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Michal Ciebiera
Second Department of Obstetrics and Gynecology, Center of Postgraduate Medical Education, 80 Ceglowska St., 01-809 Warsaw, Poland

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Journal article
Published: 23 August 2021 in Biology
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Substantial progress has been made in the diagnosis, management, and treatment of breast cancer over the last decades. This has affected mortality rates but has also led to inequality in epidemiological trends between different regions of the world. We extracted death certification data for breast cancer from the World Health Organization database. We analyzed trends in breast cancer mortality in selected countries from America, Asia, and Oceania over the 1980–2017 period and predicted numbers of deaths and rates for 2025. In North America, we observed decreased breast cancer mortality, reaching a rate of about 13/100,000 women in 2017. In Latin American countries, breast cancer mortality rates did not consistently decrease. The highest decreases in mortality were observed in Australia. Mortality trends in Asian countries remained among the lowest globally. We have predicted decreased mortality from breast cancer in 2025 for most of the analyzed countries. The epidemiological situation regarding breast cancer mortality is expected to change in the coming years. Advancements in diagnosis and treatment of breast cancer must be extended in various areas of the world to obtain global control of breast cancer mortality.

ACS Style

Cezary Wojtyla; Paola Bertuccio; Michal Ciebiera; Carlo La Vecchia. Breast Cancer Mortality in the Americas and Australasia over the Period 1980–2017 with Predictions for 2025. Biology 2021, 10, 814 .

AMA Style

Cezary Wojtyla, Paola Bertuccio, Michal Ciebiera, Carlo La Vecchia. Breast Cancer Mortality in the Americas and Australasia over the Period 1980–2017 with Predictions for 2025. Biology. 2021; 10 (8):814.

Chicago/Turabian Style

Cezary Wojtyla; Paola Bertuccio; Michal Ciebiera; Carlo La Vecchia. 2021. "Breast Cancer Mortality in the Americas and Australasia over the Period 1980–2017 with Predictions for 2025." Biology 10, no. 8: 814.

Journal article
Published: 18 July 2021 in Minimally Invasive Therapy & Allied Technologies
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Intrauterine pathologies are common in postmenopausal women and clinicians must identify signs and symptoms accurately to provide the adequate diagnosis and treatment. The quality of life (QoL) and sexuality of women are important outcomes to be considered to provide adequate clinical management of the postmenopausal patient with gynecologic pathologies. The aim of this paper is to propose a simple and replicable three-step multidisciplinary approach to evaluate the psychological outcomes of postmenopausal women with intrauterine pathologies, focusing on the role of hysteroscopy. In particular, the article describes three evaluation steps of those psychological outcomes corresponding to three fundamental moments of the patient's diagnostic and therapeutic path: the initial symptoms, diagnosis, and treatment. In our viewpoint, the standard use of such a protocol might considerably improve the QoL of postmenopausal patients undergoing hysteroscopic procedures due to intrauterine pathologies.

ACS Style

Salvatore Giovanni Vitale; Salvatore Caruso; Jose Carugno; Michał Ciebiera; Fabio Barra; Simone Ferrero; Antonio Cianci. Quality of life and sexuality of postmenopausal women with intrauterine pathologies: a recommended three-step multidisciplinary approach focusing on the role of hysteroscopy. Minimally Invasive Therapy & Allied Technologies 2021, 1 -9.

AMA Style

Salvatore Giovanni Vitale, Salvatore Caruso, Jose Carugno, Michał Ciebiera, Fabio Barra, Simone Ferrero, Antonio Cianci. Quality of life and sexuality of postmenopausal women with intrauterine pathologies: a recommended three-step multidisciplinary approach focusing on the role of hysteroscopy. Minimally Invasive Therapy & Allied Technologies. 2021; ():1-9.

Chicago/Turabian Style

Salvatore Giovanni Vitale; Salvatore Caruso; Jose Carugno; Michał Ciebiera; Fabio Barra; Simone Ferrero; Antonio Cianci. 2021. "Quality of life and sexuality of postmenopausal women with intrauterine pathologies: a recommended three-step multidisciplinary approach focusing on the role of hysteroscopy." Minimally Invasive Therapy & Allied Technologies , no. : 1-9.

Review
Published: 21 June 2021 in International Journal of Molecular Sciences
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Placental abruption is the separation of the placenta from the lining of the uterus before childbirth. It is an infrequent perinatal complication with serious after-effects and a marked risk of maternal and fetal mortality. Despite the fact that numerous placental abruption risk factors are known, the pathophysiology of this issue is multifactorial and not entirely clear. The aim of this review was to examine the current state of knowledge concerning the molecular changes on the maternal–fetal interface occurring in placental abruption. Only original research articles describing studies published in English until the 15 March 2021 were considered eligible. Reviews, book chapters, case studies, conference papers and opinions were excluded. The systematic literature search of PubMed/MEDLINE and Scopus databases identified 708 articles, 22 of which were analyzed. The available evidence indicates that the disruption of the immunological processes on the maternal–fetal interface plays a crucial role in the pathophysiology of placental abruption. The features of chronic non-infectious inflammation and augmented immunological cytotoxic response were found to be present in placental abruption samples in the reviewed studies. Various molecules participate in this process, with only a few being examined. More advanced research is needed to fully explain this complicated process.

ACS Style

Monika Bączkowska; Magdalena Zgliczyńska; Jan Faryna; Ewa Przytuła; Błażej Nowakowski; Michał Ciebiera. Molecular Changes on Maternal–Fetal Interface in Placental Abruption—A Systematic Review. International Journal of Molecular Sciences 2021, 22, 6612 .

AMA Style

Monika Bączkowska, Magdalena Zgliczyńska, Jan Faryna, Ewa Przytuła, Błażej Nowakowski, Michał Ciebiera. Molecular Changes on Maternal–Fetal Interface in Placental Abruption—A Systematic Review. International Journal of Molecular Sciences. 2021; 22 (12):6612.

