Advanced chronic kidney disease (CKD) stages lead to exacerbated inflammation and oxidative stress. Patients with CKD in stage 5 need renal hemodialysis (HD) to remove toxins and waste products. However, this renal replacement therapy is inefficient in controlling inflammation. Regular curcumin consumption has been shown to reduce inflammation and oxidative stress in subjects with chronic pathologies, suggesting that the daily intake of curcumin may alleviate these conditions in HD patients. This review analyzes the available scientific evidence regarding the effect of curcumin intake on oxidative stress and inflammation in HD patients, focusing on the mechanisms and consequences of HD and curcumin consumption. The inclusion of curcumin as a dietary therapeutic supplement in HD patients has shown to control the inflammation status. However, the optimal dose and oral vehicle for curcumin administration are yet to be determined. It is important to consider studies on curcumin bioaccessibility to design effective oral administration vehicles. This information will contribute to the achievement of future nutritional interventions that validate the efficacy of curcumin supplementation as part of diet therapy in HD.

Cardiorenal syndrome (CRS) is a multifactorial clinical condition characterized by the bidirectional deterioration of cardiac and renal function, driven by mechanisms such as renin–angiotensin–aldosterone system (RAAS) overactivation, systemic inflammation, oxidative stress, endothelial dysfunction, and fibrosis. The aim of this narrative review is to explore the key molecular pathways involved in CRS and to highlight emerging therapeutic approaches, with a special emphasis on nutritional interventions. We examined recent evidence on the contribution of mitochondrial dysfunction, uremic toxins, and immune activation to CRS progression and assessed the role of dietary and micronutrient factors. Results indicate that a high dietary intake of sodium, phosphorus additives, and processed foods is associated with volume overload, vascular damage, and inflammation, whereas deficiencies in potassium, magnesium, and vitamin D correlate with worse clinical outcomes. Anti-inflammatory and antioxidant bioactives, such as omega-3 PUFAs, curcumin, and anthocyanins from maqui, demonstrate potential to modulate key CRS mechanisms, including the nuclear factor kappa B (NF-κB) pathway and the NLRP3 inflammasome. Gene therapy approaches targeting endothelial nitric oxide synthase (eNOS) and transforming growth factor-beta (TGF-β) signaling are also discussed. An integrative approach combining pharmacological RAAS modulation with personalized medical nutrition therapy and anti-inflammatory nutrients may offer a promising strategy to prevent or delay CRS progression and improve patient outcomes.

Background/Objectives: Chronic kidney disease (CKD) is a progressive pathology, with high global prevalence, associated with inflammation and oxidative stress. Given the limited capacity of conventional treatments to reverse renal damage, complementary alternatives have emerged such as supplementation with anthocyanins from maqui (Aristotelia chilensis), known for their antioxidant and anti-inflammatory properties. This review analyzes the evidence for their impact on CKD progression. Methods: A narrative review of the experimental literature regarding maqui anthocyanins, their bioavailability, and their effects on oxidative stress, inflammation, and CKD to January 2025 was conducted. Articles without peer review or without a focus on Aristotelia chilensis were excluded, guaranteeing an updated compilation on its nephroprotective potential. Results: Anthocyanins have shown benefits in reducing oxidative stress, inflammation, and glycemia regulation. Preclinical studies suggest improvements in renal function as well as less fibrosis. Human trials indicate positive effects on metabolism, although evidence in CKD patients is limited. Bioavailability remains a challenge to optimizing efficacy. Conclusions: Maqui is a promising source of anthocyanins, with nephroprotective potential. However, robust clinical studies are required to determine its safety, optimal dose, and long-term impact in CKD. Its incorporation into evidence-based therapeutic strategies could offer an innovative approach in the management of this disease. More clinical studies are needed to validate the preclinical findings and optimize the therapeutic use of maqui in CKD.

