Stefan Ionac

Stefan Ionac


Research Focus & Metrics

Academic Career Length

4Years (2023-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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2 February 2024 in Journal of Clinical Medicine
Verified
Journal Article
Open access
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MPMircea Ionut Popitiu
Mircea Ionut Popitiu
VAVlad Adrian Alexandrescu
Vlad Adrian Alexandrescu
GCGiacomo Clerici
Giacomo Clerici
SIStefan Ionac
Stefan Ionac
GGGloria Gavrila-Ardelean
Gloria Gavrila-Ardelean
Mihai IonacMihai Ionac
Mihai Ionac
Background: Revascularization based on the angiosome concept (AC) is a controversial subject because there is currently no clear evidence of its efficacy, due to the heterogeneity of patients (multiple and diverse risk factors and comorbidities, multiple variations in the affected angiosomes). Choke vessels change the paradigm of the AC, and the presence or absence of the plantar arch directly affects the course of targeted revascularization. The aim of this study was to evaluate the effect of revascularization based on the AC in diabetic patients with chronic limb-threatening ischemia (CLTI). Methods: This retrospective analysis included 51 patients (40 men, 11 women), with a mean age of 69 years (66–72) and a total of 51 limbs, who presented with Rutherford 5–6 CLTI, before and after having undergone a drug-coated balloon angioplasty (8 patients) or plain balloon angioplasty (43). Between November 2018 and November 2019, all patients underwent below-the-knee balloon angioplasties and were followed up for an average of 12 months. The alteration of microcirculation was compared between directly and indirectly revascularized angiosomes. The study assessed clinical findings and patient outcomes, with follow-up investigations, comparing wound healing rates between the different revascularization methods. Patient records and periprocedural leg digital subtraction angiographies (DSA) were analyzed. Differences in outcomes after direct revascularization and indirect percutaneous transluminal angioplasty (PTa) were examined using Cox proportional hazards analysis, with the following endpoints: ulcer healing, limb salvage, and also amputation-free survival. Results: Direct blood flow to the angiosome supplying the ulcer area was achieved in 38 legs, in contrast to 13 legs with indirect revascularization. Among the cases, there were 39 lesions in the anterior tibial artery (ATA), 42 lesions in the posterior tibial artery (PTA), and 8 lesions in the peroneal artery (PA). According to a Cox proportional hazards analysis, having fewer than three ( 3 (HR 0.94, 95% CI 0.63–1.39, p = 0.748) were significantly associated with poor leg salvage. Additionally, direct endovascular revascularization was associated with a lower rate of major amputation compared to indirect angioplasty (HR 1.09, 95% CI 0.34–3.50, p = 0.884). Conclusions: Observing the angiosomes concept in decision-making appears to result in improved rates of arterial ulcer healing and leg salvage, particularly in targeted drug-coated balloon angioplasty for diabetic critical limb ischemia, where multiple angiosomes are typically affected.

31 August 2025 in Journal of Clinical Medicine
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Journal Article
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MBMihai Cosmin Burta
Mihai Cosmin Burta
AAAvram Adela
Avram Adela
RARadu Florian Avram
Radu Florian Avram
SRSteven Kristofor Rogers
Steven Kristofor Rogers
FBFrank L. Lee Bowling
Frank L. Lee Bowling
Mihai IonacMihai Ionac
Mihai Ionac
Introduction: The introduction of radial-firing laser fibers has minimized catheter-to-vein distance during endovenous laser ablation (EVLA) for the great saphenous vein (GSV) and anterior saphenous veins (ASVs). This study investigates flush endovenous laser ablation (fEVLA) effectiveness in addressing chronic superficial venous insufficiency (CVI). Materials and methods: This single-center retrospective study analyzed consecutive fEVLA cases with duplex ultrasound follow-up at 1, 4, and 12 weeks. The primary endpoint was clinically significant endovenous heat-induced thrombosis (classes III–IV). Results: Three hundred and twelve patients were recruited (405 affected limbs, 369 GSV, and 36 ASV). CEAP classifications were stratified as follows: C2 in 6.1%, C3 in 34.2%, C4 in 44%, C5 in 2.7%, and C6 in 12.7% of cases. Perforator ligation, phlebectomy, or foam sclerotherapy were carried out in conjunction with EVLA. fEVLA was feasible in all cases. The success rate was 96.78%, defined as EHIT classes 1 and 2, and assessed by ultrasound one week postoperatively. Clinically significant EHIT (2.5% class 3 and 0.2% class 4) was managed with 15 mg rivaroxaban twice daily for 21 days. Follow-up at 4 weeks revealed complete resolution of all EHIT 3–4 cases. No cases of pulmonary embolism or deep vein thrombosis were observed during the study or follow-up period. Conclusions: fEVLA is a safe treatment for superficial CVI across various CEAP classes, and with prompt detection, the minimal complication rate can be completely resolved.

