The Nature Park Ponjavica (NP) is the habitat of strictly protected plant and animal species, located in AP Vojvodina, in southern Banat (Northern Serbia). The area of the park covers 302.96 ha. Protection zones I, II, and III have been established in the protected area of the NP. The NP includes the middle course of the Ponjavica River, which has preserved characteristics of watercourses of plain areas and coastal remains of wetland habitats. The most valuable area of this park in terms of protection is an island with an area of slightly less than 1 hectare. According to the IUCN (International Union for Conservation of Nature), the NP is classified as the fourth category—Habitat and species management area. The good geographical position of NP is one of its main characteristics. The NP can be a destination where specific forms of tourism can be developed, such as ecotourism, nature-based tourism, birdwatching, scientific and research tourism, etc. Numerous historical sites represent a significant potential for the development of cultural tourism. The research examined the influence of institutional, economic, ecological, and socio-cultural sustainability on the respondents’ satisfaction. The quantitative methodology in this research included a questionnaire as a survey instrument for respondents. A total of 547 residents were surveyed. The results of the research indicate that there is considerable satisfaction among residents with sustainable tourism. The results of the research can help in the development of numerous tourism development strategies in which the wetland is the primary resource.