While efficient removal of uremic toxins and accumulated water is pivotal for the well-being of dialysis patients, protein adsorption to the dialyzer membrane reduces the performance of a dialyzer. Hydrophilic membrane modification with polyvinylpyrrolidone (PVP) has been shown to reduce protein adsorption and to stabilize membrane permeability. In this study we compared middle molecule clearance and filtration performance of nine polysulfone-, polyethersulfone-, and cellulose-based dialyzers over time. Protein adsorption was simulated in recirculation experiments, while β2-microglobulin clearance as well as transmembrane pressure (TMP) and filtrate flow were determined over time. The results of this study showed that β2-microglobulin clearance (−7.2 mL/min/m²) and filtrate flow (−54.4 mL/min) decreased strongly during the first 30 min and slowly afterwards (−0.7 mL/min/m² and −6.8 mL/min, respectively, for the next 30 min); the TMP increase (+37.2 mmHg and +8.6 mmHg, respectively) showed comparable kinetics. Across all tested dialyzers, the dialyzer with a hydrophilic modified membrane (FX CorAL) had the highest β2-microglobulin clearance after protein fouling and the most stable filtration characteristics. In conclusion, hydrophilic membrane modification with PVP stabilizes the removal capacity of middle molecules and filtration performance over time. Such dialyzers may have benefits during hemodiafiltration treatments which aim to achieve high exchange volumes.

The characteristics of polystyrene (PS) microplastic (MP) microfiltration by a cellulose acetate (CA) membrane were investigated within this study. Particle sizes and pore sizes were selected in a comparable range in order to challenge the dead-end microfiltration. Backwashing experiments round up the investigations. Microfiltration characteristics and particle size measurements, as well as a particle fouling analysis by different methods, were applied in the study in order to provide a comprehensive picture of particle deposition and particle fouling structuring. The particle removal efficiency was particle-size-dependent, and especially small particles were further reduced during the proceeding filtration, while the larger particles were already removed within the first minutes of filtration. This observation was attributed to the pore blocking (internal and/or complete) and build-up of the filter cake. The difference in the particle-fouling structure at low and elevated filtration pressure significantly influences the backwashing efficiency. The particle fouling resulting from low-pressure filtration was completely removed due to the backwashing procedure applied, while an increased filtration pressure resulted in a different particle-fouling structure, which negatively influenced the backwashing efficiency. This knowledge of the formation and structure of the MP particle fouling and its removal by backwashing is a prerequisite for further process development.