Alice Bertoletti

Dr. Alice Bertoletti

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Research Focus & Metrics

Academic Career Length

6Years (2021-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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12 April 2021 in Animals
Verified
Journal Article
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RGRodolfo Gialletti
Rodolfo Gialletti
Sara NannaroneSara Nannarone
Sara Nannarone
MGMarco Gandini
Marco Gandini
Anna CerulloAnna Cerullo
Anna Cerullo
ABAlice Bertoletti
Alice Bertoletti
GGGessica Giusto
Gessica Giusto
Nephrosplenic space (NSS) ablation has been demonstrated to be an effective technique for prevention of left dorsal displacement of the large colon and multiple laparoscopic techniques, among which ablation with mesh or with a barbed suture, have been proposed. Our objective was to compare two laparoscopic techniques for closure of the NSS in twenty-eight horses diagnosed with nephrosplenic entrapment. Medical records of horses that had laparoscopic NSS ablation in two referral centers between 2017–2019 were retrieved. Duration of surgery, complications, and short- and long-term follow-up information were collected and compared. Costs were also calculated and compared. All horses met the inclusion criteria: 9 had NSS ablation with a mesh implant (group M), 19 with barbed suture material (group B). One horse in group B had recurrent colic after discharge. At control laparoscopy after 5 months, the NSS resulted in still not being ablated because of a failure of the suture. In group M, three horses had recurrent colic. One was successfully treated medically, one died of unknown causes and the third required a second laparoscopic suturing at 3–6 months because of failure of the mesh implant. The mean time of surgery and costs were lower in group B compared to group M. The barbed suture technique was faster, more cost-effective and had a lower complication rate than the mesh implant.

13 May 2021 in Veterinary Sciences
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Journal Article
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Leonardi LeonardoLeonardi Leonardo
Leonardi Leonardo
ABAlice Bertoletti
Alice Bertoletti
EBEnrico Bellezza
Enrico Bellezza
IPIlaria Pettinari
Ilaria Pettinari
RGRodolfo Gialletti
Rodolfo Gialletti
Teratoma is a rare germ cell testicular cancer composed of cells that are not normally present in the site where it originates. These tumors are rarely described in horses, where they may develop due to cryptorchidism. Teratomas consist of cells originating from different germinal layers, arising from germinal multi-potential cells with differentiation defects, and can simultaneously contain several tissues from two or more embryonic layers. Testicular teratomas are described in horses, cats, dogs, wild boars, bulls, and humans. In the rare descriptions found in literature of testicular teratoma in stallions, they occur frequently in cryptorchid testicles, as a consequence of congenital neoplasm. To our knowledge there is no other report of a dentigerous equine teratoma in a stallion. We describe here a successful laparoscopic removal of a testicular teratoma and its clinic-pathological features.

17 April 2025 in Microorganisms
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Journal Article
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Anna CerulloAnna Cerullo
Anna Cerullo
MNMatteo Riccardo Di Nicola
Matteo Riccardo Di Nicola
NSNicola Scilimati
Nicola Scilimati
ABAlice Bertoletti
Alice Bertoletti
GPGiuseppe Pollicino
Giuseppe Pollicino
FPFabrizio Passamonti
Fabrizio Passamonti
Bacterial contamination of the surgical site in horses is a major risk factor for the development of surgical site infections (SSIs), which increase morbidity, mortality, the hospitalisation period, antibiotic use, and management costs. While contamination is a prerequisite for infection, its progression to clinical infection depends on additional factors that compromise host defences. The present study, conducted at the Veterinary Teaching Hospital of the University of Perugia over an 11-month period, investigated bacterial contamination in 70 surgeries (53 clean and 17 clean-contaminated) at the end of the procedure. To exclude pre-existing contamination, a sterile swab was collected after surgical scrub, and only cases that entered surgery with a sterile operative field were considered. A swab, biopsy, and fine-needle aspiration from the wound margins were then performed at the end of the surgery to conduct a qualitative assessment of the bacterial contamination of the surgical sites. Risk factors for surgical field contamination were analysed separately for clean and clean-contaminated procedures. Specifically, for clean-contaminated surgeries, the presence of emergency conditions, surgery duration, and intra-operative complications were evaluated. For clean surgeries, risk factors included the type of operating room, surgical duration, tissue involved, use of local anaesthetics, and placement of surgical drapes. The results revealed bacterial contamination rates of 49.1% in clean surgeries and 41.2% in clean-contaminated surgeries. Coagulase-negative staphylococci were the most frequently isolated bacteria, followed by Burkholderia cepacia, Bacillus sp., and Stenotrophomonas maltophilia. A statistical analysis showed no significant results on the predictive factors of the contamination evaluated. However, the observed trends suggest the importance of further investigating these risk factors in a larger sample size. These results emphasise the importance of effective prophylactic measures to limit surgical site contamination. Future research will focus on optimising pre-operative and intra-operative prophylaxis strategies to reduce bacterial contamination to sub-pathogenic levels, thereby enhancing post-operative outcomes.

