Additive manufacturing techniques are being used in the medical field. Orthopedic hip prostheses and denture bases are designed and fabricated based on the patient’s computer-aided design (CAD) data. We attempted to incorporate this technique into dental implant bone augmentation. Surgical simulation was performed using patient data. Fourteen patients underwent bone augmentation using a selective laser melting (SLM) titanium mesh plate. The results showed no evidence of infection in any of the 14 patients. In 12 patients, only one fixation screw was used, and good results were obtained. The SLM titanium mesh plate was good adaptation in all cases, with bone occupancy greater than 90%. The average bone resorption of the marginal alveolar bone from the time of dental implant placement to the time of the superstructure placement was 0.69 ± 0.25 mm. Implant superstructures were placed in all cases, and bone augmentation with SLM titanium mesh plates was considered a useful technique.

Titanium implants are subjected to various surface treatments to improve their in vivo function. In this study, we evaluated the usefulness of titanium implants treated with acid, NaOH, CaCl₂, heat, and ICl₃ (Ac-NaCaThIo) in terms of in vivo bone-bonding strength, bone formation, and histological anti-inflammatory properties. Iodine-loaded experimental dental implants and commercial control dental implants were placed in rabbit femurs, and bone-bonding strength was evaluated by measuring the implant stability quotient (ISQ), bone formation using tissue specimens, and the effect of iodine using thyroid-stimulating hormone (TSH) levels. Iodine-loaded titanium plates and untreated titanium plates were placed on rat skulls and inoculated with Streptococcus mitis (S. mitis) solution to evaluate anti-inflammatory properties. Consequently, the experimental implants did not demonstrate non-inferiority in bone-bonding strength (ISQ) compared with the controls; however, histological specimens revealed dense bone contact and favorable bone formation. TSH levels showed no differences at 13 weeks, indicating no long-term adverse effects of iodine. The experimental tissue specimens of the soft tissue had fewer inflammatory cells than the control at 2 weeks after placement, demonstrating an anti-inflammatory effect. These results suggest that, although non-inferiority in ISQ was not demonstrated, Ac-NaCaThIo-treated implants showed favorable bone formation, dense bone contact, anti-inflammatory properties, and biosafety, indicating potential for future applications.