Konstantinia Kofina

Dr. Konstantinia Kofina


Research Focus & Metrics

Academic Career Length

12Years (2015-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

View All Publications
15 September 2022 in World Journal of Surgery
Verified
Journal Article
Open access
PDF file
Konstantinos LasithiotakisKonstantinos Lasithiotakis
Konstantinos Lasithiotakis
Evangelos I. KritsotakisEvangelos I. Kritsotakis
Evangelos I. Kritsotakis
SKStamatios Kokkinakis
Stamatios Kokkinakis
GPGeorgia Petra
Georgia Petra
KPKonstantinos Paterakis
Konstantinos Paterakis
ECEmmanuel Chrysos
Emmanuel Chrysos
Background: Emergency laparotomy (EL) is accompanied by high post‐operative morbidity and mortality which varies significantly between countries and populations. The aim of this study is to report outcomes of emergency laparotomy in Greece and to compare them with the results of the National Emergency Laparotomy Audit (NELA).Methods: This is a multicentre prospective cohort study undertaken between 01.2019 and 05.2020 including consecutive patients subjected to EL in 11 Greek hospitals. EL was defined according to NELA criteria. Demographics, clinical variables, and post‐operative outcomes were prospectively registered in an online database. Multivariable logistic regression analysis was used to identify independent predictors of post‐operative mortality.Results: There were 633 patients, 53.9% males, ASA class III/IV 43.6%, older than 65 years 58.6%. The most common operations were small bowel resection (20.5%), peptic ulcer repair (12.0%), adhesiolysis (11.8%) and Hartmann's procedure (11.5%). 30‐day post‐operative mortality reached 16.3% and serious complications occurred in 10.9%. Factors associated with post‐operative mortality were increasing age and ASA class, dependent functional status, ascites, severe sepsis, septic shock, and diabetes. HELAS cohort showed similarities with NELA patients in terms of demographics and preoperative risk. Post‐operative utilisation of ICU was significantly lower in the Greek cohort (25.8% vs 56.8%) whereas 30‐day post‐operative mortality was significantly higher (16.3% vs 8.7%).Conclusion: In this study, Greek patients experienced markedly worse mortality after emergency laparotomy compared with their British counterparts. This can be at least partly explained by underutilisation of critical care by surgical patients who are at high risk for death.

1 October 2020 in Nutrition
Verified
Journal Article
Closed access
AAAikaterini Apostolopoulou
Aikaterini Apostolopoulou
AHAnna-Bettina Haidich
Anna-Bettina Haidich
KKKonstantinia Kofina
Konstantinia Kofina
WMWilliam Manzanares
William Manzanares
EBEmmanouil Bouras
Emmanouil Bouras
MCMichael Chourdakis
Michael Chourdakis

1 August 2018 in Journal of Surgical Case Reports
Verified
Journal Article
Open access
PDF file
MKMichael Karanikas
Michael Karanikas
KKKonstantinia Kofina
Konstantinia Kofina
FAFerdi Boz Ali
Ferdi Boz Ali
VVVasileia Vamvakerou
Vasileia Vamvakerou
EEEleni Effraemidou
Eleni Effraemidou
APAlexandros Polychronidis
Alexandros Polychronidis
Greater omental torsion is a rare entity that can cause acute abdominal pain, may mimick other abdominal pathologies, and is difficult to be diagnosed preoperatively. We present a case of a male patient with greater omental torsion mimicking the symptoms of acute appendicitis. A 31-year-old male patient presented with right scrotal pain, initially treated by the urologists, however, 24 h later, he presented right lower quadrant pain, with characteristics of acute appendicitis. After finding in ischemic inflammatory mass on McBurney incision, an exploratory laparotomy was performed, revealing torsion of the greater omentum. Torsion of the greater omentum can be a cause of acute abdomen and could be misdiagnosed with acute appendicitis. Preoperative diagnosis is not easy and resection of the affected tissue is the preferred treatment of choice.

