The field of wireless communication has undergone revolutionary changes driven by technological advancements in recent years. Central to this evolution is wireless ad hoc networks, which are characterized by their decentralized nature and have introduced numerous possibilities and challenges for researchers. Moreover, most of the existing Internet of Things (IoT) networks are based on ad hoc networks. This study focuses on the exploration of interference management and Medium Access Control (MAC) schemes. Through statistical derivations and systematic simulations, we evaluate the efficacy of guard zone-based MAC protocols under Rayleigh fading channel conditions. By establishing a link between network parameters, interference patterns, and MAC effectiveness, this work contributes to optimizing network performance. A key aspect of this study is the investigation of optimal guard zone parameters, which are crucial for interference mitigation. The adaptive guard zone scheme demonstrates superior performance compared to the widely recognized Carrier Sense Multiple Access (CSMA) and the system-wide fixed guard zone protocol under fading channel conditions that mimic real-world scenarios. Additionally, simulations reveal the interactions between network variables such as node density, path loss exponent, outage probability, and spreading gain, providing insights into their impact on aggregated interference and guard zone effectiveness.