Chicago/Turabian Style

Monika Bączkowska; Magdalena Zgliczyńska; Jan Faryna; Ewa Przytuła; Błażej Nowakowski; Michał Ciebiera. 2021. "Molecular Changes on Maternal–Fetal Interface in Placental Abruption—A Systematic Review." International Journal of Molecular Sciences 22, no. 12: 6612.

Journal article
Published: 23 April 2021 in Ginekologia Polska
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Uterine fibroids (UF) are the most common benign tumors of the female reproductive organ. It is crucial to recognize that the appropriate treatment of UFs requires an individualized approach. The present paper aimed at the presentation of the five-year experience of our center in the treatment of UFs with the use of magnetic resonance-guided high-intensity ultrasound (MR-HIFU) therapy. The study enrolled a total of 1284 patients with symptomatic UFs. The Sonalleve MR-HIFU system (Philips Ingenia 3.0T System) was used for magnetic resonance imaging (MRI) qualification and treatment. The group of patients qualified for thermal ablation included 356 (28%) women. No significant differences were observed between the group undergoing thermal ablation and patients who were disqualified. A complete procedure was performed in 22.6% of patients who presented at the center. Non-perfused volume (NPV) is one of the most important parameters assessed during MR-HIFU procedures. The mean NPV value in the present study was 71%. The average UF volumes decreased by 27% at three-month follow-up ultrasound, by 34% after six months and by 39% as shown by MRI measurements performed 6 months post-treatment. According to our data, MR-HIFU therapy is associated with good clinical outcomes in patients with symptomatic UFs. The method facilitates a marked symptom reduction and, in many cases, diminishing tumor volume. The presented five-year outcomes as regards our experience in the MR-HIFU therapy of patients with symptomatic UFs indicate that the method offers an attractive alternative to the traditional methods of UF treatment in selected cases.

ACS Style

Tomasz Lozinski; Justyna Filipowska; Magdalena Pyka; Monika Baczkowska; Michal Ciebiera. MR-HIFU effectiveness and usefulness in the treatment of symptomatic uterine fibroids – a 5-year experience of a leading Polish center. Ginekologia Polska 2021, 1 .

AMA Style

Tomasz Lozinski, Justyna Filipowska, Magdalena Pyka, Monika Baczkowska, Michal Ciebiera. MR-HIFU effectiveness and usefulness in the treatment of symptomatic uterine fibroids – a 5-year experience of a leading Polish center. Ginekologia Polska. 2021; ():1.

Chicago/Turabian Style

Tomasz Lozinski; Justyna Filipowska; Magdalena Pyka; Monika Baczkowska; Michal Ciebiera. 2021. "MR-HIFU effectiveness and usefulness in the treatment of symptomatic uterine fibroids – a 5-year experience of a leading Polish center." Ginekologia Polska , no. : 1.

Journal article
Published: 16 April 2021 in Diagnostics
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Objective: The assessment of the usefulness of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) when qualifying patients with uterine fibroids (UFs) for magnetic resonance-guided high-intensity ultrasound (MR-HIFU). Material and methods: This retrospective, single center study included 283 women who underwent DCE-MRI and were treated with MR-HIFU. The patients were divided according to non-perfused volume (NPV) as well as by the type of curve for patients with a washout curve in the DCE-MRI study and patients without a washout curve. The studied women were assessed in three groups according to the type of uterotonics administered. Group A (57 patients) received one dose of misoprostol/diclofenac transvaginally and group B (71 patients) received oxytocin intravenously prior to the MR-HIFU procedure. The remaining 155 women (group C) were treated with the traditional non-drug enhanced MR-HIFU procedure. Results: The average NPV value was higher in no washout group, and depended on the uterotonics used. Conclusions: We demonstrated a correlation between dynamic contrast enhancement curve types and the therapeutic efficacy of MR-HIFU. Our results suggest that DCE-MRI has the potential to assess treatment outcomes among patients with UFs, and patients with UFs that present with a washout curve may benefit from the use of uterotonic drugs. More studies are required to draw final conclusions.

ACS Style

Tomasz Łoziński; Michał Ciebiera; Elżbieta Łuczyńska; Justyna Filipowska; Artur Czekierdowski. Magnetic Resonance-Guided High-Intensity Focused Ultrasound Ablation of Uterine Fibroids—Efficiency Assessment with the Use of Dynamic Contrast-Enhanced Magnetic Resonance Imaging and the Potential Role of the Administration of Uterotonic Drugs. Diagnostics 2021, 11, 715 .

AMA Style

Tomasz Łoziński, Michał Ciebiera, Elżbieta Łuczyńska, Justyna Filipowska, Artur Czekierdowski. Magnetic Resonance-Guided High-Intensity Focused Ultrasound Ablation of Uterine Fibroids—Efficiency Assessment with the Use of Dynamic Contrast-Enhanced Magnetic Resonance Imaging and the Potential Role of the Administration of Uterotonic Drugs. Diagnostics. 2021; 11 (4):715.

Chicago/Turabian Style

Tomasz Łoziński; Michał Ciebiera; Elżbieta Łuczyńska; Justyna Filipowska; Artur Czekierdowski. 2021. "Magnetic Resonance-Guided High-Intensity Focused Ultrasound Ablation of Uterine Fibroids—Efficiency Assessment with the Use of Dynamic Contrast-Enhanced Magnetic Resonance Imaging and the Potential Role of the Administration of Uterotonic Drugs." Diagnostics 11, no. 4: 715.

Review
Published: 02 April 2021 in Nutrients
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Diet and nutrition are fundamental in maintaining the general health of populations, including women’s health. Health status can be affected by nutrient deficiency and vice versa. Gene–nutrient interactions are important contributors to health management and disease prevention. Nutrition can alter gene expression, as well as the susceptibility to diseases, including cancer, through several mechanisms. Gynecological diseases in general are diseases involving the female reproductive system and include benign and malignant tumors, infections, and endocrine diseases. Benign diseases such as uterine fibroids and endometriosis are common, with a negative impact on women’s quality of life, while malignant tumors are among the most common cause of death in the recent years. In this comprehensive review article, a bibliographic search was performed for retrieving information about nutrients and how their deficiencies can be associated with gynecological diseases, namely polycystic ovary syndrome, infertility, uterine fibroids, endometriosis, dysmenorrhea, and infections, as well as cervical, endometrial, and ovarian cancers. Moreover, we discussed the potential beneficial impact of promising natural compounds and dietary supplements on alleviating these significant diseases.

