This study reports the trace metal concentrations in PM₁₀ collected in two urban sites of Campeche, Mexico (the INAH site, located in the downtown, and the TNL site, located in the Tecnologico Nacional de Mexico campus Lerma). Trace metals (Cd, Co, Cu, Fe, Mn, and Zn) were determined by flame atomic absorption spectroscopy, with Fe and Mn being the most dominant species. Cd and Co showed high values of enrichment factors, indicating that they were highly enriched by anthropogenic sources. A health risk assessment was carried out according to the IRIS-EPA methodology considering both carcinogenic and non-carcinogenic effects and different age and gender population groups. The TNL site showed cancer risk coefficients that exceed the maximum limits established by the EPA and the WHO (1 × 10⁻⁶ and 1 × 10⁻⁵, respectively), being higher for Cd and Co. The non-carcinogenic risk exceeded the limits recommended by the EPA, being higher in the INAH site for cobalt (HQ = 28.92). There is a latent risk that the exposed population may develop cardiovascular and respiratory diseases due to inhalation of the metals measured in PM₁₀. It is necessary to carry out more continuous monitoring campaigns of trace metals linked to PM₁₀ in this area to enable a better understanding of the effects of these contaminants on the health of the exposed population. The results of the present work constitute the first efforts to evaluate the trace metals concentrations in PM₁₀ in urban areas of the city of Campeche, Campeche and can be used to develop programs focused on improving air quality.