Although deep learning techniques have made great success in computer vision and other fields, they do not work well on Lung cancer subtype diagnosis, due to the distinction of slide images between different cancer subtypes is ambiguous. Furthermore, they often over-fit to high-dimensional genomics data with limited samples, and do not fuse the image and genomics data in a sensible way. In this paper, we propose a hybrid deep network based approach LungDIG for Lung cancer subtype Diagnosis. LungDIG firstly tiles the tissue slide image into small patches and extracts the patch-level features by fine-tuning an Inception-V3 model. Since the patches may contain some false positives in non-diagnostic regions, it further designs a patch-level feature combination strategy to integrate the extracted patch features and maintain the diversity between cancer subtypes. At the same time, it extracts the genomics features from Copy Number Variation data by an attention based nonlinear extractor. Next, it fuses the image and genomics features by an attention based multilayer perceptron (MLP) to diagnose cancer subtype. Experiments on TCGA lung cancer data show that LungDIG not only achieves higher accuracy for cancer subtype diagnosis than state-of-the-art methods, but also has a high authenticity and good interpretability.

Nowadays, prediction for medical treatment migration has become one of the interesting issues in the field of health informatics. This is because the medical treatment migration behavior is closely related to the evaluation of regional medical level, the rational use of medical resources, and the distribution of medical insurance. Therefore, a prediction model for medical treatment migration based on medical insurance data is introduced in this paper. First, a medical treatment graph is constructed based on medical insurance data. The medical treatment graph is a heterogeneous graph, which contains entities such as patients, diseases, hospitals, medicines, hospitalization events, and the relations between these entities. However, existing graph neural networks are unable to capture the time-series relationships between event-type entities. To this end, a prediction model based on Graph Convolutional Network (GCN) is proposed in this paper, namely, Event-involved GCN (EGCN). The proposed model aggregates conventional entities based on attention mechanism, and aggregates event-type entities based on a gating mechanism similar to LSTM. In addition, jumping connection is deployed to obtain the final node representation. In order to obtain embedded representations of medicines based on external information (medicine descriptions), an automatic encoder capable of embedding medicine descriptions was deployed in the proposed model. Finally, extensive experiments is conducted on a real medical insurance data set. Experimental results show that our model's predictive ability is better than the best models available.