Although previous studies have suggested that meteorological factors are associated with Bell’s palsy, articles on this topic are rare and the results are inconsistent. We aim to reveal the relationship between exposure to different meteorological factors and the onset of severe Bell’s palsy (SBP) with daily data. A case-crossover study based on time-series data was applied, and the minimum risk value of each climatic factor was set as the reference value. We fitted a distributed lag non-linear model (DLNM) which applied quasi-Poisson regression to evaluate the exposure-response association and the lag-response association of meteorological factors on the occurrence of SBP. The mode value and per-decile interval value of each meteorological factor were all included in the analysis. Sensitivity analyses were conducted to test the robustness of results. A total of 863 SBP patients (474 males and 389 females) from 7 hospitals in the Shenzhen Futian District were selected from January 2009 to February 2020. The highest relations effect was tested in the cumulative exposure-response result shown as follows; mean temperature at the minimum value 15.3°C with RR of 10.370 (1.557–69.077) over lag 0 to 13; relative humidity at the 30th value 71% with RR of 8.041 (1.016–63.616) over lag 0 to 14; wind speed at the 90th value 31 (0.1 m/s) with RR of 1.286 (1.038–1.593) over lag 0; mean air pressure at the 30th value 1001.4 (pa) with RR of 9.052 (1.039–78.858) over lag 0 to 5; visibility at the 80th value 26.5 (km) with RR of 1.961 (1.005–1.423) over lag 0 to 2; average total cloud cover at the max value 100 (%) with RR 1.787 (1.014–3.148) over lag 0 to 2; sunshine duration at the 10th value 0.1 (h) with RR of 4.772 (1.018–22.361); daily evaporation shows no relationship in the cumulative result; daily average solar radiation at the minimum value 0 (W/m ² ) with RR of 5.588 (1.184–26.382). There is a relationship between wind speed and the onset of SBP, while mean air pressure, visibility, and average total cloud cover, especially sunshine duration and solar radiation which showed a strong effect, may be associated with severe clinical symptoms of SBP. Mean temperature and relative humidity may affect the course of SBP.

Background: Systemic therapy-associated insomnia is highly prevalent among patients with breast cancer. However, no meta-analysis has explored the efficacy of acupuncture for Systemic therapy-associated insomnia among patients with cancer.Methods: According to the PRISMA Statement, randomized controlled trials (RCTs) through April 2024 were identified and extracted from PubMed, Embase, and the Cochrane CENTRAL Register of Controlled Trials. The quality of the RCTs was assessed using the Cochrane Systematic Review Handbook 5.1 and its recommended risk-of-bias assessment tool. Two independent investigators screened and extracted the data and performed statistical analysis using RevMan5.3.Results: Of the total 411 studies identified, 4 RCTs were analyzed. The meta-analysis revealed that acupuncture significantly improved the total sleep time and sleep efficiency relative to wait-list control or sham EA among patients with breast cancer experiencing insomnia after systemic therapy (mean difference [MD] 29.86, 95% confidence interval [CI] 16.20–43.51, P < 0.0001 and MD 4.56, 95% CI 1.84–7.29, P = 0.001), reduced the pittsburgh sleep quality index (PSQI) relative to wait-list control or sham EA with an MD of −0.87 (95% CI −1.60 to -0.15, P = 0.02, I² = 25%) in 4 weeks and an MD of −0.82 (95% CI −1.60 to -0.04, P = 0.04, I² = 12%) in 8 weeks, and reduced the hospital anxiety and depression scale (HADS)-anxiety both in 4 weeks with an MD of −0.85 (95% CI −1.42 to -0.27, P = 0.004, I² = 0%) and in 8 weeks with an MD of −0.94 (95% CI −1.56 to −0.32, P = 0.003, I² = 0%. However, no significant differences in insomnia severity index (MD −2.15, 95% CI −5.07 to 0.78, P = 0.15 and MD −1.48, 95% CI −3.91 to 0.94, P = 0.23), and HADS-depression (MD −0.67, 95% CI −2.32 to 0.99, P = 0.43 and MD −0.63, 95% CI −2.39 to 1.12, P = 0.48) in 4 and 8 weeks were observed between the acupuncture group and the wait-list control or sham EA group.Conclusion: Acupuncture has a great potential to be used in the management of systemic therapy-associated insomnia in patients with breast cancer. More studies with rigorous designs and larger sample sizes are warranted to verify the efficacy and safety of acupuncture for insomnia among patients with breast cancer.

To explore the theoretical framework of lung cancer caregivers’ skill model and lay a foundation for the follow-up practical research. Based on the g