ACS Style

Michał Ciebiera; Sahar Esfandyari; Hiba Siblini; Lillian Prince; Hoda Elkafas; Cezary Wojtyła; Ayman Al-Hendy; Mohamed Ali. Nutrition in Gynecological Diseases: Current Perspectives. Nutrients 2021, 13, 1178 .

AMA Style

Michał Ciebiera, Sahar Esfandyari, Hiba Siblini, Lillian Prince, Hoda Elkafas, Cezary Wojtyła, Ayman Al-Hendy, Mohamed Ali. Nutrition in Gynecological Diseases: Current Perspectives. Nutrients. 2021; 13 (4):1178.

Chicago/Turabian Style

Michał Ciebiera; Sahar Esfandyari; Hiba Siblini; Lillian Prince; Hoda Elkafas; Cezary Wojtyła; Ayman Al-Hendy; Mohamed Ali. 2021. "Nutrition in Gynecological Diseases: Current Perspectives." Nutrients 13, no. 4: 1178.

Journal article
Published: 04 March 2021 in Diagnostics
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Background: Abnormal uterine bleeding (AUB) represents a common diagnostic challenge, as it might be related to both benign and malignant conditions. Endometrial cancer may not be detected with blind uterine cavity sampling by dilatation and curettage or suction devices. Several scoring systems using different ultrasound image characteristics were recently proposed to estimate the risk of endometrial cancer (EC) in women with AUB. Aim: The aim of the present study was to externally validate the predictive value of the recently proposed scoring systems including the Risk of Endometrial Cancer scoring model (REC) for EC risk stratification. Material and methods: It was a retrospective cohort study of women with postmenopausal bleeding. From June 2012 to June 2020 we studied a group of 394 women who underwent standard transvaginal ultrasound examination followed by power Doppler intrauterine vascularity assessment. Selected ultrasound features of endometrial lesions were assessed in each patient. Results: The median age was 60.3 years (range ± 10.7). The median body mass index (BMI) was 30.4 (range ± 6.0). Histological examination revealed 158 cases of endometrial hyperplasia (EH) and 236 cases of EC. Of the studied ultrasound endometrial features, the highest areas under the curve (AUCs) were found for endometrial thickness (ET) (AUC = 0.76; 95% CI: 0.71–0.81) and for interrupted endomyometrial junction (AUC = 0.70, 95% CI: 0.65–0.75). Selected scoring systems presented moderate to good predictive performance in differentiating EC and EH. The highest AUC was found for REC model (AUC = 0.75, 95% CI: 0.70–0.79) and for the basic model that included ET, Doppler score and interrupted endometrial junction (AUC = 0.77, 95% CI: 0.73–0.82). REC model was more accurate than other scoring systems and selected single features for differentiating benign hyperplasia from EC at early stages, regardless of menopausal status. Conclusions: New scoring systems, including the REC model may be used in women with AUB for more efficient differentiation between benign and malignant conditions.

ACS Style

Norbert Stachowicz; Agata Smoleń; Michał Ciebiera; Tomasz Łoziński; Paweł Poziemski; Dariusz Borowski; Artur Czekierdowski. Risk Assessment of Endometrial Hyperplasia or Endometrial Cancer with Simplified Ultrasound-Based Scoring Systems. Diagnostics 2021, 11, 442 .

AMA Style

Norbert Stachowicz, Agata Smoleń, Michał Ciebiera, Tomasz Łoziński, Paweł Poziemski, Dariusz Borowski, Artur Czekierdowski. Risk Assessment of Endometrial Hyperplasia or Endometrial Cancer with Simplified Ultrasound-Based Scoring Systems. Diagnostics. 2021; 11 (3):442.

Chicago/Turabian Style

Norbert Stachowicz; Agata Smoleń; Michał Ciebiera; Tomasz Łoziński; Paweł Poziemski; Dariusz Borowski; Artur Czekierdowski. 2021. "Risk Assessment of Endometrial Hyperplasia or Endometrial Cancer with Simplified Ultrasound-Based Scoring Systems." Diagnostics 11, no. 3: 442.

Clinical research
Published: 26 February 2021 in Archives of Medical Science
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Introduction Smoking during pregnancy is a risk factor for adverse pregnancy outcomes. Data on the correlation between passive maternal smoking and pregnancy outcomes remain limited. We investigated the effect of active smoking and environmental tobacco smoke (ETS) during pregnancy on neonatal birthweight, including the risk for low birthweight (LBW). Material and methods The study was conducted between 2010 and 2012. A group of 8625 women were surveyed during postpartum hospitalization. Outcome measures included mean birthweight of newborns. Additionally, odds ratios with confidence intervals were calculated to investigate the risk for LBW in active and passive smoking groups of mothers. Results Lower birthweight (46 g – 307 g; p < 0.05) and a higher risk for LBW (OR = 1.35, 95% CI: 1.05–1.75; p < 0.05) were observed in all infants born to smoking mothers. A negative effect of ETS in pregnancy on the reduction of mean birthweight was also found. Additionally, we analyzed the cumulative effect of active and passive smoking on neonatal birthweight. A statistically significant reduction in neonatal weight at birth was found in a group of women who smoked actively and passively during pregnancy (130 g; p < 0.05). Conclusions Smoking is associated with decreased birthweight and in a group of active smoking mothers increased risk for LBW. This effect is dose-dependent and is also present in a group of women who smoked before pregnancy. There is also a cumulative effect of active smoking and ETS causing decreased neonatal birthweight and increased risk for low birthweight.

ACS Style

Cezary Wojtyła; Paulina Wojtyła-Buciora; Michał Ciebiera; Stanislaw Orzechowski; Andrzej Wojtyła. The effect of active and passive maternal smoking before and during pregnancy on neonatal weight at birth. Archives of Medical Science 2021, 17, 352 -360.

