Vitamin D is a fat-soluble secosteroid that plays a significant role in the whole body, including the maxillofacial region. The discovery of its receptors in many cells and organs made it possible to reveal the participation of vitamin D not only in the regulation of calcium phosphate metabolism, but also in immune processes, in providing anti-inflammatory and antimicrobial effects, slowing down cell proliferation and stimulating differentiation. In this literature review, we demonstrate the association between low vitamin D levels and the development of recurrent aphthous stomatitis, the course and response to treatment of squamous cell carcinoma of the oral cavity, the severity of periodontal diseases, and the processes of osseointegration and bone remodeling during dental implantation and guided tissue regeneration. The aim of our article was to demonstate a possible connection between vitamin D level and the oral diseases that can be presented at an oral surgery appointment, which will help clinicians to reduce the risk of early dental implant failure, ensure favorable outcomes of augmentative operations, as well as decrease the destructive effects of severe periodontitis and other conditions throug knowledge and timely lab tests and endocrinologist prescriptions.

Autotransplantation of teeth is a considerable option for tooth replacement in adults who are to undergo orthodontic treatment. Being compared with dental implantation, this procedure is more preferable as a grafted tooth functions as a normal one. In this case report, we describe successful autotransplantation of the third molar with complete root formation. To provide better adaptation of the donor tooth, we used its preoperatively printed replica. The donor tooth was immediately placed to the recipient site and splinted for 28 days. Endodontic treatment was initiated 2 weeks after transplantation. Clinical and radiographic findings at 6 and 12 months of follow-up are compared with the results described in the literature.

Total rehabilitation is one of the most sophisticated kinds of dental implant‐supported prosthetics. The usage of multiunit abutment system allows the clinician an accurate and passive fitting of screw‐retained full‐arch construction. In addition, it retains a condition of soft and bone tissues around prosthetic construction. The aim of this case is to demonstrate a modern approach in planning and realisation of full‐mouth screw‐retained dental implant prosthetics. A 59‐year‐old patient had an extraction of all failed teeth on upper and lower jaws with immediate 16 implant placement (8 implants on maxilla and 8 implants on mandible) using surgical template. Multiunit abutments were installed intraoperatively. Temporary constructions were fixed immediately after surgery. After 3 months of dental impressions, plaster models and their scan were prepared to make final screw‐retained zirconium dioxide constructions. Reevaluation of functional and aesthetic result of the treatment was made after 12 months.

Periodontal regeneration remains one of the most demanding challenges in oral bioengineering due to the structural complexity of the periodontium and the inflammatory microenvironment accompanying disease. Conventional surgical and pharmacological therapies often fail to achieve full restoration of bone, ligament and cementum, prompting the development of cell-based and biomaterial-assisted approaches. This review summarizes current advances in cellular technologies for periodontal regeneration, emphasizing the biological rationale, material design and delivery methods shaping next-generation treatments. We discuss stem-cell-based strategies employing periodontal ligament, dental pulp and mesenchymal stem cells, their paracrine and immunomodulatory roles, and how their therapeutic potential is enhanced through integration into engineered scaffolds. Recent progress in hydrogel systems, microspheres, decellularized matrices and 3D bioprinting is analyzed, highlighting how structural cues, bioactive nanoparticles and gene-modified cells enable multi-tissue regeneration. Emerging delivery and biofabrication techniques, from manual seeding to automated and in situ printing, are reviewed as key determinants of clinical translation. The convergence of bioprinting precision, immune-responsive biomaterials and personalized cellular constructs positions periodontal bioengineering as a rapidly maturing field with strong prospects for functional restoration of diseased oral tissues.

Relevance. Implant-supported prostheses are currently one of the most popular rehabilitation methods in partially or fully edentulous patients. Peri-implant soft tissue thickness is one of the principal determinants to achieve an aesthetic result and prevent the development of mucositis and peri-implantitis.Material and methods. The study included 30 partially edentulous patients with a lack of soft tissue thickness in the planned surgery site. 15 patients underwent augmentation using a collagen matrix (group 1) and 15 patients – with a free connective tissue graft (group 2). The primary endpoint was the assessment of soft tissue thickness gain three months after the surgery. The secondary endpoints were the thickness assessment of keratinized attached gingiva (three months after the surgery), swelling and pain severity (on the 1^st, 3^rd, 5^th, 7^th day, 1 and 3 months after the surgery) and quality of life evaluation (OHIP-14) (before the surgery, seven days and three months after the surgery).Results. The soft tissues thickness gain was 1.181 ± 0.11 mm in group 1, 1.55 ± 0.11 mm – in group 2. The surgery took 8.4 minutes less (from 3.737 to 13.06) in group 1 than in group 2. The swelling assessment on the next day after surgery showed that the mean value was 2.73 ± 0.3 in group 1, 1.87 ± 0.74 – in group 2 (р = 0.0139). There were no statistically significant differences in the change in the width of the keratinized attached gingiva, pain syndrome and changes in patients' quality of life (p > 0.05)Conclusion. Collagen matrix, like a free connective tissue graft, is an effective way to increase the soft tissue thickness around dental implants.