Endoscopic submucosal dissection (ESD) is a minimal invasive technology and could allow “en bloc” resection for superficial gastric tumors. The aim of this study is to evaluate the safety and feasibility of ESD for gastric ectopic pancreas (EP). A total of 93 patients diagnosed with ectopic pancreas who underwent ESD between January 2011 and June 2017 were enrolled. The demographic, clinical, and endoscopic data were collected and analyzed. The average maximal diameter of lesions was 1.01 (range 0.4–3.0) cm with mean age of patients which was 39.75 (range 15–66) years. Overall, all of procedures en bloc was successful. The median operative time was 76.87 (range 30–160) min. A total of 12 patients experienced complications. In seven patients, bleeding occurred during the operation and was treated using hot biopsy forceps or metal clip. Five cases suffered from pneumoperitoneum which was managed well. The mean length of postoperative hospital stay was 5.7 (range 2–17) days. There was no relapse in any cases during the follow-up. ESD appears to be a safe and feasible approach for curative treatment in gastric ectopic pancreas. Larger studies are needed to identify the role and the outcomes of ESD in another center.

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