Thomas Mavromoustakos

Prof. Thomas Mavromoustakos

Department of Chemistry, National & Kapodistrian University of Athens, Greece
orcid

Research Focus & Metrics

Academic Career Length

39Years (1988-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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Vlasios GoulasVlasios Goulas
Vlasios Goulas
ESEvgenios Stylos
Evgenios Stylos
MCMaria V. Chatziathanasiadou
Maria V. Chatziathanasiadou
Thomas MavromoustakosThomas Mavromoustakos
Thomas Mavromoustakos
ATAndreas Tzakos
Andreas Tzakos
The contribution of natural products to the drug-discovery pipeline has been remarkable since they have served as a rich source for drug development and discovery. Natural products have adapted, during the course of evolution, optimum chemical scaffolds against a wide variety of diseases, including cancer and diabetes. Advances in high-throughput screening assays, assisted by the continuous development on the instrumentation’s capabilities and omics, have resulted in charting a large chemical and biological space of drug-like compounds, originating from natural sources. Herein, we attempt to integrate the information on the chemical composition and the associated biological impact of carob fruit in regards to human health. The beneficial and health-promoting effects of carob along with the clinical trials and the drug formulations derived from carob’s natural components are presented in this review.

17 December 2023 in Molecules
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NGNikitas Georgiou
Nikitas Georgiou
MKMargarita Georgia Kakava
Margarita Georgia Kakava
EREfthymios Alexandros Routsi
Efthymios Alexandros Routsi
EPErrikos Petsas
Errikos Petsas
NSNikolaos Stavridis
Nikolaos Stavridis
Thomas MavromoustakosThomas Mavromoustakos
Thomas Mavromoustakos
The study of natural products as potential drug leads has gained tremendous research interest. Quercetin is one of those natural products. It belongs to the family of flavonoids and, more specifically, flavonols. This review summarizes the beneficial pharmaceutical effects of quercetin, such as its anti-cancer, anti-inflammatory, and antimicrobial properties, which are some of the quercetin effects described in this review. Nevertheless, quercetin shows poor bioavailability and low solubility. For this reason, its encapsulation in macromolecules increases its bioavailability and therefore pharmaceutical efficiency. In this review, a brief description of the different forms of encapsulation of quercetin are described, and new ones are proposed. The beneficial effects of applying new pharmaceutical forms of nanotechnology are outlined.

28 April 1999 in Journal of Medicinal Chemistry
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Thomas MavromoustakosThomas Mavromoustakos
Thomas Mavromoustakos
AKAntonios Kolocouris
Antonios Kolocouris
MZMaria Zervou
Maria Zervou
PRPanagiota Roumelioti
Panagiota Roumelioti
John MatsoukasJohn Matsoukas
John Matsoukas
RWRudiger Weisemann
Rudiger Weisemann

8 March 2001 in Inorganic Chemistry
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Journal Article
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MMManolis Matzapetakis
Manolis Matzapetakis
MKM. Kourgiantakis
M. Kourgiantakis
MDM. Dakanali
M. Dakanali
Catherine RaptopoulouCatherine Raptopoulou
Catherine Raptopoulou
ATA. Terzis
A. Terzis
ASA. Salifoglou
A. Salifoglou

1 June 2011 in Current Medicinal Chemistry
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Thomas MavromoustakosThomas Mavromoustakos
Thomas Mavromoustakos
SDSerdar Durdagi
Serdar Durdagi
CKC. Koukoulitsa
C. Koukoulitsa
MSM. Simcic
M. Simcic
MPM. G. Papadopoulos
M. G. Papadopoulos
Simona Golič GrdadolnikSimona Golič Grdadolnik
Simona Golič Grdadolnik
Rational design is applied in the discovery of novel lead drugs. Its rapid development is mainly attributed to the tremendous advancements in the computer science, statistics, molecular biology, biophysics, biochemistry, medicinal chemistry, pharmacokinetics and pharmacodynamics experienced in the last few decades. The promising feature that characterizes the application of rational drug design is that it uses for developing potential leads in drug discovery all known theoretical and experimental knowledge of the system under study. The utilization of the knowledge of the molecular basis of the system ultimately aims to reduce human power cost, time saving and laboratory expenses in the drug discovery. In this review paper various strategies applied for systems which include: (i) absence of knowledge of the receptor active site; (ii) the knowledge of a homology model of a receptor, (iii) the knowledge of the experimentally determined (i.e. X-ray crystallography, NMR spectroscopy) coordinates of the active site of the protein in absence and (iv) the presence of the ligand will be analyzed.

1 January 2002 in Ultrasonics Sonochemistry
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Journal Article
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Christos PappasChristos Pappas
Christos Pappas
Petros A. TarantilisPetros A. Tarantilis
Petros A. Tarantilis
IDI. Daliani
I. Daliani
Thomas MavromoustakosThomas Mavromoustakos
Thomas Mavromoustakos
MPM. Polissiou
M. Polissiou
A comparative study of classical and ultrasound-assisted extraction and purification of cellulose from kenaf (Hibiscus cannabinus L.) and eucalyptus (Eucalyptus rodustrus Sm.), has been conducted. The isolated cellulose samples were studied by diffuse reflectance infrared Fourier transform spectroscopy and 13C nuclear magnetic resonance (13C-NMR) spectroscopy and the crystallinity was also determined. The use of ultrasound decreased the total time of treatment, in addition the purity of the obtained cellulose was very high.