Marius Constantin Moraru

Dr. Marius Constantin Moraru

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Research Focus & Metrics

Academic Career Length

3Years (2024-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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Verified
Journal Article
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ANAlin Horatiu Nedelcu
Alin Horatiu Nedelcu
ALAncuta Lupu
Ancuta Lupu
MMMarius Constantin Moraru
Marius Constantin Moraru
CTClaudia Cristina Tarniceriu
Claudia Cristina Tarniceriu
CSCristinel Ionel Stan
Cristinel Ionel Stan
VLVasile Valeriu Lupu
Vasile Valeriu Lupu
Background: The aberrant origin of the right subclavian artery (ARSA), also known as the lusoria artery, is a congenital malformation with an incidence of 0.5–4.4%. Most cases are incidental due to minimal clinical manifestations. Computer tomography (CT) is important in diagnosing and evaluating these patients. Materials and Methods: We conduct a computerized search in two databases, PubMed and EMBASE, for articles published between 1 January 2022 and 31 December 2023, PROSPERO code: CRD42024511791. Eligible for inclusion were case reports and case series that presented the aberrant origin of the right subclavian artery. The main outcome was the highlighting of the morphological types of ARSA. In this context, we proposed a new classification system of this anomaly. The secondary outcome was the evaluation of the demographic distribution of the lusoria artery. Results: Our search identified 47 articles describing 51 patients with ARSA. The typical course for ARSA is retroesophageal, being registered in 49 out of 51 patients. This malformation is frequently associated with Kommerell diverticulum (15 out of 51), troncus bicaroticus (7 out of 51), and aberrant origins of the right vertebral artery (7 out of 51). We observed a higher incidence of the condition among women (32 out of 51) compared to men (19 out of 51). From a demographic point of view, ARSA is more frequent in the “44 to 57 years” and “58 to 71 years” age ranges. Conclusions: ARSA is a congenital malformation resulting from a defect in the development of the aortic arches. The imaging studies such as computer tomography play a defined diagnostic role.

Verified
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Andreea RotunduAndreea Rotundu
Andreea Rotundu
ANAlin Horatiu Nedelcu
Alin Horatiu Nedelcu
RTRazvan Tudor Tepordei
Razvan Tudor Tepordei
MMMarius Constantin Moraru
Marius Constantin Moraru
DCDragos Andrei Chiran
Dragos Andrei Chiran
MLMaria Magdalena Leon
Maria Magdalena Leon
(1) Background: The aortic arch (AA) branching model is challenging, considering the multiple anatomical variations documented in existing research. The bovine aortic arch (BAA) is the most prevalent anatomical variation among these. This variant of AA branching has long been considered a nonsymptomatic malformation, having been discovered incidentally during imaging investigations for other causes. However, more recent studies have demonstrated that BAA shows a frequent association with coarctation of the aorta (CoA), thoracic aortic disease (TAD), and stroke. At the same time, given the current context of increasing activity in the fields of interventional and surgical procedures in the aorta and its branches, it is very important to know the medical–surgical implications of this anatomical variant. (2) Methods: We conducted a comprehensive review using PubMed and Embase, focusing specifically on randomized trials and cohort analyses that examined the medical–surgical implications of BAA. We assessed information related to studied groups, medical procedures, and study outcomes. Initially, we identified 8454 studies, and after rigorous evaluation, we narrowed down our review to 25 articles. (3) Discussions: The intervention consisted of assessing the risks associated with BAA through different imaging investigation methods such as computer tomographic angiography (CTA), magnetic resonance imaging (MRI), or ultrasonography (US). The following results were evaluated: the prevalence of the BAA, the importance of imaging investigations in establishing the diagnosis and the therapeutic management and monitoring the evolution of patients with the BAA, the association of the BAA with CoA, TAD, and stroke, and the potential risks of interventional treatment in patients with the BAA. (4) Conclusions: The prevalence of the BAA differs both between different ethnic groups and between genders. Advanced imaging methods such as CTA and 4D flow MRI allow detailed descriptions of supra-aortic vascular anatomy and information about blood flow velocities, direction, and turbulence in the AA. US remains an easy and valuable imaging investigation, with the potential to detect and correctly diagnose the BAA and its hemodynamic implications. Anatomical variations in the AA are associated with increased rates of TAD, CoA, and stroke, necessitating early diagnosis and increased supervision of patients with such incidentally observed abnormalities. In addition, there is a need to further develop and refine the surgical techniques used and personalize them to the individual characteristics of patients with the BAA.

