Background: In recent years, social media and AI have indirectly taken control of our daily lives. We bring attention to the impact that social networks, photo-editing applications, and artificial intelligence have on potential patients when they are looking for a surgeon for a possible cosmetic surgery, as well as the criteria they consider in relation to the interest in the use of the internet by surgeons. Methods: A systematic review of the past 10 years (2014–2024) was conducted following the PRISMA structure. PubMed and Google Scholar were searched for articles containing the following terms: plastic/esthetic surgery, social media, AI, filters, dysmorphia. All articles were saved using Zotero software version 6.0.37. We reported a prospective study including a 141 patients applying for esthetic surgical interventions in the time interval between February and October 2021. It also involved 44 esthetic surgeons from Tunisian clinics. The influence of social media was evaluated using questionnaires made based on the literature. Results: Using the keyword search, 71 articles were found. A total of 19 articles were selected for data extraction. It was observed that in the last 3 years, the literature has focused on photo-editing and AI in the cosmetic surgery field. A total of 107 patients chose their surgeon based on a surgeon’s social medias rather than their reputation and their website. Conclusions: The increased advancements of the internet have clearly influenced decision making in the field of cosmetic surgery.

Burn injury triggers a complex inflammatory cascade in which the interplay between pro- and anti-inflammatory mediators determines recovery or progression to sepsis, ventilator-associated pneumonia (VAP) or multi-organ dysfunction, and mortality. We systematically searched PubMed, Embase, Cochrane Library, Web of Science, and Scopus for studies published between 2006 and 2024, identifying 1883 records. We conducted a comprehensive systematic review in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. After screening and eligibility assessment, 24 studies covering both pediatric and adult populations met the inclusion criteria. Data on cytokines, acute-phase proteins, complement fragments, and systemic inflammatory indices were synthesized narratively. The evidence indicates that the inflammatory response to burn injury is not a linear sequence of events but a dynamic and unstable equilibrium, where outcomes are determined less by the initial magnitude of cytokine release and more by the persistence of dysregulated inflammation or failure of compensatory mechanisms.

Background/Objectives: The aim is to bring attention to the existence of a rare type of trauma of the hand, high-pressure injection injury, that appears to be minor with negligible signs and symptoms within the first hours after the accident, but in reality, produces significant tissue destruction with severe consequences. Recognizing this type of trauma by medical personnel, understanding the mechanisms involved, and knowing the etiological and prognostic factors can lead to early treatment initiation and avoid severe mutilating sequelae. Methods: A retrospective study on 16 patients diagnosed with high-pressure injection injuries, including water, air, paint, paint mixed paint with thinner, petroleum jelly, and lime (washable paint containing calcium oxide). The patients’ epidemiological data, the time from accident to diagnosis, reasons for delayed diagnosis, treatments applied, and outcomes were recorded and evaluated. Results: All injuries occurred at the workplace due to negligence. Oil-based paint was implicated in 31.25% of cases. The most frequently affected anatomical region was the volar surface of the distal phalanx of the nondominant hand index finger. In one case, delayed presentation to medical care and diagnosis resulted in a compartment syndrome, requiring amputation. Conclusions: It is crucial to recognize and understand this type of trauma, as it constitutes an emergency due to its rapid progression. Delayed diagnosis can result in massive tissue destruction, potentially leading to the loss of limb segments and debilitating functional sequelae, which may severely impact a patient’s socio-professional life.

Background/Objectives: Calciphylaxis or calcific uremic arteriolopathy is a rare but highly lethal pathology that occurs most frequently in a uremic context, although it can also occur outside of this context. It is characterized by the appearance of necrotic skin lesions. Localization to the upper limbs is rare and has a similarly progressive evolution. Methods: We present a series of two cases—a male and a female—with calciphylaxis diagnoses (including biopsies) and with the patients undergoing dialysis for end-stage renal disease, both with infected and extensive necrotic lesions to the hands and fingers. Both cases required serial debridement treatments and amputations. A literature review was conducted using the precise search terms “calciphylaxis”, “upper limb”, “uremic calcific arteriolopathy”, and “end-stage renal disease” from January 2010 to May 2024. Results: One of the two reported cases ended with the patient’s death. The results of the literature review (comprising seven similar cases) confirmed the rarity of calciphylaxis lesion localization to the upper limbs and the high mortality rate among these patients despite administered treatments. No therapeutic protocol for these cases was confirmed. Conclusions: The treatment of calciphylaxis cases is multidisciplinary. Although surgical intervention is controversial, it is necessary in some cases, sometimes serially. Localization to the thoracic limbs has the same evolution and poor prognosis as other localizations. A standardized therapeutic protocol for these cases is still far from being established.

