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Aikaterini Anagnostou
Section of Immunology, Allergy and Retrovirology, Department of Pediatrics, Texas Children’s Hospital, Houston, TX 77030, USA

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Review
Published: 11 June 2021 in Children
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Background: Food allergies are common, affecting 1 in 13 school children in the United States and their prevalence is increasing. Many misconceptions exist with regards to food allergy prevention, diagnosis and management. Objective: The main objective of this review is to address misconceptions with regards to food allergies and discuss the optimal, evidence-based approach for patients who carry this diagnosis. Observations: Common misconceptions in terms of food allergy prevention include beliefs that breastfeeding and delayed introduction of allergenic foods prevent the development of food allergies. In terms of diagnosis, statements such as ‘larger skin prick tests or/and higher levels of food-specific IgE can predict the severity of food-induced allergic reactions’, or ‘Tryptase is always elevated in food-induced anaphylaxis’ are inaccurate. Additionally, egg allergy is not a contraindication for receiving the influenza vaccine, food-allergy related fatalities are rare and peanut oral immunotherapy, despite reported benefits, is not a cure for food allergies. Finally, not all infants with eczema will develop food allergies and epinephrine auto-injectors may unfortunately be both unavailable and underused in food-triggered anaphylaxis. Conclusions and relevance: Healthcare professionals must be familiar with recent evidence in the food allergy field and avoid common misunderstandings that may negatively affect prevention, diagnosis and management of this chronic disease.

ACS Style

Aikaterini Anagnostou. Addressing Common Misconceptions in Food Allergy: A Review. Children 2021, 8, 497 .

AMA Style

Aikaterini Anagnostou. Addressing Common Misconceptions in Food Allergy: A Review. Children. 2021; 8 (6):497.

Chicago/Turabian Style

Aikaterini Anagnostou. 2021. "Addressing Common Misconceptions in Food Allergy: A Review." Children 8, no. 6: 497.

Review
Published: 01 June 2021 in Journal of Asthma and Allergy
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Egg allergy occurs frequently in childhood with a reported prevalence of 1.3– 1.6%. Providing optimal care to egg-allergic patients requires knowledge of the most up-to-date developments in both diagnosis and management, as well as effective communication skills, which will engage the patient in the shared decision-making process. This review aims to provide up-to-date information on egg allergy and also serve as a concise guide on optimal patient diagnosis and management. The field of food allergy has seen multiple advances in recent years, including use of component resolved diagnostics, early egg introduction into the infant diet as a way of preventing egg allergy, baked egg introduction and oral immunotherapy as a form of active therapy. Faced with a variety of options and treatment paths, it is important to ensure that patients and families taking part in the decision-making process have fully understood the potential outcomes and trade-offs and can undertake a detailed discussion of all options that are available to them. Shared decision-making remains the cornerstone of optimal patient care.

ACS Style

Aikaterini Anagnostou. Optimizing Patient Care in Egg Allergy Diagnosis and Treatment. Journal of Asthma and Allergy 2021, ume 14, 621 -628.

AMA Style

Aikaterini Anagnostou. Optimizing Patient Care in Egg Allergy Diagnosis and Treatment. Journal of Asthma and Allergy. 2021; ume 14 ():621-628.

Chicago/Turabian Style

Aikaterini Anagnostou. 2021. "Optimizing Patient Care in Egg Allergy Diagnosis and Treatment." Journal of Asthma and Allergy ume 14, no. : 621-628.

