Depressive disorder (DD) and generalized anxiety disorder (GAD), two prominent mental health conditions, are commonly diagnosed using subjective methods such as scales and interviews. Previous research indicated that machine learning (ML) can enhance our understanding of their underlying mechanisms. This study seeks to investigate the mechanisms of DD, GAD, and healthy controls (HC) while constructing a diagnostic framework for triple classifications. Specifically, the experiment involved collecting electroencephalogram (EEG) signals from 42 DD patients, 45 GAD patients, and 38 HC adults. The Phase Lag Index (PLI) was employed to quantify brain functional connectivity and analyze differences in functional connectivity among three groups. This study also explored the impact of time window feature computations on classification performance, including the XGBoost, CatBoost, LightGBM, and ensemble models. In order to enhance classification performance, a feature optimization algorithm based on Autogluon-Tabular was proposed. The results indicate that a 12 s time window provides optimal classification performance for the three groups, achieving the highest accuracy of 97.33% with the ensemble model. The analysis further reveals a significant reorganization of the brain, with the most pronounced changes observed in the frontal lobe and beta rhythm. These findings support the hypothesis of abnormal brain functional connectivity in DD and GAD, contributing valuable insights into the neural mechanisms underlying DD and GAD.

Current assessments for generalized anxiety disorder (GAD) are often subjective and do not rely on a standardized measure to evaluate the GAD across its severity levels. The lack of objective and multi-level quantitative diagnostic criteria poses as a significant challenge for individualized treatment strategies. To address this need, this study aims to establish a GAD grading and quantification diagnostic model by integrating an electroencephalogram (EEG) and ensemble learning. In this context, a total of 39 normal subjects and 80 GAD patients were recruited and divided into four groups: normal control, mild GAD, moderate GAD, and severe GAD. Ten minutes resting state EEG data were collected for every subject. Functional connectivity features were extracted from each EEG segment with different time windows. Then, ensemble learning was employed for GAD classification studies and brain mechanism analysis. Hence, the results showed that the Catboost model with a 10 s time window achieved an impressive 98.1% accuracy for four-level classification. Particularly, it was found that those functional connections situated between the frontal and temporal lobes were significantly more abundant than in other regions, with the beta rhythm being the most prominent. The analysis framework and findings of this study provide substantial evidence for the applications of artificial intelligence in the clinical diagnosis of GAD.

Objective. Recent technological advances show the feasibility of fusing surface electromyography (sEMG) signals and movement data to predict lower limb ambulation intentions. However, since the invasive fusion of different signals is a major impediment to improving predictive performance, searching for a non-invasive (NI) fusion mechanism for lower limb ambulation pattern recognition based on different modal features is crucial. Approach . We propose an end-to-end sequence prediction model with NI dual attention temporal convolutional networks (NIDA-TCNs) as a core to elegantly address the essential deficiencies of traditional decision models with heterogeneous signal fusion. Notably, the NIDA-TCN is a weighted fusion of sEMG and inertial measurement units with time-dependent effective hidden information in the temporal and channel dimensions using TCN and self-attentive mechanisms. The new model can better discriminate between walking, jumping, downstairs, and upstairs four lower limb activities of daily living. Main results . The results of this study show that the NIDA-TCN models produce predictions that significantly outperform both frame-wise and TCN models in terms of accuracy, sensitivity, precision, F1 score, and stability. Particularly, the NIDA-TCN with sequence decision fusion (NIDA-TCN-SDF) models, have maximum accuracy and stability increments of 3.37% and 4.95% relative to the frame-wise model, respectively, without manual feature-encoding and complex model parameters. Significance . It is concluded that the results demonstrate the validity and feasibility of the NIDA-TCN-SDF models to ensure the prediction of daily lower limb ambulation activities, paving the way to the development of fused heterogeneous signal decoding with better prediction performance.

The emergence of modern prosthetics controlled by bio-signals has been facilitated by AI and microchip technology innovations. AI algorithms are trained using sEMG produced by muscles during contractions. The data acquisition procedure may result in discomfort and fatigue, particularly for amputees. Furthermore, prosthetic companies restrict sEMG signal exchange, limiting data-driven research and reproducibility. GANs present a viable solution to the aforementioned concerns. GANs can generate high-quality sEMG, which can be utilised for data augmentation, decrease the training time required by prosthetic users, enhance classification accuracy and ensure research reproducibility. This research proposes the utilisation of a one-dimensional deep convolutional GAN (1DDCGAN) to generate the sEMG of hand gestures. This approach involves the incorporation of dynamic time wrapping, fast Fourier transform and wavelets as discriminator inputs. Two datasets were utilised to validate the methodology, where five windows and increments were utilised to extract features to evaluate the synthesised sEMG quality. In addition to the traditional classification and augmentation metrics, two novel metrics—the Mantel test and the classifier two-sample test—were used for evaluation. The 1DDCGAN preserved the inter-feature correlations and generated high-quality signals, which resembled the original data. Additionally, the classification accuracy improved by an average of 1.21–5%.