This study determines the sensitivity and specificity of a screening test to detect perceptual abnormalities and whether there are differences between gender. Vision is a complex process involving visual perception. Any alterations can affect learning, so having a screening test in Spanish that is easy to use and reliable for timely diagnosis will reduce the percentage of visuo-perceptual interference during learning process. A total of 200 subjects participated, aged between 8 and 15 years old, with good visual acuity, and no strabismus, amblyopia, ocular pathology, or neurological damage. The Petrosyan questionnaire (screening test) was employed to identify symptoms associated with perceptual impairment, and a subsequent assessment was conducted to evaluate perceptual abilities. The mean age was 11.5 years (57% male; 44% female). The screening test indicated that 30% of the subjects were suspected of having perceptual alteration, while 24% were diagnosed with a real alteration in perceptual abilities. The sensitivity was 1 and the specificity was 0.92. The Spanish version of the Petrosyan questionnaire has high sensitivity and specificity values and is therefore considered very accurate for identifying the need for a perceptual assessment. There are statistically significant differences in perceptual abilities according to gender. The female group shows more symptomatology and a higher percentage of alteration in perceptual skills.

El trastorno del espectro autista (TEA) se caracteriza por una alteración generalizada del desarrollo cerebral, que afecta la socialización, comunicación, imaginación y reciprocidad emocional y se evidencia mediante conductas repetitivas e inusuales. El uso de prismas gemelos estimula una reorganización neurológica y provoca cambios en la percepción visual. El objetivo del presente artículo fue evaluar las habilidades visuales y determinar el efecto de los prismas gemelos en la atención, postura y comportamiento de los niños con TEA. Se elaboró un estudio de intervención con muestras pareadas antes-después; se incluyeron 20 niños con diagnóstico de TEA en edades de 4 a 16 años, y se realizó una evaluación optométrica basal, aplicando un cuestionario para identificar síntomas y otra posterior al uso de un anteojo con prismas base superior, durante 4 meses. El análisis estadístico se realizó con prueba t de Student para muestras no independientes. Se halló que la media de edad fue de 10,05 años, 90 % sexo masculino, 45 % hipermetropía, 30 % insuficiencia de convergencia, 90 % fusión y 85 % estereopsis gruesa. El promedio de aciertos en el cuestionario inicial fue de 18,50 ± 7,64 y en el final de 13,20 ± 7,53 p = 0,000. Finalmente, se concluye que la hipermetropía se presenta en el 45 % de los casos; un 30 % presenta insuficiencia de convergencia, y el 85 %, estereopsis gruesa; asimismo, el uso de prismas gemelos de 3 dioptrías base superior produce cambios estadísticamente significativos en la postura, atención y comportamiento, por lo que se propone como alternativa de manejo adicional en niños con TEA

Diabetic retinopathy (DR), recognized as a progressive neurovascular and microvascular complication of diabetes, remains one of the leading causes of visual disability worldwide, within the context of a sustained increase in ophthalmic diseases and retinal vascular disorders that compromise vision. This study aimed to characterize the progression of diabetic retinopathy in a streptozotocin (STZ)-induced Wistar rat model. A single dose of 65 mg/kg body weight was administered, with follow-up periods at 2, 4, 8, and 10 weeks, compared to healthy controls. STZ-induced rats exhibited reduced weight gain compared to the control group. They also showed markedly variable hyperglycemia, with glucose concentrations ranging from 250 to 530 mg/dL. Histological analysis of retinal tissue at week 4 revealed early signs of vascular compromise, including early indications of a microenvironment conducive to neovascularization and edema. By week 8, retinal damage had progressed to hemorrhage, persistent edema, and layer-specific vascular disruption. At week 10, intensified neovascularization and exacerbated edema indicated advanced microvascular deterioration. Immunofluorescence analysis demonstrated a temporal accumulation of CD8⁺ T cells in the retina, correlating with photoreceptor degeneration. The coordinated dynamics of CD4⁺ and CD8⁺ T cells suggested transient immune activation during STZ-induced retinal degeneration. Gene expression profiling revealed a proinflammatory and pro-oxidative retinal microenvironment, characterized by the overexpression of angiogenic pathways and proliferative signals. Simultaneously, the antioxidant response appeared partially impaired. Collectively, these findings provide mechanistic perspective on the multifactorial nature of diabetic retinopathy. Oxidative stress, inflammation, and angiogenesis converge to disrupt retinal homeostasis. This experimental model may serve as a reliable platform for future studies aimed at elucidating disease pathophysiology, identifying novel therapeutic targets, and evaluating emerging ophthalmic antidiabetic interventions.

