jiménez, Nora Suleiman-Martos, Luis Albendín-García, María Correa-Rodríguez, José Luis Gómez-Urquiza. Quality of Life After Coronary Artery Bypass Surgery: A Systematic Review and Meta-Analysis. International Journal of Environmental Research and Public Health. 2020; 17 (22):8439.
Chicago/Turabian StyleJacqueline Schmidt-RioValle; Moath Abu Ejheisheh; María José Membrive-Jiménez; Nora Suleiman-Martos; Luis Albendín-García; María Correa-Rodríguez; José Luis Gómez-Urquiza. 2020. "Quality of Life After Coronary Artery Bypass Surgery: A Systematic Review and Meta-Analysis." International Journal of Environmental Research and Public Health 17, no. 22: 8439.
Background and aims The present study investigated the association between abdominal aortic calcification (AAC) and handgrip strength (HGS) and the ability of HGS to predict an increased AAC phenotype in adults. Methods and results The analysis consisted of data for 3140 men and women aged ≥40 years (51.7% women) from the 2013–2014 NHANES. Lateral scans of the thoraco-lumbar spine (L1–L4) were scored for AAC using a validated 8-point scale (AAC-8); subjects with a score of ≥3 were considered at increased risk for cardiovascular disease due to a high AAC phenotype. HGS was assessed using a grip dynamometer. The prevalence of severe AAC in the population was 9.0%. Decline in HGS was associated with higher AAC-8 scores in men and women (p < 0.001). General linear model analysis showed that HGS levels were negatively associated with high AAC (p < 0.001) and AAC-8 status for both sexes. Likewise, for each 5-kg higher HGS, there lower odds of a high AAC phenotype (in men OR = 0.73, CI95%, 0.64–0.84) and (women OR = 0.58, CI95%, 0.47–0.70). Receiver operating characteristic curve analysis showed that the HGS threshold value to detect high risk of AAC in adults was ≥37.3 kg (AUC = 0.692) in men and 25.1 kg (AUC = 0.705) in women. Conclusion Lower muscular strength, as measured by HGS, is associated with higher AAC scores in the U.S. population ≥40 years of age. Accordingly, maintenance of muscular strength during aging may protect adults against vascular calcification, an independent predictor of cardiovascular events. HGS measurement seems to be a valid screening tool for detecting a high ACC phenotype in adults.
Robinson Ramírez-Vélez; Antonio García-Hermoso; María Correa-Rodríguez; Felipe Lobelo; Katherine González-Ruiz; Mikel Izquierdo. Abdominal aortic calcification is associated with decline in handgrip strength in the U.S. adult population ≥40 years of age. Nutrition, Metabolism and Cardiovascular Diseases 2020, 31, 1035 -1043.
AMA StyleRobinson Ramírez-Vélez, Antonio García-Hermoso, María Correa-Rodríguez, Felipe Lobelo, Katherine González-Ruiz, Mikel Izquierdo. Abdominal aortic calcification is associated with decline in handgrip strength in the U.S. adult population ≥40 years of age. Nutrition, Metabolism and Cardiovascular Diseases. 2020; 31 (4):1035-1043.
Chicago/Turabian StyleRobinson Ramírez-Vélez; Antonio García-Hermoso; María Correa-Rodríguez; Felipe Lobelo; Katherine González-Ruiz; Mikel Izquierdo. 2020. "Abdominal aortic calcification is associated with decline in handgrip strength in the U.S. adult population ≥40 years of age." Nutrition, Metabolism and Cardiovascular Diseases 31, no. 4: 1035-1043.