Research article
Published: 01 March 2021 in Allergy and Asthma Proceedings
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Food allergies are common and affect 6‐8% of children in the United States; they pose a significant burden on the quality of life of children with allergy and their caregivers due to multiple daily restrictions. Despite the recommended dietary avoidance, reactions tend to occur due to unintentional exposure to the allergenic food trigger. Fear of accidental ingestions with potentially severe reactions, including anaphylaxis and death, creates anxiety in individuals with food allergy. Oral immunotherapy has emerged as a form of active and potentially disease-modifying treatment for common food allergies encountered in childhood. The efficacy of oral immunotherapy is high, with the majority of participants achieving desensitization and, as a result, protection from trace exposures and improved quality of life. The main risk of oral immunotherapy consists of allergic reactions to treatment. In general, rates of allergic reactions and anaphylaxis are reported to be higher in individuals pursuing therapy options, but most subjects who undergo oral immunotherapy will likely experience mild or moderate reactions during treatment. Adverse events tend to reduce in both frequency and number in the maintenance period. The use of immune modulators alongside oral immunotherapy has been suggested, with the aim to improve efficacy and safety, and to facilitate the overall process. It is evident that the landscape of food allergy management is changing and that the future looks brighter, with different options emerging over time. The process of how to choose the appropriate option becomes a discussion between the clinician and the patient, which involves a joint review of the current medical evidence but also the patient's preference for balancing particular attributes of the treatment. By working together, providers and patients will ensure achievement of the best possible outcome for children with food allergies.

ACS Style

Aikaterini Anagnostou. Weighing the benefits and risks of oral immunotherapy in clinical practice. Allergy and Asthma Proceedings 2021, 42, 118 -123.

AMA Style

Aikaterini Anagnostou. Weighing the benefits and risks of oral immunotherapy in clinical practice. Allergy and Asthma Proceedings. 2021; 42 (2):118-123.

Chicago/Turabian Style

Aikaterini Anagnostou. 2021. "Weighing the benefits and risks of oral immunotherapy in clinical practice." Allergy and Asthma Proceedings 42, no. 2: 118-123.

Review
Published: 01 March 2021 in Journal of Asthma and Allergy
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Food allergies are common, affecting 6– 8% of the children in the United States. There is a significant burden on the quality of life of allergic children and their caregivers, due to multiple dietary, social and psychological restrictions. Peanut allergy affects approximately 2– 5% of the school-age children. Despite the recommended dietary avoidance, reactions tend to occur due to unintentional exposures and the fear of accidental ingestions potentially resulting in anaphylaxis and death, which creates a lot of anxiety in peanut-allergic individuals. Peanut oral immunotherapy (POIT) has emerged as a form of active treatment and has shown high efficacy in research trials with the majority of participants achieving desensitization and protection from trace exposures. An improved quality of life has also been noted following successful POIT. The risks of POIT should be balanced against the benefits resulting from successful treatment for each individual. Rates of allergic reactions and anaphylaxis are reported to be higher in individuals pursuing therapy, but most subjects will experience mild or moderate reactions during treatment. The landscape of peanut allergy management is changing and the future offers more options for patients than were previously available. Shared decision-making, which is the process of how to choose between different available options, becomes an ongoing discussion between the clinician and the patient, which will ensure achievement of the best possible outcome for the peanut-allergic child. This is a multistep process that evaluates the benefits and risks of therapy or no therapy, as well as patient and family preferences and we review it in detail in this manuscript with the aim to provide clinicians with a practical approach.

ACS Style

Aikaterini Anagnostou. A Practical, Stepwise Approach to Peanut Oral Immunotherapy in Clinical Practice: Benefits and Risks. Journal of Asthma and Allergy 2021, ume 14, 277 -285.

AMA Style

Aikaterini Anagnostou. A Practical, Stepwise Approach to Peanut Oral Immunotherapy in Clinical Practice: Benefits and Risks. Journal of Asthma and Allergy. 2021; ume 14 ():277-285.

Chicago/Turabian Style

Aikaterini Anagnostou. 2021. "A Practical, Stepwise Approach to Peanut Oral Immunotherapy in Clinical Practice: Benefits and Risks." Journal of Asthma and Allergy ume 14, no. : 277-285.

