In recent decades, immunotherapy has been considered a promising treatment approach. The modulatable enhancement or attenuation of the body’s immune response can effectively suppress tumors. However, challenges persist in clinical applications due to the lack of precision in antigen presentation to immune cells, immune escape mechanisms, and immunotherapy-mediated side effects. As a potential delivery system for drugs and immunomodulators, mesoporous silica has attracted extensive attention recently. Mesoporous silica nanoparticles (MSNs) possess high porosity, a large specific surface area, excellent biocompatibility, and facile surface modifiability, making them suitable as multifunctional carriers in immunotherapy. This article summarizes the latest advancements in the application of MSNs as carriers in cancer immunotherapy, aiming to stimulate further exploration of the immunomodulatory mechanisms and the development of immunotherapeutics based on MSNs.

The clock gene PER1 plays an important role in regulating the clock gene network in human oral squamous cell carcinoma cells The clock gene PER1 plays an important role in regulating the clock gene network in human oral squamous cell carcinoma cells

Harvesting autologous soft tissue from the hard palate is a standard procedure, but managing the donor site wound is critical for patient comfort and reducing complications. Traditional methods like palatal stents are often costly and uncomfortable. While commercially available mucoadhesive bandages offer a barrier, their adhesion alone is temporary and unreliable, often failing prematurely due to oral movements. A novel "palatal shield" technique using composite resin stabilized on adjacent teeth's palatal surface has been proposed to address postoperative discomfort, yet it still has limitations in adaptability. This article and accompanying video demonstrate a comprehensive protocol that overcomes this limitation by combining a collagen sponge scaffold with a mucoadhesive bandage, which is then firmly secured using stabilizing suspension sutures. The key protocol steps include: (1) placing a collagen sponge into the donor site after initial hemostasis; (2) applying the trimmed mucoadhesive bandage to cover the sponge and overlap onto the peripheral dry mucosa; and (3) firmly securing the entire dressing using crossed horizontal mattress suspension sutures. This multi-layer system creates a stable, long-lasting physical barrier that protects the underlying wound from mechanical irritation and bacterial contamination, addressing the issue of donor site morbidities such as postoperative bleeding and pain that plague both clinicians and patients. This method provides immediate hemostasis, significantly reduces postoperative pain, and promotes predictable, advanced healing. Compared to novel palatal stents made of light-curing hybrid composite resin, where some patients report speaking inconvenience, this protocol avoids such functional disruptions. Additionally, it eliminates the need for extra fabrication steps required by transparent palatal plates used in combination with artificial dermis. This protocol provides a reliable, cost-effective, and reproducible technique that enhances patient comfort and optimizes palatal donor site healing.

Harvesting autologous soft tissue from the hard palate is a standard procedure, but managing the donor site wound is critical for patient comfort and reducing complications. Traditional methods like palatal stents are often costly and uncomfortable. While commercially available mucoadhesive bandages offer a barrier, their adhesion alone is temporary and unreliable, often failing prematurely due to oral movements. A novel "palatal shield" technique using composite resin stabilized on adjacent teeth's palatal surface has been proposed to address postoperative discomfort, yet it still has limitations in adaptability. This article and accompanying video demonstrate a comprehensive protocol that overcomes this limitation by combining a collagen sponge scaffold with a mucoadhesive bandage, which is then firmly secured using stabilizing suspension sutures. The key protocol steps include: (1) placing a collagen sponge into the donor site after initial hemostasis; (2) applying the trimmed mucoadhesive bandage to cover the sponge and overlap onto the peripheral dry mucosa; and (3) firmly securing the entire dressing using crossed horizontal mattress suspension sutures. This multi-layer system creates a stable, long-lasting physical barrier that protects the underlying wound from mechanical irritation and bacterial contamination, addressing the issue of donor site morbidities such as postoperative bleeding and pain that plague both clinicians and patients. This method provides immediate hemostasis, significantly reduces postoperative pain, and promotes predictable, advanced healing. Compared to novel palatal stents made of light-curing hybrid composite resin, where some patients report speaking inconvenience, this protocol avoids such functional disruptions. Additionally, it eliminates the need for extra fabrication steps required by transparent palatal plates used in combination with artificial dermis. This protocol provides a reliable, cost-effective, and reproducible technique that enhances patient comfort and optimizes palatal donor site healing.