Systemic lupus erythematosus (SLE) is a chronic disease characterized by inflammatory response and abnormal autoimmune disease. Vitamin D is essential in phosphorus-calcium metabolism, has immunosuppressive properties, and is considered a therapeutic option. Controversy exists about the role of this vitamin in the pathogenesis of SLE. Thus, the aim of this study was to investigate the influence of the dietary intake of vitamin D and its supplementation in a cohort of patients with SLE. A cross-sectional study including a total 285 patients with SLE was conducted (248 females and 26 males; mean age 46.99 ± 12.89 years). The SLE disease activity index (SLEDAI-2K) and the SLICC/ACR damage index (SDI) were used to assess disease activity and disease-related damage, respectively. Levels of C-reactive protein (CRP; mg/dL), homocysteine (Hcy; mol/L), anti-double stranded DNA antibodies (anti-dsDNA) (IU/mL), complement C3 (mg/dL), and complement C4 (mg/dL), among other biochemical markers, were measured. The dietary intake of vitamin D and the intake of vitamin D supplement were obtained via a 24-h patient diary. A share of 57.1% of the patients took vitamin D supplements and the average of dietary vitamin D was 2.08 ± 2.94 μg/day. Note that 98.2% of patients did not reach the recommended dietary intakes for vitamin D intake. Multivariate regression analysis revealed that clinical and laboratory variables are not significantly affected by vitamin D intake levels after adjusting for age, gender, energy intake, and medical treatment (immunosuppressants, corticosteroids, and antimalarials). Patients with SLE who took vitamin D supplements had significantly higher serum complement C3 levels compared to patients who did not take them after adjusting for covariates (110.28 ± 30.93 vs. 107.38 ± 24.18; p = 0.018). Our findings suggest a potential impact of supplementation of vitamin D on the activity of SLE. Future longitudinal research on SLE patients, including intervention trials, are required to validate these preliminary data.
María Correa-Rodríguez; Gabriela Pocovi-Gerardino; Irene Medina-Martínez; Sara Del Olmo-Romero; Norberto Ortego-Centeno; Blanca Rueda-Medina. Vitamin D Supplementation Is Associated with Disease Activity in Systemic Lupus Erythematosus Patients. Proceedings of The 1st International Electronic Conference on Nutrients - Nutritional and Microbiota Effects on Chronic Disease 2020, 61, 1 .
AMA StyleMaría Correa-Rodríguez, Gabriela Pocovi-Gerardino, Irene Medina-Martínez, Sara Del Olmo-Romero, Norberto Ortego-Centeno, Blanca Rueda-Medina. Vitamin D Supplementation Is Associated with Disease Activity in Systemic Lupus Erythematosus Patients. Proceedings of The 1st International Electronic Conference on Nutrients - Nutritional and Microbiota Effects on Chronic Disease. 2020; 61 (1):1.
Chicago/Turabian StyleMaría Correa-Rodríguez; Gabriela Pocovi-Gerardino; Irene Medina-Martínez; Sara Del Olmo-Romero; Norberto Ortego-Centeno; Blanca Rueda-Medina. 2020. "Vitamin D Supplementation Is Associated with Disease Activity in Systemic Lupus Erythematosus Patients." Proceedings of The 1st International Electronic Conference on Nutrients - Nutritional and Microbiota Effects on Chronic Disease 61, no. 1: 1.
The objectives of this secondary analysis are (1) to investigate the differential effects of exercise training modalities–high-intensity interval training (HIIT), resistance training (RT), combined training (CT = HIIT + RT), and/or nutritional guidance (NG) alone–on local fat/lean mass indexes in adults with excess of adiposity; (2) to identify the individual patterns of response based on either a clinical criterion of weight loss (≥ 5%) and/or technical error (TE) of measurement of local fat/lean mass indexes; and (3) to assess the individual change for body composition parameters assigned either to HIIT, RT, CT, and/or NG groups utilizing a TE. A 12-week trial was conducted in 55 participants randomized to one of the four interventions. The primary outcome was clinical change in body weight (i.e., weight loss of ≥ 5%). Secondary outcomes included change in ratio of android and gynoid fat mass, as well as local fat and lean mass indexes (arms, trunk, and legs), before and after intervention. The main findings from the current analysis revealed that (i) after 12 weeks of follow-up, significant decreases in several body composition indexes were found including body weight, arm, trunk, and legs fat mass, and android and gynecoid fat mass were observed in HIIT, RT, and CT groups (p < 0.05); (ii) a significant proportion of individuals showed a positive response following 12 weeks of training, led by the HIIT group with 44% and followed by RT with 39% in 9 indexes; (iii) the HIIT group showed lowest rates of adverse responders with (6%); and (iv) the individual patterns of response utilizing clinically meaningful weight loss were not necessarily associated with the corresponding individual training-induced changes in body composition indexes in adults with excess of adiposity. Overall, the study suggests that HIIT has an important ability to reduce the prevalence of non-response to improve body composition indexes.
