Yifan Zhao

Prof. Yifan Zhao

orcid

Research Focus & Metrics

Academic Career Length

7Years (2020-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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25 December 2023 in Advanced Science
Verified
Journal Article
Open access
YHYi‐Wei Hu
Yi‐Wei Hu
YWYuheng Wang
Yuheng Wang
FYFang Yang
Fang Yang
Dingxin LiuDingxin Liu
Dingxin Liu
GLGuang‐Hao Lu
Guang‐Hao Lu
YZYABIN ZHU
YABIN ZHU
Electrical stimulation (ES) is proposed as a therapeutic solution for managing chronic wounds. However, its widespread clinical adoption is limited by the requirement of additional extracorporeal devices to power ES‐based wound dressings. In this study, a novel sandwich‐structured photovoltaic microcurrent hydrogel dressing (PMH dressing) is designed for treating diabetic wounds. This innovative dressing comprises flexible organic photovoltaic (OPV) cells, a flexible micro–electro–mechanical systems (MEMS) electrode, and a multifunctional hydrogel serving as an electrode–tissue interface. The PMH dressing is engineered to administer ES, mimicking the physiological injury current occurring naturally in wounds when exposed to light; thus, facilitating wound healing. In vitro experiments are performed to validate the PMH dressing's exceptional biocompatibility and robust antibacterial properties. In vivo experiments and proteomic analysis reveal that the proposed PMH dressing significantly accelerates the healing of infected diabetic wounds by enhancing extracellular matrix regeneration, eliminating bacteria, regulating inflammatory responses, and modulating vascular functions. Therefore, the PMH dressing is a potent, versatile, and effective solution for diabetic wound care, paving the way for advancements in wireless ES wound dressings.

8 February 2024 in Microsystems & Nanoengineering
Verified
Journal Article
Open access
PDF file
SWSong Wang
Song Wang
Chenying WangChenying Wang
Chenying Wang
YZYifan Zhao
Yifan Zhao
YZYujing Zhang
Yujing Zhang
YZYaxin Zhang
Yaxin Zhang
ZJZhuangde Jiang
Zhuangde Jiang
Stress tolerance plays a vital role in ensuring the effectiveness of piezoresistive sensing films used in flexible pressure sensors. However, existing methods for enhancing stress tolerance employ dome-shaped, wrinkle-shaped, and pyramidal-shaped microstructures in intricate molding and demolding processes, which introduce significant fabrication challenges and limit the sensing performance. To address these shortcomings, this paper presents periodic microslits in a sensing film made of multiwalled carbon nanotubes and polydimethylsiloxane to realize ultrahigh stress tolerance with a theoretical maximum of 2.477 MPa and a sensitivity of 18.092 kPa−1. The periodic microslits permit extensive deformation under high pressure (e.g., 400 kPa) to widen the detection range. Moreover, the periodic microslits also enhance the sensitivity based on simultaneously exhibiting multiple synapses within the sensing interface and between the periodic sensing cells. The proposed solution is verified by experiments using sensors based on the microslit strategy for wind direction detection, robot movement sensing, and human health monitoring. In these experiments, vehicle load detection is achieved for ultrahigh pressure sensing under an ultrahigh pressure of over 400 kPa and a ratio of the contact area to the total area of 32.74%. The results indicate that the proposed microslit strategy can achieve ultrahigh stress tolerance while simplifying the fabrication complexity of preparing microstructure sensing films.

14 February 2025 in Advanced Science
Verified
Journal Article
Open access
MLMujie Liu
Mujie Liu
YWYuheng Wang
Yuheng Wang
HWHaodong Wang
Haodong Wang
LQLihong Qi
Lihong Qi
YSYuxuan Shang
Yuxuan Shang
WWWen Wang
Wen Wang
In this study, an electret‐inspired, charge‐injected hydrogel called QOSP hydrogel (QCS/OD/SDI/PANI/PS/Plasma) that promotes scar‐free healing of bacteria‐infected burns through bioelectrical stimulation and immune modulation, is presented. The hydrogel, composed of quaternized chitosan (QCS), oxidized dextran (OD), sulfadiazine (SDI), polystyrene (PS), and polyaniline nanowires (PANI), forms a conductive network capable of storing and releasing electric charges, emulating an electret‐like mechanism. This structure delivers bioelectrical signals continuously, enhancing wound healing by regulating immune responses and minimizing fibrosis. In a mouse model of second‐degree burns infected with Staphylococcus aureus (SA) and Pseudomonas aeruginosa (PA), the hydrogel accelerates wound healing by 32% and reduces bacterial load by 60%, significantly inhibited scar formation by 40% compared to controls. QOSP hydrogel modulates the Th1/Th2 immune balance toward a Th1‐dominant antifibrotic state through quaternized chitosan, thereby reducing collagen deposition by 35%. Electro‐dielectric characterization reveals a dielectric constant of 6.2, a 34% improvement in conductivity (3.33 × 10−5 S/m) and a 30 °C increase in thermal stability. Proteomic analysis highlights a 50% down‐regulation of pro‐inflammatory and pro‐fibrotic pathways, suggesting a controlled immune response conducive to scar‐free healing. This study underscores the potential of bioelectrically active hydrogels as a novel approach for treating infected wounds prone to scarring.

31 July 2022 in ACS Nano
Verified
Journal Article
Closed access
YLYaojin Li
Yaojin Li
XZXi Zha
Xi Zha
YZYifan Zhao
Yifan Zhao
QLQi Lu
Qi Lu
BLBoyan Li
Boyan Li
MLMing Liu
Ming Liu

17 March 2025 in Microsystems & Nanoengineering
Verified
Journal Article
Open access
PDF file
FHFeng Han
Feng Han
YWYangguang Wu
Yangguang Wu
YZYifan Zhao
Yifan Zhao
WJWeixuan Jing
Weixuan Jing
KZKun Zheng
Kun Zheng
ZJZhuangde Jiang
Zhuangde Jiang
Metal oxides have been extensively investigated in non-enzymatic biosensors for detecting diabetes owing to their electrochemical catalytic properties and excellent stability. However, lower conductivity and catalytic activity are major obstacles to the commercialization of metal oxide-based non-enzymatic glucose sensors. Herein, we present a novel flexible nonenzymatic glucose sensor utilizing graphene fiber (GF)/Au/Ni(OH)2 composite fiber. The integration of GFs enables a significant uptake of sensing molecules due to its expansive surface area and high electron mobility, ultimately resulting in a decrease in the detection limit. Consequently, the incorporation of Ni(OH)2 provides abundant attachment sites by introducing Au atoms, thereby promoting electron migration and enhancing sensitivity and detection limits. An impressive sensitivity (1095.63 µA mM−1 cm−2) within the detection range (5 µM–2.2 mM) of the integrated GF/Au/Ni(OH)2 fiber is achieved, leading to an incredibly low detection limit (0.294 µM). Additionally, the outstanding repeatability, anti-interference properties, and flexibility of the GF/Au/Ni(OH)2 sensors are obtained as well. Our findings offer a novel method for constructing nano embossments on GFs to achieve superior glucose detection capabilities in the field of wearable electronics in the future.

5 January 2022 in Advanced Functional Materials
Verified
Journal Article
Closed access
PDF file
CLChunlei Li
Chunlei Li
YLYaojin Li
Yaojin Li
YZYifan Zhao
Yifan Zhao
YDYujing Du
Yujing Du
MZMeng Zhao
Meng Zhao
ZZZiyao Zhou
Ziyao Zhou