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Dr. Asolina Braun
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16Years (2011-Present)
(Calculated once Scilit publication data is synced: current year − year of first publication + 1)
Representative Publications
View All Publications22 April 2016 in Science
Journal Article
LMLaura K. Mackay
Laura K. MackayMMMartina Minnich
Martina Minnich
NKNatasja A. M. Kragten
Natasja A. M. Kragten
YLYang Liao
Yang Liao
BNBenjamin Nota
Benjamin Nota
Klaas van Gisbergen +19
Transcription factors define tissue T cells: The immune system fights microbial invaders by maintaining multiple lines of defense. For instance, specialized memory T cells [resident memory T cells (T rms )] colonize portals of pathogen entry, such as the skin, lung, and gut, to quickly halt reinfections. Mackay et al. now report that in mice, T rms as well as other tissue-dwelling lymphocyte populations such as natural killer cells share a common transcriptional program driven by the related transcription factors Hobit and Blimp1. Tissue residency and retention of lymphocytes require expression of Hobit and Blimp1, which, among other functions, suppress genes that promote tissue exit. Science , this issue p. 459
1 December 2015 in Immunity
Journal Article
LMLaura K. Mackay
Laura K. MackayEWErica Wynne-Jones
Erica Wynne-JonesDFDavid Freestone
David Freestone
DPDaniel G. Pellicci
Daniel G. PellicciLMLisa A. Mielke
Lisa A. MielkeFCFrancis R. Carbone
Francis R. Carbone
+5
1 March 2015 in The Journal of Immunology
Journal Article
LMLaura K. Mackay
Laura K. MackayABAsolina Braun
Asolina BraunBMBethany L. Macleod
Bethany L. Macleod
NCNicholas Collins
Nicholas Collins
CTChristina Tebartz
Christina Tebartz
TGThomas Gebhardt
Thomas Gebhardt +2
Tissue-resident memory T cells provide local immune protection in barrier tissues, such as skin and mucosa. However, the molecular mechanisms controlling effector T cell retention and subsequent memory formation in those locations are not fully understood. In this study, we analyzed the role of CD69, an early leukocyte activation marker, in regulating effector T cell egress from peripheral tissues. We provide evidence that CD69 surface expression by skin-infiltrating CD8 T cells can be regulated at multiple levels, including local Ag stimulation and signaling through type I IFNRs, and it coincides with the transcriptional downregulation of the sphingosine-1-phosphate receptor S1P1. Importantly, we demonstrate that expression of CD69, by interfering with sphingosine-1-phosphate receptor function, is a critical determinant of prolonged T cell retention and local memory formation. Our results define an important step in the generation of long-lived adaptive immune memory at body surfaces.
1 October 2016 in Immunity
Journal Article
Daniel Fernandez RuizWNWei Yi Ng
Wei Yi Ng
LHLauren E. Holz
Lauren E. HolzJMJoel Z. Ma
Joel Z. MaAZAli Zaid
Ali ZaidWHWilliam Ross Heath
William Ross Heath +27
14 August 2011 in Nature Immunology
Journal Article
ABAsolina Braun
Asolina BraunTWTim Worbs
Tim WorbsGMG Leandros Moschovakis
G Leandros Moschovakis
SHStephan Halle
Stephan HalleKHKatharina Hoffmann
Katharina Hoffmann
RDReinhold Förster; Dr.
Reinhold Förster; Dr. +2
24 March 2014 in Proceedings of the National Academy of Sciences
Journal Article
AZAli Zaid
Ali ZaidLMLaura K. Mackay
Laura K. MackayARAzad Rahimpour
Azad Rahimpour
ABAsolina Braun
Asolina BraunMVMarc Veldhoen
Marc VeldhoenSMScott N. Mueller
Scott N. Mueller +3
Significance: Tissue-resident memory T cells (T RM ) form in the skin where they are retained and can protect against subsequent infection. Using a combination of intravital imaging and mathematical modeling of skin T RM that form after cutaneous herpes simplex virus 1 infection, we reveal that these memory T cells persist at the site of infection for the life of a mouse owing to slow random migration. We also report that T RM compete with dendritic epidermal γδ T cells in skin for local survival signals, suggesting that T cells compete for space within an epidermal niche.
About Me
Dr. Asolina Braun studied biology and pursued a doctoral degree at Hannover Medical School in Germany with Reinhold Förster and Tim Worbs. Here, she employed a novel micro-surgical procedure of intralymphatic injection together with multi-photon microscopy to study chemokine-driven migration of lymph-derived immune cells. A fellowship from the German Research Foundation enabled her to undertake post-doctoral studies with Francis Carbone and Thomas Gebhardt which focused on how cytokines enable the retention and differentiation of tissue-resident memory T cells (TRM) in extra-lymphoid tissues, particularly skin. During this time, she has contributed to the field by defining survival factors and differentiation signals for TRM and developed a strong interest in skin immunology. In 2018, she joined Tony Purcell at Monash University to study antigen presentation in psoriasis. She continues to work on skin immune responses in the context of psoriasis as a group leader at Monash University. This work strives to develop novel therapeutic avenues of tolerance induction in autoinflammatory skin diseases.