1 March 2024 in Journal of the American Veterinary Medical Association
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Journal Article
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KGKübra Guidoni
Kübra Guidoni
SSStefano Schiavo
Stefano Schiavo
NSNicola Scilimati
Nicola Scilimati
ABAlice Bertoletti
Alice Bertoletti
FRANCESCA BECCATIFRANCESCA BECCATI
FRANCESCA BECCATI
"Abnormal head and neck carriage following trauma in a 5-month-old Thoroughbred colt" published on 09 Nov 2023 by American Veterinary Medical Association.

17 February 2026 in Veterinary Sciences
Verified
Journal Article
Open access
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Anna CerulloAnna Cerullo
Anna Cerullo
NSNicola Scilimati
Nicola Scilimati
MNMatteo Riccardo Di Nicola
Matteo Riccardo Di Nicola
LCLuca Colla
Luca Colla
SMSusanna Mazza
Susanna Mazza
RGRodolfo Gialletti
Rodolfo Gialletti
Left dorsal displacement of the large colon (LDDLC) is a common cause of colic in horses and it is frequently associated with recurrent episodes, with significant implications for horse management, athletic performance, and owner satisfaction. Laparoscopic nephrosplenic space (NSS) ablation is a preventive surgical technique aimed at reducing recurrence in horses with a history of medically or surgically treated LDDLC. This retrospective study evaluated 48 horses that underwent laparoscopic NSS ablation in two Italian Veterinary Teaching Hospitals between 2016 and 2024. Short-term outcomes, including immediate postoperative complications and discharge status, were assessed. Long-term follow-up data were collected via owner questionnaires, focusing on survival, recurrence of colic, post-surgical complications, return to athletic or breeding activity, and owner satisfaction. Most horses were discharged without complications (91.7%), while postoperative colic occurred in 8.3%. Kaplan–Meier estimated one-year post-discharge survival was 83.3%, and 81.3% of horses were alive at last follow-up (range 0.7 months to 8.8 years). Post-discharge complications were reported in 31.2% of horses, most commonly recurrent LDDLC. Return to preoperative athletic or breeding activity was reported in 70.8% of cases, and owner satisfaction was high (83.3%). Time-to-event analysis indicated markedly reduced survival in horses requiring laparotomy during follow-up. Bayesian logistic models suggested lower mortality and fewer post-discharge complications in horses with prior colic surgery, whereas a history of recurrent colic and laparotomy during follow-up was associated with higher mortality and complications. These results indicate that laparoscopic NSS ablation is an effective and safe procedure for long-term management of horses at risk of LDDLC, allowing a high rate of survival, functional recovery, and owner satisfaction, despite the persistence of occasional colic episodes.

15 January 2024 in Animals
Verified
Journal Article
Open access
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NSNicola Scilimati
Nicola Scilimati
Anna CerulloAnna Cerullo
Anna Cerullo
Sara NannaroneSara Nannarone
Sara Nannarone
RGRodolfo Gialletti
Rodolfo Gialletti
GGGessica Giusto
Gessica Giusto
ABAlice Bertoletti
Alice Bertoletti
Small colon impaction can result in accumulation of ingesta, gas, and fluid orally to the impaction site in horses. Large colon tympany, which is caused by ingesta fermentation, can be a predisposing factor for intestinal displacement. The aim of this study is to report the history, clinical, and surgical findings of horses and ponies referred for abdominal pain not responsive to drugs where a right dorsal displacement (RDD) or large colon volvulus (LCV), together with a small colon faecalith (SCF), were diagnosed during surgery. This study included a total of five horses and five ponies. Based on clinical features, ultrasonographic examination, and rectal palpation, an initial suspected diagnosis of RDD, LCV or severe large colon and caecum distension was made in all clinical cases. Due to the lack of response to medical treatment or worsening of colic symptoms, surgery was performed in all horses: diagnosis of RDD or LCV was made and a SCF was incidentally detected in all cases. While exploratory laparotomy was carried out in all the patients for the presence of a large colon issue, it was probably subsequent to an obstruction of the small colon caused by the presence of an SCF, which is generally difficult to diagnose. This study reported the presence of SCF as a possible cause of secondary RDD or LCV in horses and ponies that, to the authors’ knowledge, has never been reported.