Robinson Ramírez-Vélez; Mikel Izquierdo; Karem Castro-Astudillo; Carolina Medrano-Mena; Angela Liliana Monroy-Díaz; Rocío Del Pilar Castellanos-Vega; Héctor Reinaldo Triana-Reina; María Correa-Rodríguez. Weight Loss after 12 Weeks of Exercise and/or Nutritional Guidance Is Not Obligatory for Induced Changes in Local Fat/Lean Mass Indexes in Adults with Excess of Adiposity. Nutrients 2020, 12, 2231 .
AMA StyleRobinson Ramírez-Vélez, Mikel Izquierdo, Karem Castro-Astudillo, Carolina Medrano-Mena, Angela Liliana Monroy-Díaz, Rocío Del Pilar Castellanos-Vega, Héctor Reinaldo Triana-Reina, María Correa-Rodríguez. Weight Loss after 12 Weeks of Exercise and/or Nutritional Guidance Is Not Obligatory for Induced Changes in Local Fat/Lean Mass Indexes in Adults with Excess of Adiposity. Nutrients. 2020; 12 (8):2231.
Chicago/Turabian StyleRobinson Ramírez-Vélez; Mikel Izquierdo; Karem Castro-Astudillo; Carolina Medrano-Mena; Angela Liliana Monroy-Díaz; Rocío Del Pilar Castellanos-Vega; Héctor Reinaldo Triana-Reina; María Correa-Rodríguez. 2020. "Weight Loss after 12 Weeks of Exercise and/or Nutritional Guidance Is Not Obligatory for Induced Changes in Local Fat/Lean Mass Indexes in Adults with Excess of Adiposity." Nutrients 12, no. 8: 2231.
Hypertension has been established as a common health condition in young people. Most studies have focused on the impact of body mass index (BMI), but the relationships between body composition parameters and blood pressure in Palestinian children has not previously been investigated. We aimed to analyze the prevalence of overweight/obesity and elevated blood pressure/hypertension and investigate the associations among obesity-related parameters, including anthropometric and body composition markers and blood pressure levels in a population of 971 Palestinian school children (50% girls; mean age 10.3 ± 1.1 years). Anthropometric measurements including height, waist circumference (WC), hip circumference (HC), waist-to-hip ratio (WHR), and waist to height ratio (WHtR) were assessed. A body composition analyzer was used to measure body weight, fat mass, and fat-free mass. Blood pressure including systolic (SBP), diastolic (DBP) and mean arterial pressure (MAP) were measured using a Dinamap vital signs monitor. The prevalence of overweight/obesity was 25.3% in the girls and 23.1% in the boys. 26.3% of the children had elevated systolic blood pressure, or systolic hypertension; whereas 23.4% had elevated diastolic blood pressure, or diastolic hypertension. All obesity-related variables, with the exception of WHR and WHtR, showed statistical differences among the normotension, elevated blood pressure and hypertension groups for systolic and diastolic blood pressure ( p < 0.05). Children with elevated blood pressure or hypertension had significantly higher weight, BMI, WC, HC, fat mass, and fat-free mass values compared to participants with normotension, supporting the direct association between obesity and hypertension in this population. Weight-reduction interventions are essential for reducing the prevalence of childhood hypertension in Palestinian children.
Moath Abu Ejheisheh; María Correa-Rodríguez; Ángel Fernández-Aparicio; Ahmad Batran; María José Membrive-Jiménez; Jacqueline Schmidt-RioValle. Obesity-Related Parameters Are Associated with Blood Pressure in Palestinian Children. Biological Research For Nursing 2020, 23, 151 -159.
AMA StyleMoath Abu Ejheisheh, María Correa-Rodríguez, Ángel Fernández-Aparicio, Ahmad Batran, María José Membrive-Jiménez, Jacqueline Schmidt-RioValle. Obesity-Related Parameters Are Associated with Blood Pressure in Palestinian Children. Biological Research For Nursing. 2020; 23 (2):151-159.
Chicago/Turabian StyleMoath Abu Ejheisheh; María Correa-Rodríguez; Ángel Fernández-Aparicio; Ahmad Batran; María José Membrive-Jiménez; Jacqueline Schmidt-RioValle. 2020. "Obesity-Related Parameters Are Associated with Blood Pressure in Palestinian Children." Biological Research For Nursing 23, no. 2: 151-159.
