Advances in synthetic biology and nanotechnology have contributed to the design of tools that can be used to control, reuse, modify, and re-engineer cells' structure, as well as enabling engineers to effectively use biological cells as programmable substrates to realize Bio-NanoThings (biological embedded computing devices). Bio-NanoThings are generally tiny, non-intrusive, and concealable devices that can be used for in-vivo applications such as intra-body sensing and actuation networks, where the use of artificial devices can be detrimental. Such (nano-scale) devices can be used in various healthcare settings such as continuous health monitoring, targeted drug delivery, and nano-surgeries. These services can also be grouped to form a collaborative network (i.e., nanonetwork), whose performance can potentially be improved when connected to higher bandwidth external networks such as the Internet, say via 5G. However, to realize the IoBNT paradigm, it is also important to seamlessly connect the biological environment with the technological landscape by having a dynamic interface design to convert biochemical signals from the human body into an equivalent electromagnetic signal (and vice versa). This, unfortunately, risks the exposure of internal biological mechanisms to cyber-based sensing and medical actuation, with potential security and privacy implications. This paper comprehensively reviews bio-cyber interface for IoBNT architecture, focusing on bio-cyber interfacing options for IoBNT like biologically inspired bio-electronic devices, RFID enabled implantable chips, and electronic tattoos. This study also identifies known and potential security and privacy vulnerabilities and mitigation strategies for consideration in future IoBNT designs and implementations.

The Internet of bio-nano things (IoBNT) is an emerging paradigm employing nanoscale (~1–100 nm) biological transceivers to collect in vivo signaling information from the human body and communicate it to healthcare providers over the Internet. Bio-nano-things (BNT) offer external actuation of in-body molecular communication (MC) for targeted drug delivery to otherwise inaccessible parts of the human tissue. BNTs are inter-connected using chemical diffusion channels, forming an in vivo bio-nano network, connected to an external ex vivo environment such as the Internet using bio-cyber interfaces. Bio-luminescent bio-cyber interfacing (BBI) has proven to be promising in realizing IoBNT systems due to their non-obtrusive and low-cost implementation. BBI security, however, is a key concern during practical implementation since Internet connectivity exposes the interfaces to external threat vectors, and accurate classification of anomalous BBI traffic patterns is required to offer mitigation. However, parameter complexity and underlying intricate correlations among BBI traffic characteristics limit the use of existing machine-learning (ML) based anomaly detection methods typically requiring hand-crafted feature designing. To this end, the present work investigates the employment of deep learning (DL) algorithms allowing dynamic and scalable feature engineering to discriminate between normal and anomalous BBI traffic. During extensive validation using singular and multi-dimensional models on the generated dataset, our hybrid convolutional and recurrent ensemble (CNN + LSTM) reported an accuracy of approximately ~93.51% over other deep and shallow structures. Furthermore, employing a hybrid DL network allowed automated extraction of normal as well as temporal features in BBI data, eliminating manual selection and crafting of input features for accurate prediction. Finally, we recommend deployment primitives of the extracted optimal classifier in conventional intrusion detection systems as well as evolving non-Von Neumann architectures for real-time anomaly detection.

This systematic literature review uses the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) methodology to assess progress in blockchain-based Federated learning (FL) and Machine Learning (ML) for detecting financial fraud over the last five years (2020–2025). An initial pool of 29,274 records identified across IEEE Xplore, ACM Digital Library, and ScienceDirect yielded 1585 peer-reviewed studies that met the inclusion criteria. Both qualitative and quantitative approaches were used. The examined papers were classified according to algorithm type, fraud types, and evaluation measures. Credit card fraud and cryptocurrency fraud dominated the literature, with supervised learning (e.g., XGBoost, 95% accuracy) and federated learning (e.g., FedAvg, 91% accuracy) emerging as dominant methodologies. Centralized ML outperforms FL in latency but poses privacy risks. FL–blockchain hybrids reduce false positives. While precision, recall, and F1-score are commonly used, few studies use cost-sensitive criteria. Future research should prioritize adaptive FL aggregation, privacy-preserving ML, and cross-industry collaboration.