Background: A malfunction in the melanocortin-4 receptor (MC4R) is associated with obesity in rare genetic syndromes; setmelanotide is a new drug that activates this receptor and is being used to treat severe obesity. This meta-analysis evaluated the efficacy and safety of setmelanotide for weight loss in severe obesity linked to human MC4R deficiency. Methods: We searched PubMed, Embase, and Cochrane for randomized and nonrandomized clinical trials using setmelanotide. We considered a p-value ≤ 0.05 statistically significant. Results: We included 376 patients, of whom 328 (87.2%) received setmelanotide for a mean follow-up of 52 weeks. The mean age was 32.8 (14.67) years. Weight loss was significant (MD −3.52; 95% CI −3.98, −3.05; p = 0.01; I² = 92%), with an average proportion of −6.91% weight loss during treatment. Changes in BMI showed an MD of −10.55 kg/m² in patients > 18 years and −0.61 kg/m² in patients < 18 years (BMI score). However, the drug was associated with a higher risk of skin hyperpigmentation (OR 0.69; 95% CI 0.55, 0.80; p = 0.08). Conclusions: Our results support the use of setmelanotide in treating severe obesity.

Objective: Several studies point to antibacterial properties and beneficial effects of honey on scar tissue formation, which is a low-cost and easy-to-use option. This study aimed to compare honey versus a placebo for cicatrization and pain control of obstetric wounds, and determine if one is superior to the other, in terms of efficacy, through a meta-analysis. Methods: We searched PubMed, Scopus, Cochrane Central Register of Controlled Trials, and Web of Science. Two independent investigators identified randomized controlled trials (RCTs) comparing honey and a placebo for obstetric wounds. The primary outcomes were wound healing and pain control. Results: Five randomized controlled trials and 353 patients were included, of whom, 177 (50.1%) were treated with honey. Differences were not found in the final wound healing between the honey and placebo groups (MD −0.34; 95% CI −1.13, 0.44; p = 0.39); however, there was a decrease in pain levels in the middle of the treatment (SMD −0.54; 95% CI 0.83 to 0.25, p = 0.03), reduction in the use of pain medication (ORR 0.26; 95% CI 0.08, 0.86; p = 0.03), increase in personal satisfaction in women who underwent the intervention (ORR 0.81; 95% CI 0.65, 0.98), and reduction in complications. Conclusion: According to the study results, honey treatments showed greater efficiency and provided benefits to the patients by accelerating wound healing and decreasing reported pain.

Este artigo trata-se de um relato de experiência desenvolvido no contexto da COVID-19, nas redes sociais, Instagram e Facebook, entre o período de 20 de fevereiro de 2020 à 28 de junho de 2020, por meio de postagens educativas e tira-dúvidas sobre o compartilhamento de mensagens falsas a respeito do novo coronavírus e a importância da vacinação em tempos de pandemia. Para isto, foram realizadas postagens todas as semanas propagando novos estudos científicos e conhecimentos atrelados a essas temáticas. Notou-se, por meio do alcance crescente dos perfis, que o combate a desinformação atrelada a promoção da saúde é uma ferramenta indispensável na propagação de conhecimento nos dias atuais e que deve ser cada vez mais utilizada e aprimorada, com o fito de esclarecer uma maior parcela da população.