To evaluate the relationships between the intake of individual antioxidants as well as the dietary antioxidant quality score and obesity-related measures. A cross-sectional study was conducted on 562 young adults. Fat mass, fat-mass percentage, and fat-free mass were measured using a body composition analyzer. The intake of antioxidant nutrients including vitamins C, E, and A, selenium, zinc, and magnesium were calculated based on a 72-hour diet recall interview. We observed significant differences in the vitamin C (88.6 ± 72.6 mg/day vs. 70.7 ± 60.6 mg/day, p = 0.010), vitamin A (635.8 ± 519.8 μg/day vs. 492.6 ± 318.9 μg/day, p = 0.014), and selenium (135.3 ± 88.7 μg/day vs. 139.3 ± 79.3 μg/day, p = 0.034) intake between normal-weight and overweight or obese young adults. When the Dietary Antioxidant Quality Score (DAQS) was analyzed, there were no significant differences between normal-weight versus overweight or obese young adults after adjusting for confounders. Logistic regression analysis revealed that vitamin C intake (odds ratio (OR) 0.995, 95% CI 0.992–0.999, p = 0.013) and vitamin A intake (OR 0.999, 95% CI 0.999–1.000, p = 0.016) were independent predictors of overweight/obesity after adjusting for age, sex and energy intake. In contrast, a higher selenium intake was associated with an increased risk of overweight/obesity (OR 1.003, 95% CI 1.000–1.006, p = 0.034). Future longitudinal investigations of dietary antioxidant intake in relation to the development of obesity would be of interest to better understand the effect of dietary antioxidants on obesity.
María Correa-Rodríguez; Jose Luis Gómez-Urquiza; Irene Medina-Martínez; Emilio González-Jiménez; Jaqueline Schmidt-RioValle; Blanca Rueda-Medina. Low intakes of vitamins C and A are associated with obesity in early adulthood. International Journal for Vitamin and Nutrition Research 2020, 1 -10.
AMA StyleMaría Correa-Rodríguez, Jose Luis Gómez-Urquiza, Irene Medina-Martínez, Emilio González-Jiménez, Jaqueline Schmidt-RioValle, Blanca Rueda-Medina. Low intakes of vitamins C and A are associated with obesity in early adulthood. International Journal for Vitamin and Nutrition Research. 2020; ():1-10.
Chicago/Turabian StyleMaría Correa-Rodríguez; Jose Luis Gómez-Urquiza; Irene Medina-Martínez; Emilio González-Jiménez; Jaqueline Schmidt-RioValle; Blanca Rueda-Medina. 2020. "Low intakes of vitamins C and A are associated with obesity in early adulthood." International Journal for Vitamin and Nutrition Research , no. : 1-10.
Objective To analyse the influence of the Mediterranean diet (Med Diet) on SLE activity, damage accrual and cardiovascular disease risk markers. Methods A cross-sectional study was conducted on 280 patients with SLE [46.9 (12.85) years]. Med Diet adherence was assessed through a 14-item questionnaire on food consumption frequency and habits (total score from 0 to 14 points; higher score is greater adherence to the Med Diet). CRP, homocysteine, SLEDAI-2K (SLE disease activity), and SLICC/ACR and SDI (damage accrual) were measured. Obesity, diabetes mellitus, hypertension and blood lipids, among others, were considered cardiovascular disease risk factors. Results Greater adherence to the Med Diet was significantly associated with better anthropometric profiles, fewer cardiovascular disease risk factors, and lower disease activity and damage accrual scores (P ≤ 0.001 for SLEDAI and SDI). An inverse relationship between the Med Diet score and SLEDAI (P ≥ 0.001; β = −0.380), SDI (P ≤ 0.001; β = −0.740) and hsCRP (P = 0.039; β = −0.055) was observed. The odds ratio for having active SLE (SLEDAI ≥5) or the presence of damage (SDI ≥1) was lower among patients whose Med Diet score was higher (P ≤ 0.001). Finally, greater consumption of Med Diet foods (olive oil, fruits, vegetables, fish, etc.) and abstaining from red meat and meat products, sugars and pastries was associated with less SLE clinical activity and damage. Conclusion Greater adherence to the Med Diet seems to exert a beneficial effect on disease activity and cardiovascular risk in SLE patients. To confirm these findings, further longitudinal studies would be of interest.
Gabriela Pocovi-Gerardino; María Correa-Rodríguez; José-Luis Callejas-Rubio; Raquel Ríos-Fernández; María Martín-Amada; María-Gracia Cruz-Caparros; Blanca Rueda-Medina; Norberto Ortego-Centeno. Beneficial effect of Mediterranean diet on disease activity and cardiovascular risk in systemic lupus erythematosus patients: a cross-sectional study. Rheumatology 2020, 60, 160 -169.