Opinion or debate
Published: 24 September 2020 in Clinical & Experimental Allergy
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Food allergies are common 1,2 and as practicing physicians, we regularly see food‐allergy sufferers in our clinics. We also find them in schools and classrooms, sometimes within our close family and friends’ environment. The effect that food allergies have on the individual and their family is significant. All aspects of daily life can be affected, including physical, psychological and social interactions, ultimately impacting on quality of life 3 4 5. It is hard to imagine a world without food allergies, but many researchers are aiming for exactly this. Over the last 5‐10 years there have been tremendous progress and impressive breakthroughs in both preventative measures 6 and treatment options for patients with food allergy 7.

ACS Style

Aikaterini Anagnostou. Food immunotherapy: Choosing wisely. Clinical & Experimental Allergy 2020, 51, 9 -13.

AMA Style

Aikaterini Anagnostou. Food immunotherapy: Choosing wisely. Clinical & Experimental Allergy. 2020; 51 (1):9-13.

Chicago/Turabian Style

Aikaterini Anagnostou. 2020. "Food immunotherapy: Choosing wisely." Clinical & Experimental Allergy 51, no. 1: 9-13.

Short communication
Published: 09 June 2020 in The Journal of Allergy and Clinical Immunology: In Practice
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ACS Style

Roman Deniskin; David Fleischer; Matthew Greenhawt; Adam T. Fox; Aikaterini Anagnostou. Differences in the evaluation of skin prick testing results for food allergy diagnosis between US and UK physicians. The Journal of Allergy and Clinical Immunology: In Practice 2020, 8, 3237 -3239.

AMA Style

Roman Deniskin, David Fleischer, Matthew Greenhawt, Adam T. Fox, Aikaterini Anagnostou. Differences in the evaluation of skin prick testing results for food allergy diagnosis between US and UK physicians. The Journal of Allergy and Clinical Immunology: In Practice. 2020; 8 (9):3237-3239.

Chicago/Turabian Style

Roman Deniskin; David Fleischer; Matthew Greenhawt; Adam T. Fox; Aikaterini Anagnostou. 2020. "Differences in the evaluation of skin prick testing results for food allergy diagnosis between US and UK physicians." The Journal of Allergy and Clinical Immunology: In Practice 8, no. 9: 3237-3239.

Review
Published: 26 May 2020 in Children
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Food allergies are common and estimated to affect 8% of children and 11% of adults in the United States. They pose a significant burden—physical, economic and social—to those affected. There is currently no available cure for food allergies. Emerging evidence suggests that the microbiome contributes to the development and manifestations of atopic disease. According to the hygiene hypothesis, children growing up with older siblings have a lower incidence of allergic disease compared with children from smaller families, due to their early exposure to microbes in the home. Research has also demonstrated that certain environmental exposures, such as a farming environment, during early life are associated with a diverse bacterial experience and reduced risk of allergic sensitization. Dysregulation in the homeostatic interaction between the host and the microbiome or gut dysbiosis appears to precede the development of food allergy, and the timing of such dysbiosis is critical. The microbiome affects food tolerance via the secretion of microbial metabolites (e.g., short chain fatty acids) and the expression of microbial cellular components. Understanding the biology of the microbiome and how it interacts with the host to maintain gut homeostasis is helpful in developing smarter therapeutic approaches. There are ongoing trials evaluating the benefits of probiotics and prebiotics, for the prevention and treatment of atopic diseases to correct the dysbiosis. However, the routine use of probiotics as an intervention for preventing allergic disease is not currently recommended. A new approach in microbial intervention is to attempt a more general modification of the gut microbiome, such as with fecal microbiota transplantation. Developing targeted bacterial therapies for food allergy may be promising for both the treatment and prevention of food allergy. Similarly, fecal microbiota transplantation is being explored as a potentially beneficial interventional approach. Overall, targeted bacterial therapies for food allergy may be promising for both the treatment and prevention of food allergy.

ACS Style

Christina L. Nance; Roman Deniskin; Veronica C. Diaz; Misu Paul; Sara Anvari; Aikaterini Anagnostou. The Role of the Microbiome in Food Allergy: A Review. Children 2020, 7, 50 .