AMA Style

Cezary Wojtyła, Paulina Wojtyła-Buciora, Michał Ciebiera, Stanislaw Orzechowski, Andrzej Wojtyła. The effect of active and passive maternal smoking before and during pregnancy on neonatal weight at birth. Archives of Medical Science. 2021; 17 (2):352-360.

Chicago/Turabian Style

Cezary Wojtyła; Paulina Wojtyła-Buciora; Michał Ciebiera; Stanislaw Orzechowski; Andrzej Wojtyła. 2021. "The effect of active and passive maternal smoking before and during pregnancy on neonatal weight at birth." Archives of Medical Science 17, no. 2: 352-360.

Journal article
Published: 11 January 2021 in International Journal of Environmental Research and Public Health
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Obesity and diabetes increase the risk of complications during gestation and at delivery. The aim of this study was to compare the perinatal outcomes in the populations of diabetic and obese Polish women, based on the results of a national survey performed in years 2012 and 2017, as well as to determine the risk factors of the gestational diabetes mellitus (GDM). Questionnaires from 6276 women were collected. Obese women constituted 5.5% and 7.5% of study population in years 2012 and 2017, respectively. Among women whose pregnancies were complicated by diabetes mellitus, GDM constituted the most common type of glucose intolerance during both time periods (2012: 89% vs. 2017: 85.6%). In the group of obese women an insignificant increase in the rate of induced deliveries was noted (2012: 9.9% vs. 2017: 11.7%), whereas the fetal birth-weight decreased significantly (2012: 3565g vs. 2017: 3405g, p < 0.05). In the group of diabetic pregnant women the percentage of cesarean sections, labour inductions and fetal birth defects was characterized by an insignificant upward trend. Risk of GDM was significantly increased in women aged over 35 years—(2012: OR 1.9 (95% CI: 1.1–2.9) and 2017: OR = 2.1 (95% CI: 1.5–2.9), p < 0.05—, as well as in overweight women—2012: OR 1.8 (95% CI: 1.2–2.7) and 2017: OR 2.6 (95% CI: 1.9–3.4), p < 0.05—during both analysed time periods. Based on the study results, it is necessary to develop population-based programmes to prevent obesity and to introduce and enforce the rules of appropriate screening for glucose tolerance disorders during pregnancy.

ACS Style

Cezary Wojtyla; Pawel Stanirowski; Pawel Gutaj; Michal Ciebiera; Andrzej Wojtyla. Perinatal Outcomes in a Population of Diabetic and Obese Pregnant Women—The Results of the Polish National Survey. International Journal of Environmental Research and Public Health 2021, 18, 560 .

AMA Style

Cezary Wojtyla, Pawel Stanirowski, Pawel Gutaj, Michal Ciebiera, Andrzej Wojtyla. Perinatal Outcomes in a Population of Diabetic and Obese Pregnant Women—The Results of the Polish National Survey. International Journal of Environmental Research and Public Health. 2021; 18 (2):560.

Chicago/Turabian Style

Cezary Wojtyla; Pawel Stanirowski; Pawel Gutaj; Michal Ciebiera; Andrzej Wojtyla. 2021. "Perinatal Outcomes in a Population of Diabetic and Obese Pregnant Women—The Results of the Polish National Survey." International Journal of Environmental Research and Public Health 18, no. 2: 560.

Review
Published: 31 October 2020 in International Journal of Environmental Research and Public Health
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Background: Cesarean section is a surgical procedure, which is the most frequently performed in gynecology and obstetrics. It is commonly believed that an operative delivery is a less painful and safer mode of delivery, which translates into an increasing number of the procedures performed without medical indications. The maternal sequelae of cesarean sections are well elucidated and widely discussed in the literature, while long-term neonatal consequences still remain the issue of research and scientific dispute. The aim of the present paper was to perform a systematic review of current literature regarding pediatrics consequences of cesarean section. Methods: We reviewed available data from PubMed, Science Direct as well as Google Scholar bases concerning early and long-term neonatal sequelae of operative deliveries. The following key words were used: “cesarean section”, “caesarean section”, “neonatal outcomes”, “respiratory disorders”, “asthma”, “obesity”, “overweight”, and “neurological disorders”. A total of 1636 papers were retrieved out of which 27 were selected for the final systematic review whereas 16 articles provided data for meta-analysis. Statistical analyses were performed using RevMan 5.4. To determine the strength of association between the caesarean section and respiratory tract infections, asthma, diabetes type 1 as well as obesity the pooled odds ratios (OR) with the 95% confidence intervals (CI) were calculated. Results: Conducted meta-analyses revealed that caesarean section is a risk factor for respiratory tract infections (pooled OR = 1.30 95%CI 1.06–1.60, p = 0.001), asthma (pooled OR = 1.23 95%CI 1.14–1.33, p < 0.00001) as well as obesity (pooled OR = 1.35 95%CI 1.29–1.41, p < 0.00001) in offspring. Conclusions: The results of the studies included indicated that children delivered by cesarean section more commonly developed respiratory tract infections, obesity and the manifestations of asthma than children delivered vaginally. The risk of developing diabetes mellitus type 1 or neurological disorders in offspring after caesarean section is still under discussion.

ACS Style

Aneta Słabuszewska-Jóźwiak; Jacek Szymański; Michał Ciebiera; Beata Sarecka-Hujar; Grzegorz Jakiel. Pediatrics Consequences of Caesarean Section—A Systematic Review and Meta-Analysis. International Journal of Environmental Research and Public Health 2020, 17, 8031 .

AMA Style

Aneta Słabuszewska-Jóźwiak, Jacek Szymański, Michał Ciebiera, Beata Sarecka-Hujar, Grzegorz Jakiel. Pediatrics Consequences of Caesarean Section—A Systematic Review and Meta-Analysis. International Journal of Environmental Research and Public Health. 2020; 17 (21):8031.

Chicago/Turabian Style

Aneta Słabuszewska-Jóźwiak; Jacek Szymański; Michał Ciebiera; Beata Sarecka-Hujar; Grzegorz Jakiel. 2020. "Pediatrics Consequences of Caesarean Section—A Systematic Review and Meta-Analysis." International Journal of Environmental Research and Public Health 17, no. 21: 8031.

