Off-label use of semaglutide for non-diabetic weight loss (which regulators have linked to social media promotion) created worldwide supply shortages. We evaluated worldwide semaglutide interest measured by online search behavior to gauge social media and conventional print media reporting’s effect on search interest. Using Google Trends Extended for Health (GTEH) multiple sampling, we retrieved regional online interest (ROI) for all countries and extracted timelines and top search queries for January 2021–August 2023 for countries with median ROI ≥ 20 using the “semaglutide” topic. We obtained semaglutide media reporting from the ProQuest database. We estimated the effect of media and within-country semaglutide interest on between-country interest with Granger causality analysis. We determined changepoints for trends within each country with joinpoint regression. We determined prominent themes in search queries for each country with natural language processing thematic analysis. Twenty-seven countries were included. Most countries showed an increase in semaglutide interest over time, with Canada and the USA showing the largest sustained interest. Most of the search interest arose from 2022 onwards. Granger’s analysis showed that media coverage could only partially explain interest, and interest in some countries partially preceded interest in others, with the UK and Germany showing strong relationships between news reports and lagged search interest. Joinpoint analysis identified up to four significant within-country changepoints. Most countries showed significant positive weekly trends in 2021–2022, although uptrends in search interest varied considerably between countries. One episode of the Dr. Oz show (TV media event) coincided with strong peaks in numerous countries. Natural language processing of top search queries showed some agreement between countries and country-specific themes. Weight loss was a major theme in most countries, while a diabetes theme was generally absent or weak. Some countries (Australia, Chile, South Africa, UK) had themes for buying Ozempic from (named) local retailers, and Germany had a theme related to buying Ozempic without a script. GTEH data provided insights into global search interest in semaglutide and regional variation. Studies focusing on specific countries which include social media data can elucidate specific drivers behind the surge in off-label use of semaglutide.

Curationis provides a forum for cutting-edge theories and research models related to the exploration of issues experienced and the best practices of nurses and midwives so as to improve nursing education, nursing administration and community nursing within Africa.

The rising prevalence of obesity and excessive adiposity are global public health concerns. Understanding determinants of changes in adiposity over time is critical for informing effective evidence-based prevention or treatment. However, limited information is available to achieve this objective. Cultural, demographic, environmental, and behavioral factors including socio-economic status (SES) likely account for obesity development. To this end, we related these variables to anthropometric measures in 1058 black adult Tswana-speaking South Africans who were HIV negative in a prospective study over five years. Body mass index (BMI) and waist circumference increased in both sexes, whereas triceps skinfold thickness remained the same. Over the five years, women moved to higher BMI categories and more were diagnosed with central obesity. Age correlated negatively, whereas SES, physical activity, energy, and fat intake correlated positively with adiposity markers in women. In men, SES, marital status, physical activity, and being urban predicted increases in adiposity. For women, SES and urbanicity increased, whereas menopause and smoking decreased adiposity. Among men, smokers had less change in BMI than those that never smoked over five years. Our findings suggest that interventions, focusing on the urban living, the married and those with the highest SES—the high-risk groups identified herein—are of primary importance to contain morbidity and premature mortality due to obesity in black South Africans.

In an ever-increasingly online world, many Internet users seek information from online search engines such as Google. Accessing such search activity allows infodemiologists a glimpse into the collective online mind. Tools such as Google Trends and Google Health Trends (GHT) can be used to gauge search activity in key geographical regions and for specific periods of time. Recently, Google implemented changes to the GHT platform. Evidence is provided here for an initial exploration of how this change impacted the data obtained from GHT. Comparing 177 weekly probabilities for short search sessions of 421 Freebase IDs in thirty geographies extracted from GHT both before and after the implemented change, a low correlation (median of all Spearman ρ = 0.262 [IQR 0.04; 0.53]) between these data was observed for the year 2022. In general, the extracted values are higher after the implemented changes, compared to the values extracted before the change. Future research using the GHT API should not attribute increases in GHT data from 1 January 2022 onward as being reflective of increased search activity for a specific keyword, but rather attribute it to the implemented change to the GHT sampling strategy.

The COVID-19 pandemic challenged the status quo of higher education practices. With the transition to remote learning, students and faculty faced several challenges while making great strides in equalizing education access. Although theoretical aspects can be easily taught online, practical experiences are difficult to convey without dedicated laboratories and equipment. This is especially true in biological studies, where practical laboratory training significantly impacts the Student’s professional development. Presented here is an overview of some of the available resources that faculty can implement in their remote teaching curricula, a discussion on a possible approach toward creating in silico practicums, and potential challenges that could be experienced in creating such virtual laboratories (VL). To prevent another interruption in academic training, higher education institutions (HEIs) should focus on designing, developing, and implementing practical educational material. We propose that these resources be free and open-source, allowing for a global effort to create a standardized practical curriculum for basic biological technical skills.