Including dispersion slope analysis derived from two-dimensional shear-wave elastography did not improve the diagnostic performance in detecting liver necroinflammation, fibrosis, or steatosis in 1... Background Little is known about the benefits of the use of dispersion slope (DS) as a viscosity-related parameter derived from two-dimensional (2D) shear-wave elastography (SWE) in the stratificat...

Two-dimensional shear-wave elastography is valuable in predicting liver-related events in patients with well-compensated cirrhosis and chronic hepatitis B viral infection; its predictive accuracy i... Background Liver stiffness measurement has been proposed as a noninvasive marker for predicting liver-related complications of cirrhosis. Purpose To evaluate the predictive value of liver stiffness...

Cyclin-dependent kinase 5 (CDK5), an atypical member of the cyclin-dependent kinase family, plays an important role in the nervous system. Recent studies have shown that CDK5 is also associated with tumors. However, few studies have been done to investigate the mechanism underlying the connection between CDK5 and cancers. To explore the role of CDK5 in cancers by using an extensive bioinformatics data mining process. We mined the transcriptional, survival, functions and structure of CDK5 gene through databases and in vitro experiments. We found that higher CDK5 expression levels in most cancer cell lines while lower expression in liver and brain cancer cell lines. High expression of CDK5 was associated with shorter overall survival (OS) in lung cancer. In addition, high expression level of CDK5 promoted lung cancer cells proliferation and metastasis. Inhibited CDK5 decreases CAP1 phosphorylation. CDK5 may prove to be a valid target of anticancer therapies.

A multiparametric US predictive model combining attenuation coefficient, alanine aminotransferase level, and international normalized ratio showed good ability to predict metabolic dysfunction–asso... Background Noninvasive evaluation of metabolic dysfunction–associated fatty liver disease (MAFLD) with multiparametric US is essential, but multicenter studies are lacking. Purpose To evaluate the ...

A hepatocellular carcinoma (HCC) prediction score constructed from age, platelet count, and liver stiffness measurement at two-dimensional shear-wave elastography, or APS score, higher than 60 is p... Background Two-dimensional (2D) shear-wave elastography (SWE) has been considered to be useful in predicting hepatocellular carcinoma (HCC) development in patients with chronic hepatitis B (CHB). P...