AMA Style

Christina L. Nance, Roman Deniskin, Veronica C. Diaz, Misu Paul, Sara Anvari, Aikaterini Anagnostou. The Role of the Microbiome in Food Allergy: A Review. Children. 2020; 7 (6):50.

Chicago/Turabian Style

Christina L. Nance; Roman Deniskin; Veronica C. Diaz; Misu Paul; Sara Anvari; Aikaterini Anagnostou. 2020. "The Role of the Microbiome in Food Allergy: A Review." Children 7, no. 6: 50.

Journal article
Published: 01 May 2020 in Annals of Allergy, Asthma & Immunology
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ACS Style

Aikaterini Anagnostou. CON: Skin testing with fresh foods. Annals of Allergy, Asthma & Immunology 2020, 124, 443 -444.

AMA Style

Aikaterini Anagnostou. CON: Skin testing with fresh foods. Annals of Allergy, Asthma & Immunology. 2020; 124 (5):443-444.

Chicago/Turabian Style

Aikaterini Anagnostou. 2020. "CON: Skin testing with fresh foods." Annals of Allergy, Asthma & Immunology 124, no. 5: 443-444.

Journal article
Published: 08 April 2020 in Annals of Allergy, Asthma & Immunology
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Peanut Oral Immunotherapy (POIT) is a novel and active form of treatment with multiple research studies supporting its efficacy and safety, but there are limited data available on patients’ quality of life changes following successful desensitization. FDA recently approved the first drug for POIT commercial use. The aim of our study was to evaluate quality of life of patients with peanut allergy receiving POIT in a real-world academic setting. Twenty-one patients 4-17 years old with a physician-established diagnosis of peanut allergy were offered peanut oral immunotherapy. Quality of life scores were assessed with the use of a validated Food Allergy Quality of Life Questionnaire. Changes in quality of life scores were measured for each patient before and after POIT. The Wilcoxon signed-rank test was used to compare the distributions of scores before and after therapy. We noted a statistically significant drop (reflecting improvement in quality of life) in the overall Food Allergy Quality of life score (median 3.70 vs. 2.97, p=0.049) between baseline and successful desensitization to 300mg peanut protein. Additionally, the Social and Dietary Limitations subscale score (median 4.33 vs. 2.89, p=0.022) and the Food Allergy Independent Measure score (median 3.17 vs. 2.22, p=0.001) also improved significantly after therapy. We report a significant improvement in the overall quality of life before and after peanut oral immunotherapy treatment, with fewer concerns about accidental exposures and severity of allergic reactions, and fewer limitations in dietary choices and social interactions.

ACS Style

Andrea C. Blackman; Kristen A. Staggers; Lauren Kronisch; Carla M. Davis; Aikaterini Anagnostou. Quality of life improves significantly after real-world oral immunotherapy for children with peanut allergy. Annals of Allergy, Asthma & Immunology 2020, 125, 196 -201.e1.

AMA Style

Andrea C. Blackman, Kristen A. Staggers, Lauren Kronisch, Carla M. Davis, Aikaterini Anagnostou. Quality of life improves significantly after real-world oral immunotherapy for children with peanut allergy. Annals of Allergy, Asthma & Immunology. 2020; 125 (2):196-201.e1.

Chicago/Turabian Style

Andrea C. Blackman; Kristen A. Staggers; Lauren Kronisch; Carla M. Davis; Aikaterini Anagnostou. 2020. "Quality of life improves significantly after real-world oral immunotherapy for children with peanut allergy." Annals of Allergy, Asthma & Immunology 125, no. 2: 196-201.e1.

Letter to the editor
Published: 11 February 2020 in Pediatric Allergy and Immunology
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Peanut allergy rates have nearly tripled in the last decade. Initial guidelines, promoting avoidance of allergenic foods in infants had no effect on the rising prevalence of food allergies and the recommendations were reversed based on new evidence

ACS Style

Mansi James; Sara Anvari; Aikaterini Anagnostou. Development of peanut allergy despite early introduction: A real‐world case series in the United States. Pediatric Allergy and Immunology 2020, 31, 589 -592.