Review
Published: 27 October 2020 in Reproductive Sciences
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Uterine fibroids (UFs) are benign tumors originating from smooth muscle cells and are considered a common pathology that affects numerous women which is a notable socio-economic problem. Several UF risk factors have been identified including black race, obesity, and vitamin D deficiency. Vitamin D is steroid compound with pleiotropic effects on the human body. Vitamin D deficiency is a major public health concern worldwide. Several studies have shown that the majority of UF patients experienced hypovitaminosis D. In addition, sufficient vitamin D serum levels are associated with the reduced risk of UFs. In this review, we present available data highlighting the importance of measuring vitamin D serum levels in women with UFs and women at a high risk for UF development. We proposed a preliminary clinical instruction of 25-hydroxyvitamin D measurements and vitamin D supplementation for clinicians who are involved in the treatment of patients with UFs. Achieving sufficient serum levels of vitamin D might be of interest in patients with UFs. Screening, supplementation, treatment guidelines, and public health strategies for vitamin D deficiency in women with UFs as well as women at a high risk of UF development might be of potential importance as well.

ACS Style

Michał Ciebiera; Mohamed Ali; Lillian Prince; Stanisław Zgliczyński; Grzegorz Jakiel; Ayman Al-Hendy. The Significance of Measuring Vitamin D Serum Levels in Women with Uterine Fibroids. Reproductive Sciences 2020, 28, 1 -12.

AMA Style

Michał Ciebiera, Mohamed Ali, Lillian Prince, Stanisław Zgliczyński, Grzegorz Jakiel, Ayman Al-Hendy. The Significance of Measuring Vitamin D Serum Levels in Women with Uterine Fibroids. Reproductive Sciences. 2020; 28 (8):1-12.

Chicago/Turabian Style

Michał Ciebiera; Mohamed Ali; Lillian Prince; Stanisław Zgliczyński; Grzegorz Jakiel; Ayman Al-Hendy. 2020. "The Significance of Measuring Vitamin D Serum Levels in Women with Uterine Fibroids." Reproductive Sciences 28, no. 8: 1-12.

Journal article
Published: 11 September 2020 in Annals of Agricultural and Environmental Medicine
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Introduction: Adverse pregnancy outcomes are less common among physically active women, and children born to such mothers are less likely to be at risk for macrosomia, obesity and metabolic diseases in the future. Objectives: The aims of the study were to establish physical activity (PA)...

ACS Style

Cezary Wojtyła; Michał Ciebiera; Paulina Wojtyła-Buciora; Anna Janaszczyk; Paulina Brzęcka; Andrzej Wojtyła. Physical activity patterns in third trimester of pregnancy – use of pregnancy physical activity questionnaire in Poland. Annals of Agricultural and Environmental Medicine 2020, 27, 388 -393.

AMA Style

Cezary Wojtyła, Michał Ciebiera, Paulina Wojtyła-Buciora, Anna Janaszczyk, Paulina Brzęcka, Andrzej Wojtyła. Physical activity patterns in third trimester of pregnancy – use of pregnancy physical activity questionnaire in Poland. Annals of Agricultural and Environmental Medicine. 2020; 27 (3):388-393.

Chicago/Turabian Style

Cezary Wojtyła; Michał Ciebiera; Paulina Wojtyła-Buciora; Anna Janaszczyk; Paulina Brzęcka; Andrzej Wojtyła. 2020. "Physical activity patterns in third trimester of pregnancy – use of pregnancy physical activity questionnaire in Poland." Annals of Agricultural and Environmental Medicine 27, no. 3: 388-393.

Journal article
Published: 01 September 2020 in Journal of Complementary and Integrative Medicine
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Endometriosis is a benign gynecological disease which symptoms can provide a severe impact on patient’s quality of life with subsequent impact on psychological well-being. Different therapeutic strategies are available to treat this disease, such as surgery, hormonal therapies, and nonsteroidal anti-inflammatory drugs. Nevertheless, the efficacy of conventional medical treatments is limited or intermittent in most of the patients due to the associated side effects. Therefore, a woman with endometriosis often search for additional and alternative options, and phytotherapy might be a promising alternative and complementary strategy. Different medicinal plants, multicomponent herbal preparations, and phytochemicals were investigated for pharmacological proprieties in endometriosis therapy. In most of the cases, the effect on endometriosis was related to phenolic compounds, such as flavonoids and phenolic acids reporting anti-inflammatory, proapoptotic, antioxidant, and immunomodulatory functions. Moreover, some phytochemicals have been related to a strong phytoestrogenic effect modulating the estrogen activity. Although promising, available evidence is based on in vitro and animal models of endometriosis with a limited number of well-performed clinical studies. There are almost none randomized control trials in this area. Therefore, properly constructed clinical trials are mandatory to achieve more conclusive results about the promising role of phytotherapy in the management of endometriosis.

ACS Style

Luigi Della Corte; Marco Noventa; Michal Ciebiera; Maria Magliarditi; Zaki Sleiman; Erbil Karaman; Ursula Catena; Calogero Salvaggio; Giovanni Falzone; Simone Garzon. Phytotherapy in endometriosis: an up-to-date review. Journal of Complementary and Integrative Medicine 2020, 17, 1 .

AMA Style

Luigi Della Corte, Marco Noventa, Michal Ciebiera, Maria Magliarditi, Zaki Sleiman, Erbil Karaman, Ursula Catena, Calogero Salvaggio, Giovanni Falzone, Simone Garzon. Phytotherapy in endometriosis: an up-to-date review. Journal of Complementary and Integrative Medicine. 2020; 17 (3):1.

Chicago/Turabian Style

Luigi Della Corte; Marco Noventa; Michal Ciebiera; Maria Magliarditi; Zaki Sleiman; Erbil Karaman; Ursula Catena; Calogero Salvaggio; Giovanni Falzone; Simone Garzon. 2020. "Phytotherapy in endometriosis: an up-to-date review." Journal of Complementary and Integrative Medicine 17, no. 3: 1.

