In real cases, missing values tend to contain meaningful information that should be acquired or should be analyzed before the incomplete dataset is used for machine learning tasks. In this work, two algorithms named jointly fuzzy C-Means and vaguely quantified nearest neighbor (VQNN) imputation (JFCM-VQNNI) and jointly fuzzy C-Means and fitted VQNN imputation (JFCM-FVQNNI) have been proposed by considering clustering conception and sufficient extraction of uncertain information. In the proposed JFCM-VQNNI and JFCM-FVQNNI algorithm, the missing value is regarded as a decision feature, and then, the prediction is generated for the objects that contain at least one missing value. Specially, as for JFCM-VQNNI algorithm, indistinguishable matrixes, tolerance relations, and fuzzy membership relations are adopted to identify the potential closest filled values based on corresponding similar objects and related clusters. On the basis of JFCM-VQNNI algorithm, JFCM-FVQNNI algorithm synthetic analyzes the fuzzy membership of the dependent features for instances with each cluster. In order to fill the missing values more accurately, JFCM-FVQNNI algorithm performs fuzzy decision membership adjustment in each object with respect to the related clusters by considering highly relevant decision attributes. The experiments have been carried out on five datasets. Based on the analysis of root-mean-square error, mean absolute error, comparison of imputation values with actual values, and classification accuracy results analysis, we can draw the conclusion that the proposed JFCM-FVQNNI and JFCM-VQNNI algorithms yields sufficient and reasonable imputation performance results by comparing with fuzzy C-Means parameter-based imputation algorithm and fuzzy C-Means rough parameter-based imputation algorithm.

The use of artificial intelligence within the healthcare sector is consistently growing. However, the majority of deep learning-based AI systems are of a black box nature, causing these systems to suffer from a lack of transparency and credibility. Due to the widespread adoption of medical imaging for diagnostic purposes, the healthcare industry frequently relies on methods that provide visual explanations, enhancing interpretability. Existing research has summarized and explored the usage of visual explanation methods in the healthcare domain, providing introductions to the methods that have been employed. However, existing reviews are frequently used for interpretable analysis in the medical field ignoring comprehensive reviews on Class Activation Mapping (CAM) methods because researchers typically categorize CAM under the broader umbrella of visual explanations without delving into specific applications in the healthcare sector. Therefore, this study primarily aims to analyze the specific applications of CAM-based deep explainable methods in the healthcare industry, following the PICO (Population, Intervention, Comparison, Outcome) framework. Specifically, we selected 45 articles for systematic review and comparative analysis from three databases—PubMed, Science Direct, and Web of Science—and then compared eight advanced CAM-based methods using five datasets to assist in method selection. Finally, we summarized current hotspots and future challenges in the application of CAM in the healthcare field.