16 October 2024 in Cancers
Verified
Journal Article
Open access
PDF file
MKMICHAIL KARANIKAS
MICHAIL KARANIKAS
KKKonstantinia Kofina
Konstantinia Kofina
DKDimitrios Kyziridis
Dimitrios Kyziridis
GTGrigorios Tripsianis
Grigorios Tripsianis
AKApostolos Kalakonas
Apostolos Kalakonas
ATAntonios-Apostolos Tentes
Antonios-Apostolos Tentes
Purpose: The main objective of the study is to evaluate the effect of hyperthermic intraperitoneal chemotherapy (HIPEC) in the treatment of naïve ovarian cancer women undergoing complete or near-complete cytoreduction by assessing the overall survival, the disease-specific survival, and the disease-free survival. The secondary objective is the identification of prognostic indicators of survival and recurrence of these patients. Patients—Methods: Retrospective study of treatment in naïve women with locally advanced ovarian cancer treated with cytoreductive surgery (CRS) and HIPEC and compared with those who were treated with cytoreduction alone. Clinicopathologic variables were correlated to overall survival, disease-specific survival, and disease-free survival using Kaplan–Meier method, and the multivariate Cox proportional hazards regression models. Results: 5- and 10-year overall survival, disease-specific survival, and disease-free survival rates were significantly higher in patients treated with CRS and HIPEC. These patients were 67% less likely to die from any cause (adjusted hazard ratio, aHR = 0.33, p = 0.001), 75% less likely to die from cancer (aHR = 0.25, p = 0.003), and 46% less likely to develop recurrence (aHR = 0.54, p = 0.041) compared to patients treated with CRS alone. Moreover, the poor performance status (aHR = 2.96, p < 0.001), the serous carcinomas (aHR = 0.14, p = 0.007), and the morbidity (aHR = 6.87, p < 0.001) were identified as independent indicators of poor overall survival. The degree of differentiation (aHR = 8.64, p = 0.003) was identified as the independent indicator of disease-specific survival (aHR = 4.13, p = 0.002), while the extent of peritoneal carcinomatosis (aHR = 2.32, p < 0.001) as the independent indicator of disease-free survival. Conclusions: Treatment in naïve patients with locally advanced ovarian cancer undergoing CRS plus HIPEC appears to have improved overall, disease-specific, and disease-free survival.

1 August 2018 in Journal of Surgical Case Reports
Verified
Journal Article
Open access
PDF file
MKMichael Karanikas
Michael Karanikas
KKKonstantinia Kofina
Konstantinia Kofina
MMMarkos Markou
Markos Markou
DDDamianos Doukas
Damianos Doukas
EEEleni Effraemidou
Eleni Effraemidou
APAlexandros Polychronidis
Alexandros Polychronidis
Metastatic tumors of the appendix is a rare entity, whereas only limited data involving metastasis arising from gastric cancer has been reported. Herein, the case of gastric adenocarcinoma metastasis presenting as acute appendicitis is reported. A 53-year-old male, with a history of subtotal gastrectomy due to gastric adenocarcinoma 3 years before, was referred to the Emergency Department with symptoms of acute appendicitis. While this condition was confirmed intraoperatively, histology examination and comparison with the previously excised gastric specimen indicated that metastasis of gastric adenocarcinoma to the appendix was present. Metastatic appendiceal carcinoma arising from the stomach is an extremely rare condition, associated with poor prognosis. Aggressive treatment of the solitary lesion may present favorable results.

27 June 2016 in Case Reports in Urology
Verified
Journal Article
Open access
PDF file
Daniel ParamythiotisDaniel Paramythiotis
Daniel Paramythiotis
PBPetros I. Bangeas
Petros I. Bangeas
KKKonstantinia Kofina
Konstantinia Kofina
VPVassileios Papadopoulos
Vassileios Papadopoulos
AMAntonios Michalopoulos
Antonios Michalopoulos
Introduction.Hydatid cyst disease caused byEchinococcus granulosusis rarely presented in the kidneys, whereas isolated renal occurrence is estimated to be about as low as 2–4% of all cases. We present a case of a female patient suffering from this condition that was treated successfully in our department.Case Presentation.A 44-year-old woman was incidentally diagnosed with a 14 cm left renal cystic mass through ultrasound imaging performed during upper abdominal pain investigation. Laboratory examinations were normal and CT imaging set the diagnosis of an isolated left renal hydatid cyst. The cyst was excised and the postoperative period was uneventful.Discussion.Isolated renal hydatid cyst is a very rare condition and could possibly be misdiagnosed with other renal masses. The clinical history, laboratory tests, and thorough radiologic imaging are crucial for the accurate preoperative diagnosis.