The growing imperative for sustainable development generates research in the field and explores innovative approaches to manage vegetable crops to reduce the usage of synthetic inputs commonly associated with conventional practices as well as to promote the undertaking of organic solutions. Tomatoes are universally recognized as a highly significant and popular fruit vegetable due to their large use palette. Trials were carried out in the Gâlgău area, Transylvania, Romania. Bifactorial experiments were organized to quantify the influence of fertilization and treatments on the morpho-productive and quantitative traits of the Ruxandra tomato cultivar and on Phytophthora infestans levels of infection. The use of mixed fertilization resulted in the best performances of morphological traits (highest leaf area, highest number of leaves and fruits, highest chlorophyll content) and part of the productive traits (highest content of dry matter), and the lowest levels of infection in cv. Ruxandra, while the use of NPK soil fertilization led to the best performances in fruit weight and NUE, whatever the administered treatment. The treatment with herbal extracts showed a similar efficacy in increasing the averages of morpho-productive traits and diminishing the P. infestans level of infection compared with the conventional treatment. The treatment efficacy was mainly influenced by temperature and relative air humidity, regardless of the fertilization strategies applied.