AMA Style

Mansi James, Sara Anvari, Aikaterini Anagnostou. Development of peanut allergy despite early introduction: A real‐world case series in the United States. Pediatric Allergy and Immunology. 2020; 31 (5):589-592.

Chicago/Turabian Style

Mansi James; Sara Anvari; Aikaterini Anagnostou. 2020. "Development of peanut allergy despite early introduction: A real‐world case series in the United States." Pediatric Allergy and Immunology 31, no. 5: 589-592.

Journal article
Published: 10 January 2020 in Annals of Allergy, Asthma & Immunology
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Food allergies are becoming a global concern and pose a significant burden on allergic children and their family, with reported physical and emotional effects. To investigate the effect of food allergy on patients′ quality of life (QoL), to identify any characteristics associated with worse QoL, and to directly compare the effect of food allergies on the QoL of adolescents vs younger children. Children 0 to 17 years old with a physician-confirmed food allergy diagnosis were invited to participate by completing the validated Food Allergy Quality of Life Questionnaire (FAQLQ). The FAQLQ form for children 10 to 12 years old was completed by the parent (proxy report), whereas the FAQLQ form for adolescents was completed by the adolescent (self-report). Scores were compared using the Wilcoxon rank sum test. Independent median regressions were used to test association between potential risk factors and QoL outcomes. In our cohort, the median FAQLQ score was significantly higher (reflecting lower QoL) in adolescents compared with children (4.7 vs 3.5, P = .007). The median social and dietary limitations score (5.2 vs 4, P = .002) and the median emotional impact score (3.8 vs 3.1, P = .02) were also higher in adolescents. Limitations in family activities because of food allergy had a negative effect on QoL. Food allergic adolescents are affected more than younger children (based on parental report) in terms of QoL, with a direct reflection on all areas of their daily life (emotional, dietary, and social). In addition, limitations in family activities because of the child′s food allergy significantly worsen the QoL and well being of all family members.

ACS Style

Jennifer Miller; Andrea C. Blackman; Helen T. Wang; Sara Anvari; Michelle Joseph; Carla M. Davis; Kristen A. Staggers; Aikaterini Anagnostou. Quality of life in food allergic children. Annals of Allergy, Asthma & Immunology 2020, 124, 379 -384.

AMA Style

Jennifer Miller, Andrea C. Blackman, Helen T. Wang, Sara Anvari, Michelle Joseph, Carla M. Davis, Kristen A. Staggers, Aikaterini Anagnostou. Quality of life in food allergic children. Annals of Allergy, Asthma & Immunology. 2020; 124 (4):379-384.

Chicago/Turabian Style

Jennifer Miller; Andrea C. Blackman; Helen T. Wang; Sara Anvari; Michelle Joseph; Carla M. Davis; Kristen A. Staggers; Aikaterini Anagnostou. 2020. "Quality of life in food allergic children." Annals of Allergy, Asthma & Immunology 124, no. 4: 379-384.

Journal article
Published: 01 January 2020 in The Journal of Allergy and Clinical Immunology: In Practice
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Shared decision making was first highlighted in a report by the Institute of Medicine in 2001. The primary aim of this initiative was to improve the quality of care provided to patients in the United States by creating a health care system that is safe, effective, efficient, and equitable. Currently, medical decision making is based on a patient-centered approach, with the individual's preferences, needs, and values guiding optimal care. Patients are frequently faced with various treatment choices with no absolute guarantee of any desired outcome and no clear indication of the "best or least worse" option. In fact, in healthcare, each of these options usually has potential trade-offs and outcomes. The process of how to choose a particular option becomes a discussion where the clinician and the patient have to jointly review the medical evidence, but also the patient's openness and preference for balancing particular attributes of the treatment (both positive and negative). Shared decision making is important for chronic diseases that require long-term management, such as most allergic conditions, including food allergies. The landscape of food allergies has changed considerably in recent years with multiple and significant scientific advances in both diagnostics and treatment, providing an ideal field for the use of shared decision making. For the purposes of this review, we will discuss different areas of food allergy management within a single complex case, focusing on the role of shared decision making.