27 June 2025 in Nutrients
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FAFawzy Akad
Fawzy Akad
CSCristinel Ionel Stan
Cristinel Ionel Stan
FZFlorin Zugun-Eloae
Florin Zugun-Eloae
SPSorin Nicolae Peiu
Sorin Nicolae Peiu
NANada Akad
Nada Akad
VMVeronica Mocanu
Veronica Mocanu
Gastric cancer remains a significant global health burden, with curative treatment relying on surgical resection, typically total or subtotal gastrectomy. However, the procedure frequently triggers acute metabolic and nutritional disturbances that may impact recovery. Objective: This prospective study aimed to investigate whether the type of gastrectomy (total vs. subtotal) influences early postoperative biochemical and hematological alterations, with particular attention to nutritional impact. Methods: A cohort of 295 patients (123 female, 172 male) who underwent gastrectomy for gastric cancer at the Institute of Oncology Iași (2023–2024) was evaluated. Laboratory parameters, including hemoglobin, hematocrit, lymphocyte and platelet counts, serum albumin, total protein, sodium, potassium, creatinine, and urea, were analyzed preoperatively and on postoperative day 14 using standard clinical methods. Results: Anemia was observed in over 90% of patients, irrespective of sex or procedure type. Electrolyte imbalances (notably hyponatremia and hypokalemia) and indicators of nutritional deficit (hypoalbuminemia, low creatinine) were highly prevalent, with a greater frequency among female patients. Total gastrectomy was associated with more severe biochemical and nutritional alterations compared to subtotal procedures. Conclusions: Total gastrectomy significantly exacerbates early postoperative metabolic and nutritional derangements. These findings reinforce the need for proactive, personalized postoperative nutritional and electrolyte management strategies to support recovery and reduce complication risks.

14 November 2024 in Medicina
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Journal Article
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ANAlin Horatiu Nedelcu
Alin Horatiu Nedelcu
RTRazvan Tudor Tepordei
Razvan Tudor Tepordei
ALAncuta Lupu
Ancuta Lupu
VLVasile Valeriu Lupu
Vasile Valeriu Lupu
MMMarius Constantin Moraru
Marius Constantin Moraru
CTClaudia Cristina Tarniceriu
Claudia Cristina Tarniceriu
Background and Objectives: Haller Cells (HCs) represent the abnormal migration of ethmoid cells that are located below the ethmoid bulla at the level of the upper wall of the maxillary sinus. Through their placement, the cells can exert a mass effect on the infundibulum of the maxillary sinus. The aim of our study is to investigate the prevalence of Haller cells in the Romanian population and to evaluate the relationship between this anatomical variation and chronic rhinosinusitis. Secondly, we want to morphometrically evaluate the impact of Haller cells’ presence in the drainage paths of the maxillary sinuses. Materials and Methods: We conducted a randomised retrospective study that included 255 consecutive multi-detector computed tomography (MDCT) scans of the head. To carry out a comparative evaluation of the association of Haller cells with chronic rhinosinusitis, we divided the patients into two subgroups, a seasonal-based sample, between November 2022 and January 2023, and June 2023 and August 2023, respectively. We report the mean ± standard deviation for the continuous variables. To compare the results, we used the following statistical tests: a chi-squared test and a paired Student’s t-test (one-tail). Results: Our study identified a high prevalence of Haller cells, namely in 128 out of 255 patients (50.2%). There were no statistically significant associations between the presence of HCs and the age and the gender of the sample, respectively. The unilocular morphotype predominates in unilateral shapes and in bilateral shapes as well (p = 0.002). Our study identified the correlation between the Haller cells and the chronic rhinosinusitis in both research samples: “Winter group” and “Summer group” (p = 0.0002 and p = 0.0001, respectively). Conclusions: It was determined that for 40 out of 42 patients, the presence of HCs changes the morphometric pattern of the infundibular maxillary sinus.

