The aim of this study was to demonstrate the absolute necessity of control experiments for a correct interpretation of mercury drop test results when applied to mechanistic studies of palladacycle-catalyzed reactions. It was shown that the interaction of diverse azapalladacycles with metallic mercury leads to the formation of organomercuric chlorides during the redox-transmetalation process. The structure of these organomercurials was confirmed by elemental analysis, ¹H, ¹³C{¹H}, and ¹⁹⁹Hg{¹H} NMR spectra, X-ray diffraction analysis, and DFT calculations. The behavior and properties of C,N-mercuracycles bearing the weak and labile N···Hg bond are discussed on the basis of the temperature dependence of the NMR spectra and calculated thermodynamic parameters of the dechelation process.

Indoles and hydantoins are important heterocycles scaffolds which present in numerous bioactive compounds which possess various biological activities. Moreover, they are essential building blocks in organic synthesis, particularly for the preparation of important hybrid molecules. The series of hybrid compounds containing indoles and imidazolidin-2-one moiety with direct C–C bond were synthesized using an amidoalkylation one-pot reaction. All compounds were investigated as a growth regulator for germination, growth and development of wheat seeds (Triticum aestivum L). Their effect on drought resistance at very low concentrations (4 × 10⁻⁵ M) was evaluated. The study highlighted identified the leading compounds, 3a and 3e, with higher growth-regulating activity than the indole-auxin analogues.

The biodistribution of PLGA nanoparticles labelled with Pd in the form of a dimeric cyclopalladated derivative of N , N -dimethyldiphenylmethylamine was investigated in rats using graphite furnace atomic absorption spectrometry and inductively coupled plasma mass spectrometry.

Ureas, carbamates and oxamates are rather common structural motifs. They are present in both natural and synthetic compounds that exhibit a wide spectrum of biological activity. These derivatives of carbonic and oxalic acids are regularly employed as the basic structural elements in hybrid molecule synthesis, as well as in organic synthesis in general. A series of unsymmetrical hybrid compounds (E1–E4) has been synthesized, with core imidazolidin-2-one and aryl moieties as urea and carbamate derivatives. Plant growth regulatory activity of these compounds was studied with respect to their influence on germination, growth and development of wheat (Triticum aestivum L.) seeds in laboratory and field tests. Their effect on drought resistance concentrations as low as 4 × 10⁻⁷ M was established. Compounds E1 and E4 have shown higher growth-regulating activity than standard thidiazuron and CCC.

The functionalized derivatives of heterocyclic compounds find extensive application in medicine, agriculture, and many fields of chemistry as precursors for more complex products that display remarkable biological and catalytic activities. A whole range of different heterocycles can be obtained by intra- or intermolecular amidoalkylation. This review presents the examples of successful application of the reactions of C-amidoalkylation, in particular, enantioselective reactions for the modification of heterocycles and outlines the prospects of their further application.