Maqui (Aristotelia chilensis) is a berry native to southern Chile, recognized for its high content of phenolic compounds, particularly delphinidin-type anthocyanins, which confer strong antioxidant and anti-inflammatory properties and have generated growing interest as a functional food. Its scientific relevance has increased due to advances in understanding its biological mechanisms, including the Nrf2 signaling pathway, modulation of systemic inflammation, improvement in mitochondrial function, and potential applications in cardiometabolic, renal, and vascular health. Objective: The objective of this study is to analyze the available evidence on maqui in relation to its nutritional composition, bioactive profile, antioxidant and anti-inflammatory mechanisms, bioavailability, and emerging clinical applications in the prevention and/or treatment of chronic non-communicable diseases. Main findings: Maqui is rich in delphinidins, dietary fiber, and antioxidant micronutrients and modulates key oxidative stress and inflammatory pathways, including Nrf2-HO-1 and NF-κB. Preclinical and early clinical evidence supports its cardiometabolic and nephroprotective effects, with improvements in glycemic control, lipid metabolism, oxidative stress, and endothelial function. Conclusions: Maqui shows considerable potential as a Chilean functional food with antioxidant and anti-inflammatory effects relevant to human health. However, robust clinical trials and formulations with enhanced bioavailability are required to consolidate its therapeutic application.

Uno de los objetivos de la enseñanza tutorial en la carrera de Nutrición y Dietética, es proporcionar a los estudiantes un espacio de aprendizaje para desarrollar habilidades clínicas y competencias profesionales. El propósito del estudio fue evaluar un programa de capacitación en tutoría clínica dirigido a tutores clínicos nutricionistas y su efecto en las percepciones de los estudiantes de práctica clínica y su desempeño profesional. Se desarrolló una intervención antes y después de capacitación en tutoría clínica en nutrición, con una muestra no probabilística (n=8 nutricionistas tutores clínicos; n=‘6 estudiantes). Se hizo un análisis cualitativo de codificación temática y se contrastaron las calificaciones obtenidas mediante T Student. Una vez realizada la intervención los docentes adquirieron herramientas para conducir la tutoría clínica y los estudiantes tuvieron mejores experiencias clínicas. Si bien, el rendimiento académico no mejoró (5,9±0,3; v/s 6,’±0,4; p= 0,4), los docentes percibieron mejoría en el aprendizaje. Se puede concluir que la formación de nutricionistas competentes, responsables de brindar bienestar y cuidado integral a los pacientes depende de la excelencia en la formación del cuerpo docente, que sea centrada en el estudiante y con una enseñanza de calidad que promueva el aprendizaje efectivo.

Background/Objectives: Chronic kidney disease (CKD) is one of the fastest-growing non-communicable diseases globally, with a disproportionate burden in populations undergoing rapid dietary and epidemiological transitions. Beyond traditional clinical risk factors, increasing evidence from nutritional epidemiology suggests that contemporary dietary environments may play a significant role in shaping CKD risk, complications, and progression. This narrative review examines CKD as a potential unintended consequence of global dietary transitions, with particular emphasis on ultra-processed foods and overall diet quality. Methods: A structured narrative review was conducted using evidence from prospective cohort studies, systematic reviews, meta-analyses, and mechanistic research. Findings were synthesized within a population-health framework integrating dietary patterns, food processing classification, and biologically plausible pathways relevant to kidney health. Results: Healthier dietary patterns, including Mediterranean, DASH, and plant-forward diets, are consistently associated with lower risk of incident CKD, slower kidney function decline, and reduced mortality. In contrast, Western dietary patterns characterized by high intake of ultra-processed foods are linked to increased CKD risk and adverse cardiometabolic outcomes. Beyond mediators such as hypertension, diabetes, and obesity, emerging mechanisms include dietary acid load, gut dysbiosis and uremic toxin production, sodium density, and exposure to highly bioavailable phosphate additives. Conclusions: Dietary transitions toward ultra-processed, low-fiber, sodium- and additive-rich food environments may contribute to the growing global burden of CKD through interconnected metabolic, inflammatory, and gut–kidney pathways. Improving diet quality and addressing food processing at the population level represent promising opportunities for CKD prevention and risk reduction.