Polysaccharides are functional foods or drugs that can be used to alleviate heavy metal poisoning by cadmium, lead, mercury, and arsenic. Industries generate substantial quantities of toxic heavy metal wastes, such as wastewater discharges, paints, electronic waste, batteries, pigments, and plastics, into the environment that pose a risk to human health. Therefore, it is imperative to eliminate accumulated heavy metal ions from the body and the environment. Heavy metal toxicity can lead to decreased energy levels and impair the functioning of vital organs, such as the brain, lungs, kidneys, liver, and blood. Prolonged exposure can result in progressive physical, muscular, and neurological degeneration that resembles conditions such as multiple sclerosis, Parkinson’s disease, Alzheimer’s disease, and muscular dystrophy. Polysaccharides operate through mechanisms such as chelation, antioxidant defense, immunomodulation, and tissue repair. Polysaccharides involved in heavy metal removal include methionine and cysteine, together with N-acetylcysteine, an acetylated form of cysteine, S-adenosylmethionine, a metabolite of methionine, α-lipoic acid, and the tripeptide glutathione (GSH). These compounds effectively bind with harmful heavy metals to create a stable complex and defend biological targets from metal ions, thus decreasing their harmful effects and causing them to be excreted from the body. This review also highlights the importance of polysaccharides’ ability to mitigate oxidative stress, enhance immune responses, and support tissue repair processes. Polysaccharides are ubiquitous in nature and take part in diverse processes, making them potential natural therapies for heavy metal-related diseases. This review discusses the effectiveness of natural polysaccharides and the mechanisms that allow them to bind with heavy metals to alleviate their effects from the body and the environment. Polysaccharides have inherent features that enable them to function as pharmacological agents and regulate the immune response.

Goats, versatile creatures selectively bred for various purposes, have become pivotal in shaping the socioeconomic landscape, particularly in rural and economically challenged areas. Their remarkable ability to withstand and adapt to extreme heat has proven invaluable, allowing them to flourish and reproduce in even the harshest climates on Earth. Goat farming has emerged as a reliable and sustainable solution for securing food resources. However, despite its significance, the goat-producing industry has received less attention than other ruminants. Despite goats’ inherent resilience to heat, their productivity and reproductive performance suffer under high ambient temperatures, leading to heat stress. This presents a significant challenge for goat production, necessitating a comprehensive multidisciplinary approach to mitigating the adverse effects of heat stress. This review aims to explore the diverse impacts of heat stress on goats and propose effective measures to address the sector’s challenges. By understanding and addressing these issues, we can enhance the resilience and sustainability of goat farming, ensuring its continued contribution to food security and socioeconomic development.

Vibrio parahaemolyticus is an important foodborne and aquaculture-associated pathogen, and its increasing antimicrobial resistance threatens shrimp production, seafood safety, and public health. Although bacteriophages have emerged as a potential solution to the growing challenge of antimicrobial resistance, whether antibiotic resistance is associated with phage tolerance remains unclear. This study characterized antimicrobial resistance profiles and resistance genes in Vibrio parahaemolyticus isolates from Zhanjiang shrimp aquaculture farms and evaluated their association with bacteriophage susceptibility. A total of 132 isolates were tested against 18 antibiotics, while molecular and phage-related analyses were performed on 132 isolates. High resistance was observed against kanamycin (95.5%), sulfamethoxazole (94.7%), cefazolin (78.8%), imipenem (78.8%), amoxicillin (70.5%), and ampicillin (65.2%). Multidrug resistance was detected in 131/132 isolates (99.24%), indicating an extensive resistance burden. PCR analysis showed high detection rates of aphA (100.00%), sul1 (99.24%), blaTEM (98.48%), blaOXA (73.48%), blaCTX-M (53.03%), qnrA (45.45%), tetA (37.88%), and tetB (21.21%). Phage response analysis showed that 70.45% and 68.18% of isolates were phage-resistant at 4 h and 5 h, respectively. Genes potentially associated with phage–host interactions were also detected, with luxS showing the highest frequency (85.61%). Association analysis revealed significant links between tetA, tetB, blaOXA, and bacteriophage responses. These findings suggest that antimicrobial resistance and reduced phage susceptibility can co-occur among V. parahaemolyticus isolates recovered from shrimp farms in Zhanjiang, highlighting the need for regional resistance surveillance and careful phage selection.

Inflammatory bowel disease (IBD), including ulcerative colitis (UC) and Crohn's disease (CD), is a recurrent gastrointestinal condition with a rising global prevalence. Current treatments, such as anti‐inflammatory drugs and biologics, are often limited by severe side effects and drug resistance, driving the search for safer alternatives. Natural polysaccharides (NPs) and their metabolites, particularly short‐chain fatty acids (SCFAs), have garnered significant interest because of their immunomodulatory, antioxidative, and microbiota‐modulating properties, positioning them as promising bioactive agents for IBD management. This review critically examines the structure–activity relationships of NPs and advanced delivery strategies, including nanoformulations, that increase their bioavailability and targeting ability. It also provides a comprehensive evaluation of the existing evidence, an in‐depth analysis of safety profiles, and a critical discussion of clinical translation prospects, addressing complexities in regulatory frameworks. By integrating recent molecular insights with translational challenges, this review aims to inform clinical practice and temper premature expectations, offering a balanced perspective on the journey of NPs from the bench to the bedside.