The activation of magnetic nanoparticles in hyperthermia treatment by an external alternating magnetic field is a promising technique for targeted cancer therapy. The external alternating magnetic field generates heat in the tumor area, which is utilized to kill cancerous cells. Depending on the tumor type and site to be targeted, various types of magnetic nanoparticles, with variable coating materials of different shape and surface charge, have been developed. The tunable physical and chemical properties of magnetic nanoparticles enhance their heating efficiency. Moreover, heating efficiency is directly related with the product values of the applied magnetic field and frequency. Protein corona formation is another important parameter affecting the heating efficiency of MNPs in magnetic hyperthermia. This review provides the basics of magnetic hyperthermia, mechanisms of heat losses, thermal doses for hyperthermia therapy, and strategies to improve heating efficiency. The purpose of this review is to build a bridge between the synthesis/coating of magnetic nanoparticles and their practical application in magnetic hyperthermia.

This paper describes a modified method to prepare monodisperse Fe ₃ O ₄ magnetic nanoparticles with different shapes (cube, octahedron, and sphere).

Magnetic nanoparticles have been intensively developed and applied in several biomedical applications such as targeted delivery, drug therapy, hyperthermia, magnetic resonance imaging and bioseparation etc. This work describes a simple and convenient method to synthesize silica coated Fe₃O₄ nanoparticles which have the potential to be used in the bioseparation of fetuin from fetal bovine serum and albumin from the egg. In this work, uniform Fe₃O₄ particles were prepared through the one-pot solvothermal process at 200 °C for 12 h using a sole iron precursor (FeCl₃ · 6H₂O) and then were coated with SiO₂ to prepare silica coated Fe₃O₄ nanoparticles by hydrolysis and condensation of tetraethyl orthosilicate in ethanol and H₂O medium. We further characterized the synthesized Fe₃O₄ and Fe₃O₄@SiO₂ using XRD, SEM, TEM, FT-IR and VSM to study phase purity, morphology, size, functionality and magnetic properties.