A high-fat diet and physical inactivity are key contributors to obesity, predisposing individuals to various chronic diseases, such as cardiovascular disease and diabetes, which involve multiple organs and tissues. To better understand the role of multi-organ interaction mechanisms in the rising incidence of obesity and its associated chronic conditions, treatment and prevention strategies are being extensively investigated. This review examines the signaling mechanisms between different tissues and organs, with a particular focus on the crosstalk between adipose tissue and the muscle, brain, liver, and heart, and potentially offers new strategies for the treatment and management of obesity and its complications.

Review Article From induced pluripotent stem cell (iPSC) to universal immune cells: literature review of advances in a new generation of tumor therapies Jing Zhang, Zixuan Jia, Huixin Pan, Wen Ma, Youhan Liu, Xuewen Tian, Yang Han, Qinglu Wang, Caixia Zhou, Jing Zhang

Parkinson’s disease (PD) is the second most prevalent neurodegenerative disorder, and its incidence rate is increasing at an alarming rate. Astrocytes exhibit a complex array of functions that play a critical role in the pathogenesis and progression of PD. These multifaceted functions substantially influence disease development and exacerbation. Although numerous studies have investigated the role of astrocytes in PD, the interactions between astrocytes and other cellular or molecular factors during the course of neurological deterioration in PD have not been comprehensively characterized. Therefore, this review aims to highlight the roles and functional characteristics of astrocytes in PD. Astrocytes are involved in maintaining the blood-brain barrier, clearing α-synuclein, metabolizing glutamate and fatty acids, and protecting neurons. The interactions among astrocytes, microglia, and oligodendrocytes exert dual effects on PD progression. Additionally, the recently recognized phenomena of ferroptosis and cuproptosis have been associated with astrocytic activity. The interplay and regulatory mechanisms linking these forms of cell death to apoptosis and pyroptosis of immune cells in the brain warrant further investigation. This review is intended for researchers, healthcare professionals, and clinicians involved in the study and treatment of PD and its related complications. To ensure comprehensive and unbiased coverage, a systematic literature search was conducted using major scientific databases such as PubMed, Scopus, and Web of Science. Keywords included “Parkinson’s disease”, “astrocyte”, “brain”, “signaling mechanisms”, and “α-synuclein”. Articles were selected based on their relevance to astrocyte–PD interactions, while studies lacking scientific rigor or relevance were excluded. In summary, this review synthesizes current understanding of astrocytic function and mechanisms in PD and proposes potential therapeutic directions based on these insights.

Attention deficit hyperactivity disorder (ADHD) turns into a common neuro progressional disorder. Although gender identity has obtained increasing attention in ADHD researches, its role in ADHD presentation and treatment response remains underexplored. Our review seeks to mainly delve into the effect of gender identity on ADHD, exploring the unique needs of individuals with various gender identities in the context of ADHD symptoms, diagnostic assessment, and treatment, with the goal of supplying theoretical support and practical recommendations for future research and clinical practice. The primary content includes, specifically: (1) Symptom expression differences: Gender identity significantly affects ADHD symptoms; male-identified individuals commonly perform worse in task orientation and attention stability, while female-identified individuals may demonstrate more variability in attention control and executive functions; (2) Diagnosis and treatment: Clinical practice generally neglects the impact of gender identity on ADHD management, with personalized needs of gender-identified individuals frequently not adequately addressed, potentially, affecting treatment outcomes; and (3) Future research directions: Future studies should further assess how gender identity affects the specific mechanisms of ADHD, conduct researches in multicultural contexts, and engage in long-term follow-up studies to evaluate the long-term impact of gender identity on ADHD progression. Besides, enhanced funding and public education on the relationship between gender identity and ADHD are needed to advance the field.

Parkinson disease (PD) is the second largest and most common neurodegenerative disease globally, following Alzheimer disease. Its pathological features include the deformation and loss of dopaminergic neurons in the substantia nigra pars compacta of the midbrain, as well as the aggregation of α-synuclein in the form of Lewy bodies. This leads to motor symptoms such as resting tremors, muscle rigidity, bradykinesia, and postural instability, as well as non-motor symptoms including cognitive, emotional, and sleep disorders. Currently, PD is mainly treated by medication and surgery. Medication, though widely used, has limited efficacy and causes adverse reactions. With the intensification of global aging and the annual increase in the incidence of PD, the limitations of existing treatment approaches have become increasingly prominent, and there is an urgent need to explore safer and more effective treatment strategies. Numerous clinical studies have demonstrated that exercise rehabilitation training can not only effectively ameliorate the motor and non-motor symptoms of PD patients, but also promote the generation of neurotrophic factors, neurotransmitters, and hormones, and regulate the dopaminergic system. Therefore, an in-depth exploration of the mechanisms and effects of different exercise rehabilitation training methods in the treatment of PD holds great significance for refining the comprehensive treatment plan for PD and enhancing the quality of life of patients. This article will conduct a comprehensive review of the mechanisms and effects of various exercise rehabilitation training methods in treating PD.