ACS Style

Aikaterini Anagnostou; Jonathan O’B. Hourihane; Matthew Greenhawt. The Role of Shared Decision Making in Pediatric Food Allergy Management. The Journal of Allergy and Clinical Immunology: In Practice 2020, 8, 46 -51.

AMA Style

Aikaterini Anagnostou, Jonathan O’B. Hourihane, Matthew Greenhawt. The Role of Shared Decision Making in Pediatric Food Allergy Management. The Journal of Allergy and Clinical Immunology: In Practice. 2020; 8 (1):46-51.

Chicago/Turabian Style

Aikaterini Anagnostou; Jonathan O’B. Hourihane; Matthew Greenhawt. 2020. "The Role of Shared Decision Making in Pediatric Food Allergy Management." The Journal of Allergy and Clinical Immunology: In Practice 8, no. 1: 46-51.

Letter to the editor
Published: 25 November 2019 in Pediatric Allergy and Immunology
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Eosinophilic Esophagitis (EoE) is an immune‐mediated inflammatory condition characterized clinically by esophageal dysfunction and evidence of ≥15 eosinophils per high power field on esophageal biopsy.1 EoE is reportedly triggered by food and/or environmental allergens. Treatments include topical corticosteroids, proton‐pump inhibitors, or dietary avoidance measures. Currently, noninvasive tests such as skin prick test (SPT), atopy patch test (APT), and specific serum IgE (sIgE) are utilized by clinicians to identify potential offending allergens in their EoE patients.

ACS Style

Jessica Lee; Christopher Frey; Jennifer Miller; Charles Minard; Munazza Noor; Aikaterini Anagnostou; Anthony Olive; Carla M. Davis; Sara Anvari. Skin testing with different food formulations in pediatric patients with eosinophilic esophagitis. Pediatric Allergy and Immunology 2019, 31, 329 -332.

AMA Style

Jessica Lee, Christopher Frey, Jennifer Miller, Charles Minard, Munazza Noor, Aikaterini Anagnostou, Anthony Olive, Carla M. Davis, Sara Anvari. Skin testing with different food formulations in pediatric patients with eosinophilic esophagitis. Pediatric Allergy and Immunology. 2019; 31 (3):329-332.

Chicago/Turabian Style

Jessica Lee; Christopher Frey; Jennifer Miller; Charles Minard; Munazza Noor; Aikaterini Anagnostou; Anthony Olive; Carla M. Davis; Sara Anvari. 2019. "Skin testing with different food formulations in pediatric patients with eosinophilic esophagitis." Pediatric Allergy and Immunology 31, no. 3: 329-332.

Journal article
Published: 01 June 2019 in Annals of Allergy, Asthma & Immunology
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ACS Style

Aikaterini Anagnostou. Component resolved diagnostic testing adds clinical utility over existing testing for food allergy-PRO. Annals of Allergy, Asthma & Immunology 2019, 122, 576 -579.

AMA Style

Aikaterini Anagnostou. Component resolved diagnostic testing adds clinical utility over existing testing for food allergy-PRO. Annals of Allergy, Asthma & Immunology. 2019; 122 (6):576-579.

Chicago/Turabian Style

Aikaterini Anagnostou. 2019. "Component resolved diagnostic testing adds clinical utility over existing testing for food allergy-PRO." Annals of Allergy, Asthma & Immunology 122, no. 6: 576-579.

Journal article
Published: 08 February 2019 in Annals of Allergy, Asthma & Immunology
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Food protein-induced enterocolitis syndrome (FPIES) is a rare non-IgE mediated gastrointestinal food-induced allergic disorder occurring predominantly in infants and young children. Common food triggers and the natural history of FPIES vary according to geographic location. It is a serious condition that is still under-recognized, resulting in a delay in diagnosis and appropriate management. FPIES is characterized by delayed onset of repetitive vomiting occurring approximately 1 to 4 hours after food ingestion.

