As two practical and important image processing tasks, color demosaicking (CDM) and super-resolution (SR) have been studied for decades. However, most literature studies these two tasks independently, ignoring the potential benefits of a joint solution. In this paper, aiming at efficient and effective joint demosaicking and super-resolution (JDSR), a well-designed two-stage convolutional neural network (CNN) architecture is proposed. For the first stage, by making use of the sampling-pattern information, a pattern-aware feature extraction (PFE) module extracts features directly from the Bayer-sampled low-resolution (LR) image, while keeping the resolution of the extracted features the same as the input. For the second stage, a dual-branch feature refinement (DFR) module effectively decomposes the features into two components with different spatial frequencies, on which different learning strategies are applied. On each branch of the DFR module, the feature refinement unit, namely, densely-connected dual-path enhancement blocks (DDEB), establishes a sophisticated nonlinear mapping from the LR space to the high-resolution (HR) space. To achieve strong representational power, two paths of transformations and the channel attention mechanism are adopted in DDEB. Extensive experiments demonstrate that the proposed method is superior to the sequential combination of state-of-the-art (SOTA) CDM and SR methods. Moreover, with much smaller model size, our approach also surpasses other SOTA JDSR methods.

Oral squamous cell carcinoma (OSCC) has the characteristics of early regional lymph node metastasis. OSCC patients often have poor prognoses and low survival rates due to cervical lymph metastases. Therefore, it is necessary to rely on a reasonable screening method to quickly judge the cervical lymph metastastic condition of OSCC patients and develop appropriate treatment plans. In this study, the widely used pathological sections with hematoxylin-eosin (H&E) staining are taken as the target, and combined with the advantages of hyperspectral imaging technology, a novel diagnostic method for identifying OSCC lymph node metastases is proposed. The method consists of a learning stage and a decision-making stage, focusing on cancer and non-cancer nuclei, gradually completing the lesions' segmentation from coarse to fine, and achieving high accuracy. In the learning stage, the proposed feature distillation-Net (FD-Net) network is developed to segment the cancerous and non-cancerous nuclei. In the decision-making stage, the segmentation results are post-processed, and the lesions are effectively distinguished based on the prior. Experimental results demonstrate that the proposed FD-Net is very competitive in the OSCC hyperspectral medical image segmentation task. The proposed FD-Net method performs best on the seven segmentation evaluation indicators: MIoU, OA, AA, SE, CSI, GDR, and DICE. Among these seven evaluation indicators, the proposed FD-Net method is 1.75%, 1.27%, 0.35%, 1.9%, 0.88%, 4.45%, and 1.98% higher than the DeepLab V3 method, which ranks second in performance, respectively. In addition, the proposed diagnosis method of OSCC lymph node metastasis can effectively assist pathologists in disease screening and reduce the workload of pathologists. Source codes will be released at https://github.com/MrXueyuZhang/FD-Net .