Over the last 20 years, the tourism-climate change nexus has emerged as a policy and research issue, animating a polarized debate between climate mitigation and adaptation for the sector. While the position of tourism with respect to its contribution to climate change and decarbonization requirements are clearly acknowledged by both scientific community and governments, a place-specific, risk-informed planning for climate change adaptation becomes increasingly pressing. It is even more urgent for rural areas, that envision cultural tourism-driven strategies as a sustainable pathway for economic and social regeneration. They are strongly threatened by rapid and intensifying climate change impacts, loss of biodiversity and environmental pressures on their cultural and natural values, and compared to urban areas, they are not yet equipped to respond effectively, and their socio-economic conditions are often aggravated by short-term management decisions, lack of institutional support, inadequate policy implementation efforts and low public awareness. So far, the impacts of climate change on tourism have been investigated through various methodological approaches, mostly focused on forecasting climatic changes and analyzing how they would modify global tourism flows. These approaches resulted in a lack of appropriate contextualization of climate risk in tourism destinations, and the consequences of multiple climate-related hazards interacting with environmental, economic, social, cultural and political factors at local scale are often neglected. Consequently, destinations apply short-term, unsustainable coping strategies and individual adjustments to climate variability and related alterations in tourism demand-supply patterns, rather than pursuing a more strategic and long-term climate change adaptation. The study proposes a conceptual and methodological framework aimed at performing a spatially explicit multi-hazard risk assessment, and it combines data-based and community-based approaches involving local stakeholders in assessing climate risk and co-designing tailored adaptive solutions to be implemented at destination scale. It builds on the acknowledgement that spatial planning can support an effective, future-oriented climate change adaptation for cultural tourism, and act as an information-based instrument for coordinating different activities and transformation patterns over the territory, as well as a mechanism for the implementation of adaptation measures on the ground. This perspective has been strengthened through a case study implementation, which involved six small historical villages in the Fiastra Valley, an inner rural area in the Province of Macerata, Marche region, Italy. Here, participatory planning and community-based action research have been tested, proving the value of engaging diverse actors of society in mutual learning and co-creation of innovative knowledge. In that sense, transdisciplinary research represents a powerful way for tackling complex challenges, where territorial planning can bring together multiple fields – climate change adaptation, risk management, rural regeneration, cultural tourism planning, landscape management. Such models of place-based understanding can better boost transitions to sustainability, by bridging science–policy–society divide and supporting scientific evidence for policy, from scientists to policymakers.