ACS Style

Andrea C. Blackman; Sara Anvari; Carla M. Davis; Aikaterini Anagnostou. Emerging triggers of food protein–induced enterocolitis syndrome. Annals of Allergy, Asthma & Immunology 2019, 122, 407 -411.

AMA Style

Andrea C. Blackman, Sara Anvari, Carla M. Davis, Aikaterini Anagnostou. Emerging triggers of food protein–induced enterocolitis syndrome. Annals of Allergy, Asthma & Immunology. 2019; 122 (4):407-411.

Chicago/Turabian Style

Andrea C. Blackman; Sara Anvari; Carla M. Davis; Aikaterini Anagnostou. 2019. "Emerging triggers of food protein–induced enterocolitis syndrome." Annals of Allergy, Asthma & Immunology 122, no. 4: 407-411.

Review
Published: 05 February 2019 in Children
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The prevalence of allergic disorders has been increasing worldwide and significantly impacts the quality of life of the atopic individual. There has been an increased interest in the role of probiotics for the prevention and treatment of allergic disorders, given the recent evidence that atopy risk may be associated with a dysbiosis of the gut microbiome. Research in this area is ongoing with some studies showing possible benefits of probiotics, with seemingly little to no risk. While these studies suggest that there may be a promise in probiotic use for the prevention or treatment of allergy, further evidence is needed to determine its efficacy, optimal dosing, and strains needed for treatment. In this review, we discuss recently published studies examining the benefits, risks, and role of probiotics in preventing atopic dermatitis, asthma, allergic rhinitis, and food allergy.

ACS Style

Helen Wang; Sara Anvari; Katherine Anagnostou. The Role of Probiotics in Preventing Allergic Disease. Children 2019, 6, 24 .

AMA Style

Helen Wang, Sara Anvari, Katherine Anagnostou. The Role of Probiotics in Preventing Allergic Disease. Children. 2019; 6 (2):24.

Chicago/Turabian Style

Helen Wang; Sara Anvari; Katherine Anagnostou. 2019. "The Role of Probiotics in Preventing Allergic Disease." Children 6, no. 2: 24.

Research article
Published: 01 January 2019 in Therapeutic Advances in Vaccines and Immunotherapy
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Background: Peanut allergy has become an important public health issue. It can be the cause of severe reactions and also the trigger of significant anxiety for the allergic individual, especially with regards to the risk of unintentional accidental exposures. Peanut oral immunotherapy (POIT) is a newly developed treatment approach that has been shown to be highly effective in multiple research studies and has been associated with an acceptable safety profile. This treatment modality is likely to become more mainstream in the next few years with new commercial entities pursuing United States Food and Drug Administration approval for relevant products and multiple providers offering various forms of immunotherapy in their practices. Methods: The aim of our study was to obtain an accurate assessment of goals of treatment as well as concerns and barriers from families considering POIT in either the research or clinical setting. A single clinician allergist met with all the families and conducted semi-structured interviews on POIT. Families were provided with standardized written information on POIT prior to the consultation, which was used as a formalized instrument to communicate treatment protocols. Conversations were not recorded, but collected information was scribed by a second clinician who did not actively participate in the consultation. Scribed information was coded by the investigators. Thematic analysis identified common topics emerging from the discussions. Results: We report on the results of 92 consecutive family consultations on POIT conducted over a period of 1 year. Approximately 50% of the families had already researched POIT online, with 25% of families reported being part of Facebook parent groups. Groups identified the following areas as the most important considerations: efficacy, practical information, safety, benefits and goals, eligibility criteria and support in making the right decision. For all families pursuing POIT for their child, the initial goal was achieving protection from accidental exposure and cross-contamination and for approximately one-quarter, consumption of high peanut doses was the ultimate goal. Conclusion: Our research adds to the limited available data in this area and provides information that may be used as an initial platform for clinical consultations and shared decision-making in POIT. Obtaining a better understanding of patients’ expectations and concerns will hopefully facilitate this process, enabling more fruitful and engaging interactions between families and healthcare providers in the field of food allergy.