AMA StyleGabriela Pocovi-Gerardino, María Correa-Rodríguez, José-Luis Callejas-Rubio, Raquel Ríos-Fernández, María Martín-Amada, María-Gracia Cruz-Caparros, Blanca Rueda-Medina, Norberto Ortego-Centeno. Beneficial effect of Mediterranean diet on disease activity and cardiovascular risk in systemic lupus erythematosus patients: a cross-sectional study. Rheumatology. 2020; 60 (1):160-169.
Chicago/Turabian StyleGabriela Pocovi-Gerardino; María Correa-Rodríguez; José-Luis Callejas-Rubio; Raquel Ríos-Fernández; María Martín-Amada; María-Gracia Cruz-Caparros; Blanca Rueda-Medina; Norberto Ortego-Centeno. 2020. "Beneficial effect of Mediterranean diet on disease activity and cardiovascular risk in systemic lupus erythematosus patients: a cross-sectional study." Rheumatology 60, no. 1: 160-169.
We aimed to evaluate the relationships between obesity metrics including Body Mass Index (BMI), waist to height ratio (WtHR) and fat mass percentage, and disease activity, damage accrual, inflammation markers and traditional cardiovascular risk factors in SLE patients. A cross-sectional study was conducted on a sample of 275 patients (90.5% females; mean age 46.37±13.85 years). Disease activity was assessed with the SLE disease activity index (SLEDAI-2K), and disease-related organ damage was assessed using the SLICC/ACR damage index (SDI). Biochemical variables of lipids profile, high-sensitivity C-reactive protein (hs-CRP), homocysteine (Hcy), anti-dsDNA titers and complement components C3 and C4 serum levels were measured. Blood pressure and ankle-brachial index (ABI) were also calculated. Significant differences were observed between normal-weight, overweight and obese patients in SLEDAI (2.60±2.48 vs. 2.71±2.65 vs. 3.84±3.02; P=0.004), SDI (0.76±1.10 vs. 1.09±1.24 vs. 1.57±1.54; P=0.002), hsCRP (2.15±2.93 vs. 3.24±3.63 vs. 5.30±5.63 mg/dL; P<0.001), complement C3 level (99.92±24.45 vs. 111.38±27.41 vs. 123.16±28.96 mg/dL; P<0.001), triglycerides serum levels (85.99±41.68 vs. 102.35±50.88 vs. 129.12±61.59 mg/dL; P<0.001) and systolic blood pressure (112.28±16.35 vs. 124.25±17.94 vs. 132.78±16.71 mmHg; P=0.001) after adjusting for age and sex. Patients with SLE who are obese have worse disease activity and damage accrual, higher levels of inflammation markers hs-CRP and C3 complement, increased triglycerides serum levels and systolic blood pressure levels in comparison with overweight or normal weight SLE patients, supporting that optimizing weight in SLE patients should be a potential target to improve SLE outcomes.
María Correa-Rodríguez; Gabriela Pocovi-Gerardino; José-Luis Callejas Rubio; Raquel Ríos Fernández; María Martín Amada; María Cruz Caparrós; Norberto Ortego-Centeno; Blanca Rueda-Medina. The impact of obesity on disease activity, damage accrual, inflammation markers and cardiovascular risk factors in systemic lupus erythematosus. Panminerva Medica 2020, 62, 75 -82.
AMA StyleMaría Correa-Rodríguez, Gabriela Pocovi-Gerardino, José-Luis Callejas Rubio, Raquel Ríos Fernández, María Martín Amada, María Cruz Caparrós, Norberto Ortego-Centeno, Blanca Rueda-Medina. The impact of obesity on disease activity, damage accrual, inflammation markers and cardiovascular risk factors in systemic lupus erythematosus. Panminerva Medica. 2020; 62 (2):75-82.
Chicago/Turabian StyleMaría Correa-Rodríguez; Gabriela Pocovi-Gerardino; José-Luis Callejas Rubio; Raquel Ríos Fernández; María Martín Amada; María Cruz Caparrós; Norberto Ortego-Centeno; Blanca Rueda-Medina. 2020. "The impact of obesity on disease activity, damage accrual, inflammation markers and cardiovascular risk factors in systemic lupus erythematosus." Panminerva Medica 62, no. 2: 75-82.