Review
Published: 01 August 2020 in International Journal of Molecular Sciences
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Uterine fibroid (UF) is the most common benign tumor pathology of the female reproductive organs. UFs constitute the main reason for a hysterectomy and hospitalization due to gynecological conditions. UFs consist of uterine smooth muscle immersed in a large amount of extracellular matrix (ECM). Genetic studies have demonstrated that UFs are monoclonal tumors originating from the myometrial stem cells that have underwent specific molecular changes to tumor initiating stem cells which proliferate and differentiate later under the influence of steroid hormones. There is growing interest in the role of micronutrients, for example, vitamins, in UFs. This article is a comprehensive review of publications regarding the available data concerning the role of vitamins in the biology and management of UFs. In summary, the results showed that some vitamins are important in the biology and pathophysiology of UFs. For example, vitamins A and D deserve particular attention following studies of their influence on the treatment of UF tumors. Vitamins B3, C, and E have not been as widely studied as the abovementioned vitamins. However, more research could reveal their potential role in UF biology.

ACS Style

Michał Ciebiera; Mohamed Ali; Magdalena Zgliczyńska; Maciej Skrzypczak; Ayman Al-Hendy. Vitamins and Uterine Fibroids: Current Data on Pathophysiology and Possible Clinical Relevance. International Journal of Molecular Sciences 2020, 21, 5528 .

AMA Style

Michał Ciebiera, Mohamed Ali, Magdalena Zgliczyńska, Maciej Skrzypczak, Ayman Al-Hendy. Vitamins and Uterine Fibroids: Current Data on Pathophysiology and Possible Clinical Relevance. International Journal of Molecular Sciences. 2020; 21 (15):5528.

Chicago/Turabian Style

Michał Ciebiera; Mohamed Ali; Magdalena Zgliczyńska; Maciej Skrzypczak; Ayman Al-Hendy. 2020. "Vitamins and Uterine Fibroids: Current Data on Pathophysiology and Possible Clinical Relevance." International Journal of Molecular Sciences 21, no. 15: 5528.

Journal article
Published: 01 August 2020 in International Journal of Environmental Research and Public Health
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Purpose: Comparison of the activity of 11beta-hydroxysteroid dehydrogenase type 2 in the placenta and the umbilical cord blood cortisol level between caesarean sections with or without uterine contraction and vaginal delivery groups. Cortisol is the main stress hormone responsible for the normal adaptation of the neonate to extrauterine life. The disorders resulting from a dysfunction of the 11β-HSD 2–cortisol system can explain the higher risk of developing diseases in children born by caesarean section. Methods: 111 healthy, pregnant women in singular pregnancy at term of delivery were included into the study. The study comprised 11β-HSD 2 in placental tissue from 49 pregnant women delivering by elective caesarean section and 46 pregnant women delivering by vagina. In 16 cases of the elective caesarean section, regular uterine contractions were declared. Cortisol level was estimated in umbilical cord blood directly after delivery. Results: We found no statistically significant differences in the activity of 11β-HSD 2 in placentas delivered via caesarean sections (29.61 on average in elective caesarean sections and 26.65 on average in intrapartum caesarean sections) compared to vaginal deliveries (31.94 on average, p = 0.381), while umbilical cord blood cortisol in the elective caesarean sections group was significantly lower (29.86 on average) compared to the vaginal deliveries (55.50 on average, p < 0.001) and intrapartum caesarean sections (52.27 on average, p < 0.001). Conclusions: The model of placental 11β-HSD 2 activity and umbilical cord blood cortisol concentration seems to be significant in conditions of stress associated with natural uterine contractions in labour.

ACS Style

Aneta Słabuszewska-Jóżwiak; Marta Włodarczyk; Krzysztof Kilian; Zbigniew Rogulski; Michał Ciebiera; Jolanta Szymańska-Majchrzak; Kornelia Zaręba; Jacek Krzysztof Szymański; Dorota Raczkiewicz; Grażyna Nowicka; Grzegorz Jakiel. Does the Caesarean Section Impact on 11β HSD2 and Fetal Cortisol? International Journal of Environmental Research and Public Health 2020, 17, 5566 .

AMA Style

Aneta Słabuszewska-Jóżwiak, Marta Włodarczyk, Krzysztof Kilian, Zbigniew Rogulski, Michał Ciebiera, Jolanta Szymańska-Majchrzak, Kornelia Zaręba, Jacek Krzysztof Szymański, Dorota Raczkiewicz, Grażyna Nowicka, Grzegorz Jakiel. Does the Caesarean Section Impact on 11β HSD2 and Fetal Cortisol? International Journal of Environmental Research and Public Health. 2020; 17 (15):5566.

Chicago/Turabian Style

Aneta Słabuszewska-Jóżwiak; Marta Włodarczyk; Krzysztof Kilian; Zbigniew Rogulski; Michał Ciebiera; Jolanta Szymańska-Majchrzak; Kornelia Zaręba; Jacek Krzysztof Szymański; Dorota Raczkiewicz; Grażyna Nowicka; Grzegorz Jakiel. 2020. "Does the Caesarean Section Impact on 11β HSD2 and Fetal Cortisol?" International Journal of Environmental Research and Public Health 17, no. 15: 5566.

Research article
Published: 09 July 2020 in The European Journal of Contraception & Reproductive Health Care
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The study aimed to determine the influence of religious and moral beliefs on contraceptive use, assisted reproduction and pregnancy termination in Polish women requesting a termination of pregnancy for medical reasons. Between 1 June 2014 and 31 May 2016, women deemed eligible for a termination of pregnancy for medical reasons at a Polish tertiary care centre received an anonymous questionnaire comprising 65 items. A total of 150 completed questionnaires were collected. Of the respondents, 95% described themselves as Catholics, including 60% practising Catholics. The study revealed a discrepancy between respondents’ beliefs and the teachings of the Catholic Church: an overwhelming majority of respondents used contraception, and 79% were in favour of in vitro fertilisation and believed the treatment should be refunded by the state. Interestingly, 66% of the respondents who attended confession did not perceive abortion as sinful. The study detected a considerable discrepancy between declared religiosity and individual interpretations of the commandments and teachings of the Catholic Church. Despite stating they were Catholics, most women did not perceive abortion as sinful and did not follow the teachings of the Catholic Church regarding the sacraments for deceased children.

