For civil protection reasons there is a strong need to improve the inventory of areas that are more vulnerable to earthquake ground motions or to earthquake-related secondary effects, such as landslides, liquefaction or soil amplifications. The use of remote sensing and Geographic Information Systems (GIS) methods along with the related geo-databases can assist local and national authorities to be better prepared and organized. Remote sensing and GIS techniques are investigated in north-eastern Greece in order to contribute to the systematic, standardized inventory of those areas that are more susceptible to earthquake ground motions, to earthquake-related secondary effects and to tsunami-waves. Knowing areas with aggregated occurrence of causal (“negative”) factors influencing earthquake shock and, thus, the damage intensity, this knowledge can be integrated into disaster preparedness and mitigation measurements. The evaluation of satellite imageries, digital topographic data and open source geodata contributes to the acquisition of the specific tectonic, geologic and geomorphologic settings influencing local site conditions in an area and, thus, estimate possible damage to be suffered.