This work is crucial for investigating the antiproliferative effect of a phenyl isoserine derivative. The action of the phenyl isoserine derivative was estimated utilizing the ex vivo rat aorta ring (RAR) assay, cytotoxicity assay on human breast cancer cell line MCF-7, gene expression analysis for Vascular endothelial growth factor (VEGF) by real-time PCR, ADME/Tox profiling, and molecular docking studies. The findings indicated that the phenyl isoserine derivative had considerable antiangiogen