Background/Objectives: Radiotherapy can severely impair skin and soft tissue healing, particularly when high doses or subsequent surgical interventions are involved. Robust experimental platforms that replicate clinically relevant radiation-impaired wound healing remain limited. This study aims to establish a reproducible experimental model for radiation-induced cutaneous injury using contemporary clinical radiotherapy techniques. Methods: A Wistar rat model was developed using single-dose external beam irradiation delivered by clinical-grade volumetric modulated arc therapy (VMAT; 6 MV FFF), at doses of 20 Gy or 30 Gy. Animals were distributed in five distinct groups: G1—control, G2—20 Gy irradiation only, G3—20 Gy irradiation followed by excision, G4—excision only, G5—30 Gy irradiation only. Standardized full-thickness skin excision (1.5 × 1.5 cm) was performed one-week post-irradiation to simulate surgical intervention in pre-irradiated tissue. Animals were monitored for up to 42 days, through skin damage macroscopic scoring, body weight, hematological and biochemical parameters, and a qualitative histological exam. Results: Single-dose irradiation with 20 Gy induced moderate, self-limiting radiation dermatitis with complete healing. When combined with delayed excision, 20 Gy irradiation resulted in more severe and prolonged wound healing impairment, and transient systemic alterations. Excision alone produced controlled wounds with predictable healing. Exploratory observations following 30 Gy irradiation revealed severe cutaneous injury and marked systemic involvement, with a high mortality rate. Conclusions: This study establishes a foundational model for radiation-impaired wound healing using clinical-grade VMAT delivery and standardized delayed excision. The 20 Gy-based protocols provide an ethically sustainable and experimentally tractable platform for future mechanistic and therapeutic studies.

Background: The Meek micrografting technique remains an important option in burn reconstruction, particularly when donor sites are limited. By expanding a small split-thickness skin graft into a regularly spaced micrograft array, the method can achieve expansion ratios well beyond those of conventional meshed grafting. This systematic review aims to synthesize the clinical evidence on the Meek technique, its technical evolution since 1958, and its performance relative to mesh grafting across the full spectrum of burn severity. Methods: A systematic review of the surgical literature was conducted according to PRISMA 2020 recommendations. Searches were performed in PubMed, Scopus, and Web of Science from 1958 to 2026, using combinations of the terms Meek technique, Meek micrografting, microdermagrafting, burns, wound coverage, and skin graft expansion. Eligible studies included clinical outcome reports, comparative analyses with mesh grafting, randomized controlled trials, and technical modifications of the Meek method. Results: The search yielded 412 records, of which 15 unique publications met inclusion criteria and were synthesized, including a 2025 intra-patient randomized controlled trial conducted in a mixed wound population. Reports documented the evolution of the Meek technique from its original description in 1958 to contemporary refinements, while clinical studies reported expansion ratios of 1:2 to 1:9 and variable graft-take estimates, often around or above 80% in extensive burns. At the 1:2–1:3 expansion ratios studied, however, the only completed randomized controlled trial found mesh grafting superior to Meek micrografting for graft take and short-term scar quality, indicating that the relative advantage of Meek is most consistent in donor-site-limited injuries requiring high expansion ratios rather than a universal benefit. Conclusions: The Meek technique remains a reproducible and valuable strategy for burn reconstruction when donor sites are critically limited, but current randomized evidence does not support its routine use over mesh grafting within the population and expansion ratios studied, and the available evidence does not establish a universal TBSA threshold for selecting between the two techniques. Future research should prioritize randomized comparisons across a wider range of burn sizes and standardized long-term scar outcome reporting.