Epigenetic changes, host–gut microbiota interactions, and environmental factors contribute to inflammatory bowel disease (IBD) onset and progression. A healthy lifestyle may help to slow down the chronic or remitting/relapsing intestinal tract inflammation characteristic of IBD. In this scenario, the employment of a nutritional strategy to prevent the onset or supplement disease therapies included functional food consumption. Its formulation consists of the addition of a phytoextract enriched in bioactive molecules. A good candidate as an ingredient is the Cinnamon verum aqueous extract. Indeed, this extract, subjected to a process of gastrointestinal digestion simulation (INFOGEST), exhibits beneficial antioxidant and anti-inflammatory properties in an in vitro model of the inflamed intestinal barrier. Here, we deepen the study of the mechanisms related to the effect of digested cinnamon extract pre-treatment, showing a correlation between transepithelial electrical resistance (TEER) decrement and alterations in claudin-2 expression under Tumor necrosis factor-α/Interleukin-1β (TNF-α/IL-1) β cytokine administration. Our results show that pre-treatment with cinnamon extract prevents TEER loss by claudin-2 protein level regulation, influencing both gene transcription and autophagy-mediated degradation. Hence, cinnamon polyphenols and their metabolites probably work as mediators in gene regulation and receptor/pathway activation, leading to an adaptive response against renewed insults.

Inflammatory bowel disease (IBD) incidence has increased in the last decades due to changes in dietary habits. IBDs are characterized by intestinal epithelial barrier disruption, increased inflammatory mediator production and excessive tissue injury. Since the current treatments are not sufficient to achieve and maintain remission, complementary and alternative medicine (CAM) becomes a primary practice as a co-adjuvant for the therapy. Thus, the intake of functional food enriched in vegetal extracts represents a promising nutritional strategy. This study evaluates the anti-inflammatory effects of artichoke, caihua and fenugreek vegetal extract original blend (ACFB) in an in vitro model of gut barrier mimicking the early acute phases of the disease. Caco2 cells cultured on transwell supports were treated with digested ACFB before exposure to pro-inflammatory cytokines. The pre-treatment counteracts the increase in barrier permeability induced by the inflammatory stimulus, as demonstrated by the evaluation of TEER and CLDN-2 parameters. In parallel, ACFB reduces p65NF-κB pro-inflammatory pathway activation that results in the decrement of COX-2 expression as PGE2 and IL-8 secretion. ACFB properties might be due to the synergistic effects of different flavonoids, indicating it as a valid candidate for new formulation in the prevention/mitigation of non-communicable diseases.

Poor eating habits have been correlated with an increased probability of developing chronic health problems, including weight gain. In particular, dietary choices during the first years of life can have a lasting impact on dietary preferences and habits. Parents strongly influence the child’s relationship with food which will be maintained for the rest of their life; in particular, a greater sense of maternal self-efficacy is correlated with healthier eating habits and the child being less overweight. To date, there are few studies investigating the relationship between parental eating habits, self-efficacy in promoting healthy behaviors and the use of social media (SM). The general purpose of our study is to investigate the eating habits of families, food awareness and choices and the use of SM to search for pediatric nutrition content. The habits were collected through a questionnaire administered online on the most popular SM platforms. Data show that parents take care of their children’s food choices (96.1%) and rarely comply with their requests (77.9%). More than half read product labels (56.1%) and the origin (43.9%) before purchasing. Overall, 44.1% are influenced by TV and newspapers regarding their purchases, while 39.4% are influenced by the opinions of their friends and relatives. Food style correlates positively with the influence of TV and newspapers (r = 0.238) and the influence of friends and relatives (r = 0.231). Overall, 77.1% aim to follow a healthy diet, even if fish (24.5%) and vegetables (36.3%) are difficult to include in the child’s diet. Instagram (50.2%) and Facebook (36.3%) are the SM platforms most used to search for information on pediatric nutrition. Health professionals’ (60.3%) and institutions’ (24.9%) profiles are the most followed for reading articles and blogs (59.4%), but without direct interactions (78.9%). Only 20% are satisfied with the content found. Parental self-efficacy in promoting a healthy diet for their children correlates positively and moderately with encouragement to follow a healthy diet (r = 0.340) and control over the amount of snacks and sweets consumed (r = 0.302). The data demonstrate parents’ interest in using SM to search for information on pediatric nutrition but indicates that few (33.3%) are satisfied with what they find online. Therefore, future educational interventions need to be refined to help parents to better influence children’s eating habits.