5 October 2026 in Medical Sciences
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Journal Article
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ANAlin Horatiu Nedelcu
Alin Horatiu Nedelcu
EAEmil Anton
Emil Anton
ALAncuta Lupu
Ancuta Lupu
RTRazvan Tudor Tepordei
Razvan Tudor Tepordei
SVSimona Alice Partene Vicoleanu
Simona Alice Partene Vicoleanu
MUManuela Ursaru
Manuela Ursaru
Background: Coronary artery disease remains the leading cause of morbidity and mortality worldwide. Increasing evidence has demonstrated that many acute coronary events originate not from severely obstructive lesions but from structurally unstable atherosclerotic plaques. Consequently, the identification of vulnerable plaques has become a major objective in contemporary cardiovascular imaging. Coronary computed tomography angiography (CCTA) has evolved from a modality primarily focused on luminal stenosis assessment into a comprehensive non-invasive technique capable of evaluating plaque morphology, composition, and overall coronary atherosclerotic burden. Results: Our review summarizes current evidence regarding the role of CCTA in the detection and characterization of vulnerable coronary plaques. Particular emphasis is placed on imaging biomarkers associated with plaque instability, including low-attenuation plaque, positive remodeling, spotty calcifications, and the napkin-ring sign, which have been consistently linked to an increased risk of adverse cardiovascular events. Advances in quantitative plaque analysis have further enhanced the ability of CCTA to assess plaque burden and monitor disease progression. Emerging technologies are rapidly expanding the capabilities of coronary CT imaging. Spectral CT techniques and photon-counting detector CT offer improved tissue characterization and enhanced visualization of plaque components. In parallel, artificial intelligence and machine learning algorithms are enabling automated plaque detection, segmentation, and risk prediction, facilitating more precise and reproducible analysis of large imaging datasets. Conclusions: Despite these advances, limitations remain, including restricted spatial resolution for microstructural plaque assessment and the limited ability of conventional CT to directly evaluate biological processes such as inflammation. Future developments integrating advanced CT technologies, artificial intelligence, and multimodality imaging are expected to further improve the non-invasive identification of vulnerable plaques and personalized cardiovascular risk stratification.

9 April 2025 in Romanian Journal of Oral Rehabilitation
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Journal Article
Open access
ANAlin Horatiu Nedelcu
Alin Horatiu Nedelcu
Loredana Liliana HurjuiLoredana Liliana Hurjui
Loredana Liliana Hurjui
RTRazvan Tudor Tepordei
Razvan Tudor Tepordei
MMMarius Constantin Moraru
Marius Constantin Moraru
GSGabriel Statescu
Gabriel Statescu
CTCristina Claudia Tarniceriu
Cristina Claudia Tarniceriu
Introduction: The atlas, or first cervical vertebra (C1), plays a crucial role in the craniovertebral junction. Unlike typical vertebrae, it lacks a vertebral body and is instead made up of two lateral masses connected by the anterior and posterior arches. Additionally, C1 is often associated with various congenital abnormalities, including defects in the posterior arch (PAD). The goal of our study is to characterize the defects of the C1 posterior arch, to identify the prevalence of this developmental anomaly in the population of north-eastern Romania and to objectivise the association with other C1 malformations. Materials and Methods: Our retrospective study encompassed 715 patients who underwent cranio-cerebral CT scans between May 2022 and August 2024. Two experienced radiologists reviewed the DICOM files. Results: In our cohort, we identified posterior arch defects (PADs) of the atlas in 1.95% of patients (14 out of 715). Our analysis revealed no significant differences related to sex, with the cases being equally distributed between seven women and seven men. The age group distribution was also similar, further supporting the notion that PADs are incidental findings. Although 4 out of 14 cases of PADs were associated with other malformations, statistical significance was not achieved. Conclusions: Posterior arch defects of the atlas are relatively common congenital malformations in the population of north-eastern Romania. The most frequent morphological form is median dehiscence, which aligns with Type A. These defects do not show a sex or age predominance, consistent with their classification as congenital malformations.