Cervical cancer represents the second leading cause of death for women worldwide. The importance of the diet and its impact on specific types of neoplasia has been highlighted, focusing again interest in the analysis of dietary phytochemicals. Polyphenols have shown a wide range of cellular effects: they may prevent carcinogens from reaching the targeted sites, support detoxification of reactive molecules, improve the elimination of transformed cells, increase the immune surveillance and the most important factor is that they can influence tumor suppressors and inhibit cellular proliferation, interfering in this way with the steps of carcinogenesis. From the studies reviewed in this paper, it is clear that certain dietary polyphenols hold great potential in the prevention and therapy of cervical cancer, because they interfere in carcinogenesis (in the initiation, development and progression) by modulating the critical processes of cellular proliferation, differentiation, apoptosis, angiogenesis and metastasis. Specifically, polyphenols inhibit the proliferation of HPV cells, through induction of apoptosis, growth arrest, inhibition of DNA synthesis and modulation of signal transduction pathways. The effects of combinations of polyphenols with chemotherapy and radiotherapy used in the treatment of cervical cancer showed results in the resistance of cervical tumor cells to chemo- and radiotherapy, one of the main problems in the treatment of cervical neoplasia that can lead to failure of the treatment because of the decreased efficiency of the therapy.

Cancer represents the disease of the millennium, a major problem in public health. The proliferation of tumor cells, angiogenesis, and the relationship between the cancer cells and the components of the extracellular matrix are important in the events of carcinogenesis, and these pathways are being used as targets for new anticancer treatments. Various venoms and their toxins have shown possible anticancer effects on human cancer cell lines, providing new perspectives in drug development. In this review, we observed the effects of natural toxins from bee and snake venom and the mechanisms through which they can inhibit the growth and proliferation of cancer cells. We also researched how several types of natural molecules from venom can sensitize ovarian cancer cells to conventional chemotherapy, with many toxins being helpful for developing new anticancer drugs. This approach could improve the efficiency of standard therapies and could allow the administration of decreased doses of chemotherapy. Natural toxins from bee and snake venom could become potential candidates for the future treatment of different types of cancer. It is important to continue these studies concerning therapeutic drugs from natural resource and, more importantly, to investigate their mechanism of action on cancer cells.

Pregnancy in adolescence represents a major nutritional challenge, with competing demands between maternal development and fetal growth. Choline is the essential nutrient with a critical role for fetal brain development and exhibits distinct metabolic patterns in pregnant adolescents aged 15–19 years compared to adult pregnant women. This narrative review examines the specific impact of choline status on fetal neurodevelopment in adolescent pregnancies. A comprehensive literature review was conducted using PubMed and Web of Science databases from 2000 to 2025, focusing on choline metabolism, placental transport mechanisms, and neurodevelopmental outcomes in adolescent pregnancy. Adolescent pregnant women demonstrate reduced choline clearance (0.8 ± 0.2 vs. 1.2 ± 0.3 mL/min/kg), decreased choline kinase activity (25–30% reduction), and reduced placental transporter expression (CTL1 reduced by 15–20%) compared to adults. These metabolic differences result in maternal–fetal competition for limited choline resources, potentially compromising fetal brain development during critical neurodevelopmental windows. The consequences include increased risk of neural tube defects, altered hippocampal development, and long-term cognitive impairments in offspring. Adolescent pregnancy creates a unique biochemical environment that may predispose to choline deficiency with lasting neurodevelopmental consequences, and current supplementation guidelines do not address adolescent-specific needs, pointing out the urgent requirement for appropriate age recommendations and targeted interventions to optimize maternal and fetal outcomes in this vulnerable population.

Background: Adolescent pregnancies represent a significant global health challenge, with increased risks of maternal and neonatal complications. Traditional obstetrical risk assessment tools have limited applicability in this population due to unique physiological and anatomical characteristics. This study aimed to develop and validate novel predictive scores specifically designed for obstetrical risk stratification in adolescent pregnancies. Methods: A retrospective study was conducted over seven years (2018–2024) in Brasov County, Romania, including 1322 adolescent pregnancies (ages 12–16 years). Two novel predictive scores were developed: the Cervical Ripening Ultrasound Index (CRUI) for predicting successful vaginal delivery and labor induction, and the ADOLESRISK score for comprehensive obstetrical risk stratification. Statistical analysis included logistic regression, ROC curve analysis, and validation testing using SPSS 26.0 and R Studio version 4.3.2. Results: The CRUI score demonstrated superior predictive performance (AUC = 0.87, 95% CI: 0.84–0.90) compared to traditional Bishop score (AUC = 0.62, 95% CI: 0.58–0.66) for successful labor induction in adolescents. The ADOLESRISK score achieved 84% sensitivity and 76% specificity for predicting major obstetrical complications, significantly outperforming conventional risk assessment tools. Key risk factors incorporated included maternal age, educational level, nutritional status, and specific ultrasound parameters. Internal validation using train–test split methodology (70–30%) confirmed robust performance in the independent validation cohort (n = 397), with maintained discriminative ability (CRUI: AUC = 0.85, 95% CI: 0.80–0.90; ADOLESRISK: AUC = 0.82, 95% CI: 0.77–0.87) across different demographic subgroups. Conclusions: The CRUI and ADOLESRISK scores represent significant advances in adolescent obstetrical care, providing clinicians with tools for personalized risk assessment and management. Implementation of these scores could potentially reduce maternal complications by 25–30% and improve neonatal outcomes by 20–25%, representing a major contribution to adolescent reproductive health globally.