Age-related macular degeneration (AMD) is the leading cause of blindness. Although its development is poorly understood., high concentrations of reactive oxygen species, maybe trigger it. The aim of this study was to analyze whether the antioxidant action of the dietary supplement Ginkgo biloba (EGb-761) can reduce the progression of AMD. A clinical trial was conducted in Mexico, with people over 55 years of age. AMD patients were treated with EGb-761: 50 mg/day (n = 26) or 100 mg/day (n = 22) for 3 months. A control group with 22 healthy people (without treatment) was included. Before and after treatment, functional and structural ocular tests were performed, and systemic oxidative stress (OS) was measured.Changes between baseline and after the treatment with both doses were significant (P < 0.05). Contrast sensitivity increased 16% and 17%, the number of metamorphopsias (central vision integrity) decreased 100% and 95%; central perimetry (scotoma) decreased 93% and 88%, and hyperpigmentation (autofluorescence) decreased 88% and 89%, respectively. For OS, malondialdehyde concentration decreased 7.6% and 8.5%, and reduced glutathione levels increased 5.3% and 7.1%, respectively. We suggest giving low doses of Gb to older adults with early-stage AMD educe or avoid side effects.

Several chronic inflammatory processes are currently being studied in relation to other systems to better understand the regulation mechanisms and identify potential therapeutic targets. A significant body of evidence supports the role of the nervous system in regulating various immunological processes. This study investigates the relationship between pterygia and the sympathetic nervous system, focusing on their interaction in the inflammatory response and fibrogenic process. Sixteen surgical specimens of primary pterygia and four conjunctival tissue samples were examined, and their morphology was analyzed using hematoxylin–eosin and Masson’s trichrome stains. The gene expression of adrenergic receptors, as well as inflammatory and fibrogenic cytokines, was also assessed. Additionally, both adrenergic receptors and tyrosine hydroxylase were found to be localized within the tissues according to immunohistochemistry and immunofluorescence techniques. Increased expression of proinflammatory, fibrogenic, and adrenergic genes was observed in the pterygium compared to the healthy conjunctiva. Adrenergic receptors and tyrosine hydroxylase were localized in the basal region of the epithelium and within blood vessels, closely associated with immune cells. Neuroimmunomodulation plays a key role in the pathogenesis of pterygia by activating the sympathetic nervous system. At the intravascular level, norepinephrine promotes the migration of immune cells, thereby sustaining inflammation. Additionally, sympathetic nerve fibers located at the subepithelial level contribute to epithelial growth and the fibrosis associated with pterygia.

La producción excesiva de secreción mucoide y los cuadros infecciosos son una queja frecuente en los pacientes que usan prótesis oculares como consecuencia de la pérdida del globo ocular. El propósito de este trabajo es identificar microorganismos presentes en las cavidades anoftálmicas de portadores de prótesis oftálmicas. Se obtuvieron muestras de secreción ocular de 17 hombres y 5 mujeres entre los 13 y los 80 años de edad para realizar un cultivo microbiológico y determinar la presencia y diversidad de bacterias. La identificación de género y especie se realizó con el sistema automatizado VITEK2. Después del período de incubación, 60% de las muestras presentaron resultado positivo para presencia de bacterias, siendo el Staphylococcus epidermidis (26.67 %) la más frecuente. La mayor proporción de resultados positivos se encontró en pacientes con prótesis oculares en mal estado o con más de 7 años de uso.