ACS Style

Kornelia Zaręba; Elena Commodari; Valentina Lucia La Rosa; Marta Makara-Studzińska; Michał Ciebiera; Jacek Gierus; Salvatore Caruso; Grzegorz Jakiel. Religiosity among women undergoing pregnancy termination for medical reasons: the experiences and views of Polish women. The European Journal of Contraception & Reproductive Health Care 2020, 25, 381 -386.

AMA Style

Kornelia Zaręba, Elena Commodari, Valentina Lucia La Rosa, Marta Makara-Studzińska, Michał Ciebiera, Jacek Gierus, Salvatore Caruso, Grzegorz Jakiel. Religiosity among women undergoing pregnancy termination for medical reasons: the experiences and views of Polish women. The European Journal of Contraception & Reproductive Health Care. 2020; 25 (5):381-386.

Chicago/Turabian Style

Kornelia Zaręba; Elena Commodari; Valentina Lucia La Rosa; Marta Makara-Studzińska; Michał Ciebiera; Jacek Gierus; Salvatore Caruso; Grzegorz Jakiel. 2020. "Religiosity among women undergoing pregnancy termination for medical reasons: the experiences and views of Polish women." The European Journal of Contraception & Reproductive Health Care 25, no. 5: 381-386.

Review
Published: 03 July 2020 in Journal of Clinical Medicine
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The aim of this review was to summarize the available evidence about the use of levonorgestrel-releasing intrauterine system (LNG-IUS) as a contraceptive method in nulliparous women. For this purpose, studies evaluating the efficacy, safety, bleeding pattern, satisfaction and discontinuation of the levonorgestrel-releasing intrauterine system in nulliparous women were analyzed. Only original research articles published in English between 1990–27th March 2020 were considered eligible. Reviews, book chapters, case studies, conference papers, opinions, editorials and letters were excluded. The systematic literature search of PubMed/MEDLINE, Scopus, Embase and Cochrane Library databases identified 816 articles, 23 of which were analyzed. The available evidence indicates that LNG-IUS is an effective and safe contraceptive method for nulliparous women that achieves high levels of satisfaction among patients. Moreover, nulliparous women seem to experience fewer expulsions than parous ones. Bleeding pattern is acceptable for the majority of patients, and bleeding disorders mainly occur in the first months after the insertion. More in-depth, long-term prospective studies are needed in this patient group to determine risk factors for the occurrence of side effects and associated discontinuations, which should not, however, delay the wider use of the method in this group, given the number of advantages.

ACS Style

Magdalena Zgliczynska; Karol Kocaj; Iwona Szymusik; Magdalena Maria Dutsch-Wicherek; Michal Ciebiera; Katarzyna Kosinska-Kaczynska. Levonorgestrel-Releasing Intrauterine System as a Contraceptive Method in Nulliparous Women: A Systematic Review. Journal of Clinical Medicine 2020, 9, 2101 .

AMA Style

Magdalena Zgliczynska, Karol Kocaj, Iwona Szymusik, Magdalena Maria Dutsch-Wicherek, Michal Ciebiera, Katarzyna Kosinska-Kaczynska. Levonorgestrel-Releasing Intrauterine System as a Contraceptive Method in Nulliparous Women: A Systematic Review. Journal of Clinical Medicine. 2020; 9 (7):2101.

Chicago/Turabian Style

Magdalena Zgliczynska; Karol Kocaj; Iwona Szymusik; Magdalena Maria Dutsch-Wicherek; Michal Ciebiera; Katarzyna Kosinska-Kaczynska. 2020. "Levonorgestrel-Releasing Intrauterine System as a Contraceptive Method in Nulliparous Women: A Systematic Review." Journal of Clinical Medicine 9, no. 7: 2101.

Journal article
Published: 28 June 2020 in International Journal of Environmental Research and Public Health
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Changes that took place in Europe in the early 1990s had an impact on health-associated issues. They were an impulse for the changes in healthcare systems and, consequently, also for the changes in cancer control programmes. Those changes also had an effect on mortality rates due to cervical cancer (CC). Therefore, the aim of this study is to analyse CC mortality trends in east-central Europe after 1990. Data on deaths due to CC were retrieved from the WHO Mortality Database. Trends in east-central European countries between 1990 and 2017 were assessed using Joinpoint Regression Program software. CC mortality decreased in the majority of analysed countries. However, an increase was observed in Latvia and Bulgaria. Despite decreasing mortality in the majority of the analysed countries, significant differences were observed. In order to improve the epidemiological situation, effective early detection programmes for cervical cancer ought to be rearranged and based not only on pap smears but also on molecular methods, as well as on introducing widespread programmes of vaccination against HPV.

ACS Style

Cezary Wojtyla; Michal Ciebiera; Dariusz Kowalczyk; Grzegorz Panek. Cervical Cancer Mortality in East-Central European Countries. International Journal of Environmental Research and Public Health 2020, 17, 4639 .

AMA Style

Cezary Wojtyla, Michal Ciebiera, Dariusz Kowalczyk, Grzegorz Panek. Cervical Cancer Mortality in East-Central European Countries. International Journal of Environmental Research and Public Health. 2020; 17 (13):4639.

Chicago/Turabian Style

Cezary Wojtyla; Michal Ciebiera; Dariusz Kowalczyk; Grzegorz Panek. 2020. "Cervical Cancer Mortality in East-Central European Countries." International Journal of Environmental Research and Public Health 17, no. 13: 4639.

