Background: Some studies have investigated the prognostic value exhibited by the Prognostic Nutritional Index (PNI) in patients suffering diffuse large B-cell lymphoma (DLBCL), but varying results were obtained. In order to determine the specific prognostic value more accurately, a meta-analysis was conducted in this study. Methods: Literatures were searched from the China National Knowledge Infrastructure (CNKI), Wanfang, PubMed, Embase, the Cochrane Library, and Web of Science. Pooled hazard ratio (HR) and the 95% confidence interval (CI) were calculated to assess the association between PNI and the overall survival (OS) and the progression-free survival (PFS) of patients with DLBCL. Results: Based on seven studies with a total number of 1311 patients, our meta-analysis revealed that low PNI may meant poor OS (HR = 2.14, 95% CI 1.66–2.75, p < 0.001) and poor PFS (HR = 1.75, 95% CI 1.36–2.25, p = 0.438). Subgroup analysis showed that, in Asians, low PNI was correlated to poor OS (pooled HR = 2.06 95% CI 1.59–2.66) and poor PFS (pooled HR = 1.66, 95% CI 1.28–2.15). Similar results were obtained from one European study, which is the only study performed outside of Asia from our literature search. Conclusion: For patients with DLBCL, low PNI may be interpreted as adverse prognosis. More data from European patients are required in this study to avoid analysis bias.

Background: Studies have shown the value of subtypes and distribution of gastric intestinal metaplasia (GIM) for prediction of gastric cancer. We aim to combine GIM subtypes and distribution to form a new scoring system for GIM.Methods: This was a cross-sectional study. No GIM, type I, II, and III GIM of gastric antrum and corpus scored 0–3 points respectively. Then the severity of the whole stomach was calculated in two ways: 1. The gastric antrum and corpus scores were added together, with a score ranging from 0 to 6, which named “Subtype Distribution Score of Gastric Intestinal Metaplasia (SDSGIM)”. 2. Direct classification according to a table corresponding to that of OLGIM. We compared the SDSGIM among benign lesions, dysplasia, and cancer and drew receiver operating characteristic (ROC) curve to determine the optimal cut-off value. According to the cut-off value and the classification from the table, the predictive ability of these two methods were calculated.Results: 227 patients were included. For SDSGIM, benign lesion group was significantly different from dysplasia or cancer group. Area under curve of ROC curve was 0.889 ± 0.023. The optimal cut-off value was 3. The sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of SDSGIM for malignancy were 89.5%, 78.0%, 74.6%, 91.2% and 82.8%. And those for the second classification method were 84.2%, 82.6%, 77.7%, 87.9%, and 83.3% respectively.Conclusions: This study firstly combined GIM subtypes with its distribution forming a novel scoring system, which showed high prediction accuracy for malignant lesions.

Objective: To conduct a systematic review and meta-analysis on the prediction of severity of gastric intestinal metaplasia (GIM) in localized and entire gastric mucosa using endoscopy. Methods: The...

Background Although the problem of whether to perform a biopsy before endoscopic treatment for colorectal laterally spreading tumor (LST) troubles clinicians, about 50 % of lesions still undergo a preceding biopsy. We aimed to explore factors affecting the non-lifting sign in LST and examine the influence of “biopsy-related factors”, such as the number of biopsy specimens and the interval after biopsy on non-lifting sign in cases with a history of biopsy. Methods Clinical data of 159 LSTs regarding age, gender, history of biopsy, tumor location, tumor size, the depth of submucosal invasion, tumor configuration, histologic type, location with respect to the fold, and result of non-lifting sign testing were investigated retrospectively. For patients with a history of biopsy, the period after biopsy and the number of biopsy specimens also were analyzed. Results Among 159 cases of LST, 112 were positive and 47 were negative for lifting signs. Biopsy history (p = 0.008), tumor size (p = 0.010), and location with respect to the fold (p = 0.022) were identified as factors affecting the non-lifting sign in multivariate analyses. In 75 LST cases with a history of biopsy, only the number of biopsies (p = 0.003) was identified as a factor affecting the non-lifting sign in multivariate analyses. Conclusions For LST, lesions with larger size, being across the fold, and biopsy history were predictive factors for non-lifting signs. Reducing the number of biopsies would reduce the occurrence of non-lifting signs when biopsy is necessary. The impact of the interval after the biopsy on the non-lifting sign will require further study. Hintergrund Obwohl eine Biopsie vor der endoskopischen Behandlung eines kolorektalen Laterally-spreading-Tumors (LST) bei Klinikern durchaus umstritten ist, wird immer noch bei etwa 50 % der Läsionen eine Biopsie durchgeführt. Unser Ziel war es, Faktoren für das non-lifting sign bei LSTs zu bestimmen und den Einfluss von „biopsiebezogenen Faktoren“ wie Zahl der Biopsieproben und das Intervall nach der Biopsie auf das non-lifting sign in Fällen mit einer zuvor durchgeführten Biopsie weiter zu untersuchen. Methoden Die klinischen Daten von 159 LSTs wurden in Bezug auf Alter, Geschlecht, Biopsieanamnese, Tumorlokalisation, Tumorgröße, Tiefe der submukosalen Invasion, Tumorkonfiguration, Histologie, Lokalisation in Bezug auf die Falte und Ergebnis der Untersuchung auf non-lifting sign retrospektiv untersucht. Bei Patienten mit einer Biopsie in der Anamnese wurden zusätzlich die Zeit nach der Biopsie und die Zahl der Biopsieproben analysiert. Ergebnisse Von den 159 LST Fällen waren 112 positiv und 47 Fälle negativ in Bezug auf das lifting sign. Eine zuvor durchgeführte Biopsie (P = 0,008), die Tumorgröße (P = 0,010) und die Lage in Bezug auf die Falte (P = 0,022) wurden in multivariaten Analysen als Faktoren identifiziert, die das non-lifting sign beeinflussen. In 75 LST-Fällen mit einer zuvor durchgeführten Biopsie wurde allein die Zahl der Biopsien (P = 0,003) als ein Faktor identifiziert, der das non-lifting sign in multivariaten Analysen beeinflusst. Schlussfolgerungen Bei LSTs waren größere Läsionen, die quer zur Falte liegen, und eine zuvor durchgeführte Biopsie prädiktive Faktoren für das non-lifting sign. Wenn eine Biopsie notwendig ist, würde eine Verringerung der Zahl der Biopsien das Auftreten des non-lifting signs verringern. Der Einfluss des Intervalls nach der Biopsie auf das non-lifting sign müsste weiter untersucht werden. ^# Yang Liu and Ning Wie are co-first authors. Received: 22 May 2020 Accepted: 09 November 2020 Publication Date: 12 April 2021 (online) © 2020. Thieme. All rights reserved. Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, Germany

Sarcopenia has been shown to be associated with the prognosis of patients with liver cirrhosis, hepatocellular carcinoma, liver failure. However, the impac