ACS Style

Andrea C. Blackman; Aikaterini Anagnostou. Identification of goals and barriers to treatment from 92 consecutive consultations with families considering peanut oral immunotherapy. Therapeutic Advances in Vaccines and Immunotherapy 2019, 7, 1 .

AMA Style

Andrea C. Blackman, Aikaterini Anagnostou. Identification of goals and barriers to treatment from 92 consecutive consultations with families considering peanut oral immunotherapy. Therapeutic Advances in Vaccines and Immunotherapy. 2019; 7 ():1.

Chicago/Turabian Style

Andrea C. Blackman; Aikaterini Anagnostou. 2019. "Identification of goals and barriers to treatment from 92 consecutive consultations with families considering peanut oral immunotherapy." Therapeutic Advances in Vaccines and Immunotherapy 7, no. : 1.

Journal article
Published: 01 January 2019 in Annals of Allergy, Asthma & Immunology
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ACS Style

Theresa A. Bingemann; Carah B. Santos; Anne F. Russell; Aikaterini Anagnostou. Lupin. Annals of Allergy, Asthma & Immunology 2019, 122, 8 -10.

AMA Style

Theresa A. Bingemann, Carah B. Santos, Anne F. Russell, Aikaterini Anagnostou. Lupin. Annals of Allergy, Asthma & Immunology. 2019; 122 (1):8-10.

Chicago/Turabian Style

Theresa A. Bingemann; Carah B. Santos; Anne F. Russell; Aikaterini Anagnostou. 2019. "Lupin." Annals of Allergy, Asthma & Immunology 122, no. 1: 8-10.

Letter to the editor
Published: 27 December 2018 in Pediatric Allergy and Immunology
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Peanut allergy is increasing in prevalence in the US according to reports [1] and has become a global concern. Sensitization to tree nuts is common with reported rates of up to 86% for multi‐nut sensitization with increasing age [2] [3]. In addition, peanut allergy has been associated with an increased risk of sesame sensitization and allergy [4]. Patients’ attitudes towards tree nut and sesame consumption can be variable following a diagnosis of peanut allergy and have not previously been examined. This article is protected by copyright. All rights reserved.

ACS Style

Aikaterini Anagnostou. Insights into tree nut and sesame consumption from a cohort of 80 peanut‐allergic children. Pediatric Allergy and Immunology 2018, 30, 389 -392.

AMA Style

Aikaterini Anagnostou. Insights into tree nut and sesame consumption from a cohort of 80 peanut‐allergic children. Pediatric Allergy and Immunology. 2018; 30 (3):389-392.

Chicago/Turabian Style

Aikaterini Anagnostou. 2018. "Insights into tree nut and sesame consumption from a cohort of 80 peanut‐allergic children." Pediatric Allergy and Immunology 30, no. 3: 389-392.

Short communication
Published: 21 December 2018 in The Journal of Allergy and Clinical Immunology: In Practice
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ACS Style

Sara Anvari; Andrea C. Blackman; Aikaterini Anagnostou. Insights from 275 cases of childhood anaphylaxis in the United States. The Journal of Allergy and Clinical Immunology: In Practice 2018, 7, 1696 -1699.e2.

AMA Style

Sara Anvari, Andrea C. Blackman, Aikaterini Anagnostou. Insights from 275 cases of childhood anaphylaxis in the United States. The Journal of Allergy and Clinical Immunology: In Practice. 2018; 7 (5):1696-1699.e2.

Chicago/Turabian Style

Sara Anvari; Andrea C. Blackman; Aikaterini Anagnostou. 2018. "Insights from 275 cases of childhood anaphylaxis in the United States." The Journal of Allergy and Clinical Immunology: In Practice 7, no. 5: 1696-1699.e2.