Journal article
Published: 31 May 2020 in International Journal of Environmental Research and Public Health
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Background: This paper aims to explore the attitudes and opinions of a group of Polish young gynecologists toward pregnancy termination. Method: An anonymous questionnaire was completed by physicians who participated in obligatory trainee courses held in 2019 in Warsaw. Results: The study group included 71 physicians with an average age of 29 years (SD 3.05). A considerable number of the physicians accepted terminations for medical reasons up to the end of pregnancy, especially in cases of lethal defects (46%) and a serious disease in the mother (34%). Only 6% of the group of gynecologists not performing terminations claimed that the procedure was contrary to their conscience, and 62% of them stated that such procedures were not performed at their hospital. Terminations would be performed by 90% of the respondents in cases of lethal defects of the fetus and by 80% if severe irreversible fetal defects were diagnosed. Conclusions: The main problem associated with the inaccessibility of pregnancy termination in Poland is not linked to individuals, meaning medical personnel and the possibility of invoking the conscience clause, but probably to the lack of approval for terminations granted by hospital supervisors. Adequate knowledge on pregnancy termination procedures, fetal defects, and diseases in the mother translated into the changes of opinions on pregnancy terminations.

ACS Style

Kornelia Zaręba; Valentina Lucia La Rosa; Ewelina Kołb-Sielecka; Michał Ciebiera; Rosalia Ragusa; Jacek Gierus; Elena Commodari; Grzegorz Jakiel. Attitudes and Opinions of Young Gynecologists on Pregnancy Termination: Results of a Cross-Sectional Survey in Poland. International Journal of Environmental Research and Public Health 2020, 17, 3895 .

AMA Style

Kornelia Zaręba, Valentina Lucia La Rosa, Ewelina Kołb-Sielecka, Michał Ciebiera, Rosalia Ragusa, Jacek Gierus, Elena Commodari, Grzegorz Jakiel. Attitudes and Opinions of Young Gynecologists on Pregnancy Termination: Results of a Cross-Sectional Survey in Poland. International Journal of Environmental Research and Public Health. 2020; 17 (11):3895.

Chicago/Turabian Style

Kornelia Zaręba; Valentina Lucia La Rosa; Ewelina Kołb-Sielecka; Michał Ciebiera; Rosalia Ragusa; Jacek Gierus; Elena Commodari; Grzegorz Jakiel. 2020. "Attitudes and Opinions of Young Gynecologists on Pregnancy Termination: Results of a Cross-Sectional Survey in Poland." International Journal of Environmental Research and Public Health 17, no. 11: 3895.

Journal article
Published: 26 May 2020 in Antibiotics
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Background: Urinary tract infections (UTIs) are the most common bacterial infections among kidney transplant (KTX) recipients. The purpose of this study was to analyze antimicrobial resistance (AMR) in four most common pathogens responsible for UTIs in KTX recipients and determine risk factors (RF) for resistance in the same group. Methods: Analyzed antibiograms were based on urine samples positive for bacterial growth of 105 colony-forming units (CFU)/mL obtained from hospitalized adult KTX recipients presenting with UTI symptoms upon admission to the center in years 2011–2018. Results: In total, 783 antibiograms were analyzed for Klebsiella pneumoniae (258 samples, 33.0%), Escherichia coli (212, 27.0%), Enterococcus faecalis (128, 24.0%), and Enterococcus faecium (125, 16.0%). The decrease in susceptibility of E. coli to amoxicillin/clavulanic acid (62.9% vs. 40.0%) and ciprofloxacin (100% to 40.0%) was observed. Susceptibility to gentamicin increased from 33.3% to 92.9% in E. faecium. Susceptibility to tigecycline remained 100% through all years in case of E. faecalis and E. faecium. Male gender was a RF for resistance to amoxicillin/clavulanic acid (p = 0.008), ciprofloxacin (p = 0.0003), trimethoprim/sulfamethoxazole (p = 0.00009), ceftriaxone (p = 0.0001), and cefuroxime axetil (p = 0.00038) in K. pneumoniae and against gentamicin in E. faecalis (p = 0.015). Higher resistance to ampicillin in E. faecalis (p = 0.012) and to ciprofloxacin (p = 0.0003), trimethoprim/sulfamethoxazole (p = 0.007), piperacillin/tazobactam (p = 0.003), ceftriaxone (p = 0.001), and cefuroxime axetil (p = 0.013) in K. pneumoniae was observed in higher age groups of patients. Diabetes as a cause of kidney insufficiency (p = 0.026) and kidney-pancreas transplantation (p = 0.014) was RF for resistance to ceftriaxone in K. pneumoniae. Conclusions: AMR in uropathogens from KTX recipients fluctuated. There were identifiable RFs for resistance in the examined bacteria–antibiotic combinations. We recommend continuous mapping of site-specific microorganisms as etiology and susceptibility may vary between institutions and over time.

ACS Style

Olga Maria Rostkowska; Robert Kuthan; Anna Burban; Jagoda Salińska; Michał Ciebiera; Grażyna Młynarczyk; Magdalena Durlik. Analysis of Susceptibility to Selected Antibiotics in Klebsiella pneumoniae, Escherichia coli, Enterococcus faecalis and Enterococcus faecium Causing Urinary Tract Infections in Kidney Transplant Recipients over 8 Years: Single-Center Study. Antibiotics 2020, 9, 284 .

AMA Style

Olga Maria Rostkowska, Robert Kuthan, Anna Burban, Jagoda Salińska, Michał Ciebiera, Grażyna Młynarczyk, Magdalena Durlik. Analysis of Susceptibility to Selected Antibiotics in Klebsiella pneumoniae, Escherichia coli, Enterococcus faecalis and Enterococcus faecium Causing Urinary Tract Infections in Kidney Transplant Recipients over 8 Years: Single-Center Study. Antibiotics. 2020; 9 (6):284.

Chicago/Turabian Style

Olga Maria Rostkowska; Robert Kuthan; Anna Burban; Jagoda Salińska; Michał Ciebiera; Grażyna Młynarczyk; Magdalena Durlik. 2020. "Analysis of Susceptibility to Selected Antibiotics in Klebsiella pneumoniae, Escherichia coli, Enterococcus faecalis and Enterococcus faecium Causing Urinary Tract Infections in Kidney Transplant Recipients over 8 Years: Single-Center Study." Antibiotics 9, no. 6: 284.