Glaucoma is chronic eye disease that leads to irreversible vision loss. The Cup-to-Disc Ratio (CDR) serves as the most important indicator for glaucoma screening and plays an significant role in clinical screening and early diagnosis of glaucoma. In general, obtaining CDR is subjected to measuring on manually or automatically segmented optic disc and cup. Despite great efforts have been devoted, obtaining CDR values automatically with high accuracy and robustness is still a great challenge due to the heavy overlap between optic cup and neuroretinal rim regions. In this paper, a direct CDR estimation method is proposed based on the well-designed semi-supervised learning scheme, in which CDR estimation is formulated as a general regression problem while optic disc/cup segmentation is cancelled. The method directly regresses CDR value based on the feature representation of optic nerve head via deep learning technique while bypassing intermediate segmentation. The scheme is a two-stage cascaded approach comprised of two phases: unsupervised feature representation of fundus image witha convolutional neural networks (MFPPNet) and CDR value regression by random forest regressor. The proposed scheme is validated on the challenging glaucoma dataset Direct-CSU and public ORIGA, and the experimental results demonstrate that our method can achieve a lower average CDR error of 0.0563 and a higher correlation of around 0.726 with measurement before manual segmentation of optic disc/cup by human experts. Our estimated CDR values are also tested for glaucoma screening, which achieves the areas under curve of 0.905 on dataset of 421 fundus images. The experiments show that the proposed method is capable of state-of-the-art CDR estimation and satisfactory glaucoma screening with calculated CDR value.

Existing view-invariant gait recognition methods encounter difficulties due to limited number of available gait views and varying conditions during training. This paper proposes gait partial similarity matching that assumes a 3D object shares common view surfaces in significantly different views. Detecting such surfaces aids the extraction of gait features from multiple views; 3D parametric body models are morphed by pose and shape deformation from a template model using 2D gait silhouette as observation. The gait pose is estimated by a level set energy cost function from silhouettes including incomplete ones. Body shape deformation is achieved via Laplacian deformation energy function associated with inpainting gait silhouettes. Partial gait silhouettes in different views are extracted by gait partial region of interest elements selection and re-projected onto 2D space to construct partial gait energy images. A synthetic database with destination views and multi-linear subspace classifier fused with majority voting is used to achieve arbitrary view gait recognition that is robust to varying conditions. Experimental results on CMU, CASIA B, TUM-IITKGP, AVAMVG, and KY4D data sets show the efficacy of the propose method.