21 December 2023 in Journal of Clinical Medicine
Verified
Journal Article
Open access
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SIStefan Ionac
Stefan Ionac
SRSteven Kristofor Rogers
Steven Kristofor Rogers
CBCosmina Ioana Bondor
Cosmina Ioana Bondor
FBFrank L. Lee Bowling
Frank L. Lee Bowling
IDIulia Iovanca Dragoi
Iulia Iovanca Dragoi
Mihai IonacMihai Ionac
Mihai Ionac
(1) Background: This retrospective Romanian study aimed to calculate the rate of, and comparison between, amputation and revascularisation for patients with either cardiovascular or diabetic comorbidities. (2) Materials: In our hospital-based database, we analysed patient-level data from a series of 61 hospitals for 2019, which covers 44.9% of the amputation patients for that year. The national database is compiled by the national houses of insurance and was used to follow amputations and revascularisations between 2016 and 2021. (3) Results: During the six-year period, the mean number of amputations and revascularisations was 72.4 per 100,000 inhabitants per year for both groups. In this period, a decline in open-surgical revascularisation was observed from 58.3% to 47.5% in all interventions but was not statistically significant (r = −0.20, p = 0.70). The mean age of patients with amputation (hospital-based database) was 67 years. Of these patients, only 5.1% underwent revascularisation in the same hospital prior to amputation. The most common comorbidities in those undergoing amputations were peripheral arterial disease (76.8%), diabetes (60.8%), and arterial hypertension (53.5%). Most amputations were undertaken by general surgeons (73.0%) and only a small number of patients were treated by vascular surgeons (17.4%). (4) Conclusions: The signal from our data indicates that Romanian patients probably have a high risk of amputation > 5 years earlier than Western European countries, such as Denmark, Finland, and Germany. The prevalence of revascularisations in Romania is 64% lower than in the Western European countries.

16 November 2025 in Annals of Vascular Surgery
Verified
Journal Article
Open access
SIStefan Ionac
Stefan Ionac
HKHagen Kerndl
Hagen Kerndl
TWTobias Dominik Warm
Tobias Dominik Warm
AHAlexander Hyhlik-Dürr
Alexander Hyhlik-Dürr
YGYvonne Gosslau
Yvonne Gosslau
To evaluate whether the sex of the operating surgeon influences postoperative outcomes after carotid endarterectomy (CEA). We hypothesized that patients treated by female surgeons have lower complication rates or mortality. A retrospective, single-center analysis was conducted of all CEA procedures performed between January 2012 and December 2023 by the Clinic of Vascular Surgery of the University Hospital Augsburg. Patient demographics, comorbidities, and operative details were collected from the German national quality assurance database. The primary outcomes included perioperative complications and 30-day mortality. Secondary outcomes included operative time and surgical technique preference. Outcomes were compared between cases performed by male and female surgeons using univariate analysis and multivariable logistic regression. A total of 1130 CEA operations met the inclusion criteria. Of these, 905 (80.1%) were performed by male surgeons and 225 (19.9%) by female surgeons. Patient characteristics were comparable between the two groups. Male surgeons more frequently used eversion endarterectomy (odds ratio for eversion by male vs. female surgeon 1.65; 95% confidence interval: 1.02-2.67; P = 0.04). The median incision-to-suture operative time was longer under female surgeons (101 min [interquartile range: 87-118] vs. 86 [70-106] min for male surgeons; P < 0.001). The rate of any perioperative complication was 4.4% for female surgeons versus 6.6% for male surgeons (P = 0.32). Thirty-day mortality was low in both groups (0.4% vs. 0.7%; P = 0.67). Surgeon sex was not associated with significant differences in perioperative complications or mortality following CEA. Female surgeons had significantly longer operative times, without negatively impacting patient outcomes. These findings support sex equity in vascular surgery.